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Volume 13, Issue 6
Displaying 1-12 of 12 articles from this issue
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(1) Additional Opinion an Measurement of serum Total CholesterolYoshito TANAKA1959 Volume 13 Issue 6 Pages 425-430
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSThe absolute value of serum total cholesterol level always comes into question at the clinical study of hypertension. The author measured it by Broor's method under somevariable. From the results obtained, the following conclusions were reached.
1) Variation of coloring due to room-temperature and time.
The reaction of Lieberman-Buchard indicates that the time, in which it reaches to the highest coloring, is variable. The extent of light-absorbtion stabilizes for several minutes at the time of its highest coloring. This point is lower in summer and rather higher in winter.
2) Observational error.
The observational error on the 25 patient's investigation was measured as of 4.52% at maximum, 0% minimum and 2.14% on the average.
3) The recovery test.
The recovery test showed the high reliability of the method.View full abstractDownload PDF (1091K) -
Yoshinabu KISHIGAMI1959 Volume 13 Issue 6 Pages 431-443
Published: 1959
Released on J-STAGE: December 02, 2011
JOURNAL FREE ACCESSRadioactive isotope treatment for malignant neoplasmas has been achieving a remarkable progress, particularly in it's internal use. Radioactive phosphor (Cr32PO4) was used for a time, then radioactive colloidal gold (Au198) took it's place.
Treatment of pleuritis and peritonitis carcinomatosa with the radioactive colloidal gold shows satisfactory result. Since September 1955 the author utilized gold manufactured by the Radio-Chemical Center, England.
Mice with ascites tumor (Ehrlich) were tested with this. Change of tumor cells, pathological reaction of cancer cells and survival period of the diseased animals were tested and these indicated fairly satisfactory therapeutic effect with less secondary reaction than Cr32PO4.
Then Au198 was applied clinically to human bodies resulting in far superior effect to the radioactive phosphor (Cr32PO4).
85 patients with malignant neoplasma were observed in a few months; intra peritoneal injection-43 cases, intra pleural injection-19 cases and other procedure-23 cases.
1) At the 7th days diiferent doses of Au198 were intraperitoneally injected to mice with ascites tumor. Injection of 1mc manifested the most prominent result.
Described formula indicates absorbed and effective roentgen dose (rad). Assuming volume of ascites of a mouse as of 10cc, the rad will be 100μc/g/tissue.
2) Ascites dropsy of the mouse was stopped by giving injection only once ; simultaneously, prolonged survival effect was cinsiderable.
3) Several injections a month apart is considered adequate.
4) 62 cases were injected intra pleuro-peritoneousily. 19 cases out of 62 lived more than 6 months while 11 cases survived more than a year.
5) One necessary therapeutic dose is 30 to 100mc, Over dosage radiation should be strictly avoided since it causes peritoneal effusions resulting in ileus. Maximum dosage is estimated as 80mc.
6) Au198 brings humans a ray of hope recovery from carcinomatous pleuro-peritonitis. A complete cure is expectative, if Au198 is applied at the early stage before the malignant tumor cells form a big tumor. The longest clinical arrest I have experienced was 3 years and 2 months.View full abstractDownload PDF (12315K) -
Hajime TOMINAGA, Masuo MAEKAWA, Eiichi MATSUOKA, Shoichi SEINO, Mitsua ...1959 Volume 13 Issue 6 Pages 444-452
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSAfter being taken with palpitation and then grand mal seizure at the age of 37 this patient had complained of myoclonic twitching of his whole body until his death of at the age of 60 and 8 months and had suffered from motor paralysis of the left side of the body at the age of 57 and 59.
In 4 of the patients children, the same myoclonic twitching has been found. An autopsy of this case showed encephalomalacies and / or hemorrhagic softenings of the claustrum and the lateral part of the putamen of both cerebral hemisphere, the subcortical white matter of the lobules parentralis, prouneus and cuneus of the right hemisphere and the right medial lemniscus. The symptoms of this case are attributed not to degenerative as in so-called myoclonus epilepsy, but to focal vascular lesions, following those many old and new hemorrhages.View full abstractDownload PDF (7772K) -
Masakazu SEINO, Motoo ISHIDA, Toshiro MACHIMURA, Makoto KOJIMA, Masuo ...1959 Volume 13 Issue 6 Pages 453-458
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSA male patient, 34 years of age, who had suffered from protean signs of both nervous and psychic disease, has been treated for 5 years in our clinic.
Asthenopia by neutritis retrobulbaris, marionnettegait, scanning speach, tremor of hands and head, spastic signs of tendon reflexes and horizontal nystagmus were exacerbated mostly once a year with changes of his personality such as emotional-instability, selfishenss, moodiness, anger and wasting money.
The constellation of these signs suggests a group of multiple lesions in central nervous system. On the other hand, tendency to reminion was noted several times in past 10 years of his history.
While multiple sclerosis in Japan is regarded as extremely rare, we previously reported one case with multiple sclerosis syndrome and in it, diagnostic criteria and behaviour and personality disorders. Head trauma as a promoting cause was discussed.View full abstractDownload PDF (4038K) -
(1) States of Wounds and SymptomsTaro TOYOIZUMI1959 Volume 13 Issue 6 Pages 459-463
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSThis clinical study concerns forty-three cases of brain injury (acquired in the world war 1937-1945) in which the causative alien substances remain. The alien substances were in some cases shell or bullet fragments and in other cases bone fragments. These cases have been followed for ten to twenty years.
11) The alien substances are in the frontal lobe in 7 cases, parietal lobe 14 cases, tempora obe 8 cases, occipital lobe in 4 cases, and in the brain stem in 10 cases.
The site of lodgment did not always correspond to the area of entry.
2) In 45.5% of the cases the wounds were from splinters of bullet or shell, 27% were blind bullet wounds, 14% were piercing bullet wounds.
3) Residual clinical symptoms were: hemiplegia 63%, disturbance of sensation 49%, aphasic 35%, defect of visual field 22%, disturbance of deep sensation 14%, ataxia 14%, amblyopia 5%.View full abstractDownload PDF (1008K) -
Atsutaka UEHARA, Teru ONOGUCHI, Sentaro AKIYAMA, Seiji SUZUKI, Kikuo U ...1959 Volume 13 Issue 6 Pages 464-467
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSFelix reported that brain supplies the liver with important intermediate products of metabolism and choline is the possibly the one.
It is also true that choline has a lipotropic action on the fatty liver and this action of choline depends on the function of the adrenal gland.
Experimental studies were made on the both normal and tuberculous mice and we obtained following results:
1) We recognized increase of both liver fatty acids and brain cholinesterase activity when cortisone was injected to the normal mouse.
2) With injection of small dosis of cortisone (0.02mg per day), fatty acids of tuberculous mice did not increase in the liver, while activity of cholinesterase rose two fold in the normal animals.
3) Following injection of C-C14 in the tuberculous mice, neither increase of fatty acids nor increase of cholinesterase activity were noticed.
From these results we conclude that in the tuberculous mouse the activity of brain cholinesterase increases, but choline is unable to reveal its lipotropic action. When a small dose of cortisone is injected into the tuberculous mouse esterase activity increases and the fatty acids in the liver decreases.View full abstractDownload PDF (716K) -
Uruo NISHIKAZE, Toru KUBO, Minoru KOBAYASHI, Ayako ASHIHARA, Takao ASA ...1959 Volume 13 Issue 6 Pages 468-471
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSFor the purpose of clarifying the mechanism of development of anemia in tuberculosis, one of the authors (Nishikaze) reported that in experimental tuberculosis the primary anemia appearing in the early stage and the secondary anemia in the later stage can be distinguished by the accelerated red cell destruction with the increased bone marrow activity in the former and the depression of the hematopoiesis with the lowered function of reticuloendothelial system in the latter.
In this paper the author reports the results obtained by observing the reticulocyte index (RCI) in tuberculous patients. The RCI proposed by Seno et al., is derived from the following foumula:
RCI=Nt'/Nt, Nt'=a(b-c)/1, 000t=1, 618 in the male and 1, 451 in the female in mean value. Where Nt'=the RC number liberated from bone marrow into 1cu. mm. of blood, b=RC numbre in 1, 000red cells, c=old RC in 1, 000red cells obtained from the RC number remainingg after the complete maturation of RC in vitro, t=ripening of young RC by hour, Nt=the mean value of Nt's found in normal organism. This RCI gives a good indication of the grade of bone marrow activity, 1 in the normal individual, greater than 1 in activatad hematopoiesis and less than 1 with lowered activity. All the tuberculous patients tested have given the values less than 1, indicating lowered activity of bone marrow.View full abstractDownload PDF (814K) -
Kyotsuu ITAKURA1959 Volume 13 Issue 6 Pages 472-477
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSThe author studied the effect of combinations of SI, DBS and antituberculous drugs such as SM and HNH on “Myco. tuberculosis” var, hominis H37Rv and Akabatake-strain which were highly resistant to PAS, SM and INH. The result was summarized as follows.
1) DBS and SI have been found to be markedly bacteriastatic and bacteriacidal in vitro on “Myco. tuberculosis” H37Rv and Akabatake-strain.
2) A synergystic action between DBS and INH against Myco. tuberculosis H37Rv has been found, while the action was not observed in combination of SM, INH and DBS against “Myco. tuberculosis” Akabatake-strain.
3) The combined action of SM, INH and SI in preventing or delaying the emergence of resistance was significant while DBS was slightly effective on SM.View full abstractDownload PDF (1153K) -
(A Statistical Review of Double Primary Carcinomas and Carcinoma of the Male Breast)Tasuku YAMADA, Itsutoshi FUKUSHI, Toshio HARAIKAWA1959 Volume 13 Issue 6 Pages 478-486
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSA 61-year-old man came to the hospital with the chief complaint of an inflation-like discomfort in the epigastrium and a mass in the left breast. An operation on the patient with gastrectomy and simple mastectomy resulted in a histological finding of double primary carcinomas.
The tumor of the left breast was a cylindrical epithelial cancer while one of the greater curvature of pylorus was a combination of mucous and cuboid epithelial cancers.
The year 1957 found reports of double primary carcinomas in Japan affecting 55 patients including the one recorded here. Fifty three per cent of the known patients had the disease accompanying gastric cancer. But a combination of gastric cancer with that of the breast was present only in three instances. Except for the individual recorded here, there have been no male patients in whom cancers developed concurrently in the stomach and the breast. Of these patients none had gastric cancer.
In 1957 reports of male patients with carcinoma of the breast in Japan with the addition of the one recorded here totaled 66. It is difficult to draw a conclusion as to whether trauma or hormonal imbalance accounts for the incidence of carcinoma of the breast in man. Neverthless, there is good evidence to show that the latter plays a larger part in etiology than would otherwise be thought. Trauma and chronic irritation are considered to combine with this, doing much as an indirect cancer-inducing factor. Male patients represent 1-1.5% of the total cases with carcinoma of the breast and the rate, both Japanese and foreign, is practically equal. However, particular attention should be given to the breast cancer in man as it becomes metastic at an earlier time than at which this occurs in womn.View full abstractDownload PDF (5413K) -
Harusue TSUJIKAWA, Saburo NAKAMURA, Yasushi IIZCTKA, Shoji YOKOYAMA, K ...1959 Volume 13 Issue 6 Pages 487-491
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDownload PDF (4358K) -
Yoshiyuki MIYABAYASHI, Hirashi KOIZUMI, Shigeru OGAWA1959 Volume 13 Issue 6 Pages 492-493
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDownload PDF (328K) -
Kazuo NAGAKAWA, Saburo SAHO, Yoshikazu YOSHIDA, Rokuro SAITO1959 Volume 13 Issue 6 Pages 494-496
Published: 1959
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDownload PDF (3895K)
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