Mucosal pattern in 79 cases of chronic gastritis were classified by the findings of gastrocamera into three types; and the each type were in mild, moderate and severe.
Difference in difficulty to get good gastrocamera pictures existed in regard to various gastric areas and the types of mucosal pattern. So, in evaluating the gastrocamera findings various conditions, such as distance from lens to mucous membrane, must be considered.

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Thirty one cases of biopsy were performed and the results obtained are as follows.
1) The succeeded percentage were 95% in liver, 30% in kidney and 100% in spleen.
2) As the by-effects, in liver biopsy cases abdominal pain was complained in 50 per cent, in kidney biopsy cases light microscopic hematuria and lumber pain were observed.
3) In the homogenous pathological changes of liver (liver cirrhosis, acute hepatitis, serum hepatitis etc.), the percentage of diagnostic accuracy is very high, but in the solitary changes (for instance liver cancer) is very low.
4) In comparison with the bioscopic and operative diagnosis it could be confirmed.
5) The another applied aspect of the biopsy is the so-called necropsy, which is carried on instead of autopsy.
6) When the indication is strict, the preparations are complete and the diagnostic decision is cautious, the biopsy is a very safe useful diagnostic method.

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Several papers of the cholesterol-lowering agents have been reported, but at this time the author want to report the comparison of the effect of many kind of the drugs.
1) For the cases which titer of serum total cholesterol showed below 250mg dl, Triparanol is more effective at early stage, but the Cholagogne and the organic iodinepreparation (Jolethin) are effective too.
2) For the cases which titer of serum total cholesterol were below 300mg, dl, Triparanol and Jolethin had good effect.
3) For the cases which titer of serum cholesterol were over 300mg dl, Jolethin, Cholagogne, Glycyron and Triparanol had the good effect.
4) Except these drugs, Panthotenic acid and thioctic acid have a poor effect of cholesterol-lowering, but they are useful to prevent the development of arteriosclerosis and are effective for cholesterol-lowering combined with the other drugs.
5) The aim of therapy of the arteriosclerosis must be not only cholesterol-lowering, but control or prevention of arteriosclerosis. Sometimes in the arteriosclerotic patients hypothyroidism in seen, so the organic iodine preparation, effective for cholesterol-lowering, is to use at many arteriosclerotic patients.

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The use of the reprocessed Ogawa media were studied from medical and economical points of view.
The results were as follows.
1) Medium:
New media was routine 3% Ogawa's.
Each of reprocessed media was selected from the post-usage ones, which had no discolorations, degenerations, and desiccations after culture with negative result, and which was supplemented with 2ml. of its origin.
2) Culture:
A series of 209 cases, divided into continuous and intermittent culture positive group were cultured in both new and reprocessed media at the same as routine methods, and were examined after 4, 6 and 8 weeks' incubation.
3) Cultural Growth:
No significant difference in these two media were shown.
4) Economical Data:
During whole one year of 1961 in the 2nd Hokkaido National Sanatorium, we couldrelease a total money of 54, 549 yen and 80 mens of medical technicians, by using those reprocessed media. So, it was possible to convert these saving money into the other laboratory fields.

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A case of spontaneous subarachnoid hemorrhage presenting abnormal electrocardiogram could be summed up in the following details.
Three days after the hemorrhage the tracing of the electrocardiogram consists of prolongation QT interval, wide giant upright T waves and prominent U waves.
But 7 days after the hemorrhage, instead of these findings, there are abnormal Q spikes and elevation of ST-T segments in Lead II, III and aV_F just like posterior myocardial infarction.
After that these infarction-like-findings gradually diminished. On the 18th day disturbance of atrioventricular conduction are present, but 1 and 1/2 month after the hemorrhage these alterations cannot be observed.
There are no special electrolyte changes, and no clinical and no other laboratory findings indicating coronary artery disease.
After the report of Levine in 1953; Burch, Wasserman, Ozawa, Takahashi, Fentz and some others reported the same changes in patients with cerebral vascular accidents and tumors of the central nervous system, and in patients operated on the basic area of the brain.
There are some experiments to investigate these phenomenon. In 1958 Roganti observed the changes of T waves and the prolongation of QT interval, when he injected some inactive liquid into the spinal cavity of animals. It showed that elevation of cerebrospinal pressure may be one of the factors in electrocardiographic abnormalities.
Recently it was discussed that there was an integrating center of the cardiac function in the central nervous system. Levine, Pool and Takeuchi thought it was orbital surface of anterior lobe and Fentz concentrated on area 13 (orbital surface of anterior lobe) and area 24. Cropp and Manning explained that these areas were cortical representation of vagus. These belong to limbic system.
These findings were observed not only in cerebrovascular accidents but by trauma and tumor. We believe electrocardiogram should be utilized even for deciding diagnosis and prognosis of cerebral disorders.
But the mechanisms of these abnormalities are still in early stage of the research at present and it will be found a big key-point for clearing up the cortical localization of all visceral function, when a better and more dependable mechanism is realized.

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In spite of various observations on the subject it seems that any conclusive theory has not been established as yet regarding how the tuberculous hypersensitivity is related to the process of tuberculous diseases and what the significance of it is to the specific resistance of human body against tuberculosis.
In order to elucidate this problem we have taken up the skin hypersensitivity to tuberculin which is generally employed in practice and studied how it changes in accordance with the process of tuberculous diseases.
We picked up one hundred in-patients of our sanatorium who had tuberculous lesions in the osteo-articular system. We have inoculated 0.1ml of 2, 000×Old Tuberculin intracutaneously on the flexor surface of both forearms once a month, left and right alternately, for four and a half years. We measured both the vertical and horizontal diameters of the erythematous infiltration forty eight hours after the injection and took the mean of the two diameters. We have classified the results of the test in three grades according to the variation of the diameters of the reddening produced by tuberculin test : when the reddening is 3mm or more bigger in diameter than the original one we classified it as “intensified”, when the extension or the contraction is within 3mm as “stationary” and in case the reddening contracts beyond 3mm as “reduced”.
We have checked on our patients during the whole course of this study the accelerated or the retarded reactions at the site of repeated inoculations of tuberculin which are deemed of significance by most clinicians in the mass physical check-up, but from our experiment we are inclined to feel that we might be justified if we paid little heed to these phenomena in this report.
The summary of the results of our experiment is as follows:
1) Of the fifty five cases of clinical improvement, twenty nine were “intensified” and eleven “reduced”. Of the thirty nine cases which showed no clinical improvement, ten were “intensified” and seventeen “reduced”.
We have found an inductive-statistically significant difference between the two groups.
2) In the abscess forming cases, when the diameters of the infiltration were compared six months before and after the formation of the abscesses, the “reduced” reactions' were predominant and in the group in which the abscess, though still existing, became gradually smaller we found more “intensified” reactions.
3) In the cases in which the fistulae exist the “reduced” reactions are prevailing.
4) In the cases that had been treated with chemotherapeutics, when the diameters taken six months before the commencememt of the therapy are compared with those taken six months after the treatment, it appears those that showed weak reactions earlier became “intensified” later and vice versa.
5) Studying the results of the test on the surgically treated cases which were classified into two groups, one those directly operated and the other conservatively treated, we found the former showed more tendency than the latter to the “reduced” reactions in comparison of the mean of the diameters six months before and after the operations and in the latter the majority was the “stationary”.
6) The variation of the results of the tests on those sixteen cases that showed exacervation or developed complications in the tuberculous lesions either in the joints and bones or in the lungs, comparing them six months before and after the developments of the exacervation or the complications, indicates the “intensified” reaction in three tall these three being improved), the “stationary” in five (four improved and one dying) and the “reduced” in eight (four improved, two not improved and two dying).
7) We have practiced tuberculin test on the patients once

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