Spectrophotometic examination has been conducted on the mechanism of clinical reaction of psychotropic drugs on Pyridoxal phosphate; activation type of Vitamin Bs group.
The absorption spectra has been measured on the drugs in the reaction solution; M 15 phosphate buffer, pH 7.0, which were added Pyridoxal phosphate. Phenothiazine derivates (Chlorpromazine, Levomepromazine, Perphenazine), Megimide and Isonicotinic acid hydrazide indicate removal of maximum absorption of Pyridoxal phosphate (390mμ) to a shorter wave length but these changes were not noticeable in Reserpine and Phenobarbital.
These results suggest to us that there should be a chemical combination between the drugs and Pyridoxal phosphate.

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Upon completing the diagnosis and treatment, using various kind of filters, measurement, meaurement of thyroid uptake rate on the patients was performed.
The transmission rate of each filter is as the following; A filter 26%, B filter 10% and AB filter 3%.
Results:
1) In regard to the thyroid uptake rate, at the effective distance 30cm, the AB type was the largest, then the B type, the A type and the O type follows respectively.
2) At the effective distance 50cm-A≅AB O≅B
3) It is advisable to apply B type to eliminate unfavorable influence of the body back grounds.
4) When the room back grounds are high, then the AB type will indicate the correct value.

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Changes in arterial blood caused by the impairment of intrapulmonary gas exchange results in a disturbance in arterial acid base balance.
Disturbance in tissue metabolism can vice versa, produce the same result in the arterial blood, especially when the control on the venous A-B balance by the lung is impaired, On such a basic concept in general relationship among pulmonary function, A-B balance and tissue metabolism, a trial was made to see the influence of pulmonary dysfunction on tissue metabolism by the analysis of arterial A-B balance.
Result:
Patients with pulmonary tuberculosis were classified into 3 groups according by the N. T. A. classification.
1) Observation at Rest
a) SaO₂-in moderate and far advanced groups, SaO₂ below 92% was observed in considerable number of cases and the lowest SaO₂ below 82% in one case of the far advanced group. Hematocrit in exceptional cases showing high SaO₂ was remarkably small, which showed these cases suffering from anoxia.
b) PaO₂ and CaCO₂-in proportion to the severity of the diseases, increases in both of PaCO₂ and CaCO₂ became remarkablee.
c) pH (a) -decrease in pH (a) follow the increase in both PaCO₂ and CaCO₂.
d) (B_B) b-arterial (B_B) b did not always increase in proportion to the increase in CaCO₂, which was supposed in suggest that in some cases there might be trespassing of tissue, i. e., lactic acid, on the arterial blood components even at rest and that (B_B)b usually increased with the appearance of respiratory acidosis might mask such a process.
Arterial lactic acid in these patients stayed at the highest level of the normal range.
According to these results, it is concludedt hat the patients with pulmonary tuberculosis are apt to suffer both from asphyxia with respiratory acidosis and from tissue anoxia in their advanced stages.
2) Observations on Exercise Test
Patients with asphxia were put to the bicycle exercise test for ten minutes, After the bicycle test, the patients showed a decrease in SaO₂, pH (a) and (B_B)b, and an increase in arterial lactic acid and PaCO₂, which indicated they fell into mixed form of acidosis respiratory and metabolic, The absolute values of these indicates that arterial blood in these patients can easily be affected by the trespassing of the tissue acid and that over producted CO₂ can not easily be blown out of the lung.
Careful analysis of the arterial A-B balance at rest and after exercise can reveal the effect of the anoxemia on the tissue metabolism.
By putting resistance at the site of the mouth piece in bronchospirometry, information was obtained that a decrease in so called “calibre bronchique” (Tiffnean) could be acause of the impairement of intrapulmonary gas exchange.

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The relationship between lymphdynamics and pulmonary edema were observed and the results obtained were as follows:
1) In the subject with pulmonary edema, the increased flow of lung lymph, the decrease of protein in the lymph and the hemorrhagic lymph were especially remarkable. In the subject without pulmonary edema, the flow of lymph returned to its normal condition at the time of slaughter.
2) The condition of pulmonary edema was not always coincidental, with the increasing rate of flow of lung lymph.
3) There were many cases in which the flow of lung lymph and the pulmonary arterial blood pressure had generally the same transition.
4) It was not observed that obstruction of the lung lymph tends to stimulate the production of pulmonary edema.
5) It is significant and valuable that the pulmonary hemodynamics takes part in the production of postoperative aute pulmonary edema. On the other hand, the pulmonary lymph dynamics concerning the reabsorption of transsudate is not significant.

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A streptomycin-dependent strain of a Mycobacterium “Jucho” can synthesize the ribonucleic acid (RNA) in the absence of streptomycin and can reach the lag phase. However, it cannot reach the logarithmic growth phase.
Incorporation of P³²-phosphate into the deoxyribonucleic acid (DNA) fraction of the organism is markedly inhibited in the absence of streptomycin, while incorporation of p³² into the other fractions (acid-soluble, phosphatide, RNA and protein) but are not inhibited in the absence of the drug.
The streptomycin-dependent strain can synthesize RNA and protein, however, it cannot synthesize DNA in the absence of streptomycin.

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Of the outpatients at the dermatological clinics in the two years from 1958 (the first year) through 1959 (the second year), this joint study unit made a statistical investigation of patients with epidermal disturbances due to external remedies (patent medicine), cosmetics on the market and occupational epidermal disturbances. Twenty national hospitals took part in this investigation in the first year and fifteen in the second year.
1) The numbers of cases of dermal disturbances due to external remedies were 371 in the first year and 348 in the second year, And in the majority of cases the symptom was dermatitis, however, in the second year statistic showed 11 cases with pigmentation.
2) Cases ascribed to cosmetics were 236 in the first year and 189 in the second year. Regarding symptoms other than dermatitis there were pigmentation, leukomelanodermia alopecia and acne and the numbers or such cases were 18 in the first year, however the number reduced to 8 in the second year.

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We investigated the late results of 359 pulmonary tuberculosis patients who at the time of admission were found to have cavitation and then after discharge within 5 years showed progression. These patients belonged one of the following y groups respectively.
I Group 68 open negative syndrome (ONS)
II Group 106 resection or plasty of ONS
III Group 62 open negative
IV Group 65 filled in cavity
V Group 57 linear changed cavity
Relapse rate: I group 11.8%, II group 4.7%, III group 51.6%, IV group 21.2%, V group 5.2%. Result
As to the relation between the relapse and the clinical findings of the I group, we found that the following factors played a big role in the high relapse rate; a)male, b)thirty years of age, c)delay of admission, d)less than one year chemotherapy at the sanatorium, e) within six months from the time of ONS till discharge, f) before discharge the period of sputum negative-less than one year, g) multiple cavities, or cavities in the infiltration at the time of discharge, h) less than one year stay in the sanatorium, i) no chemotherapy after discharge. The cases of relapse increased in parallel with the time process after discharge.
In a few cases we found changes of the roentgenogram and conversion of sputum to positive. Patients of J group voluntarily reported sputum tests resulting 10% positive After discharge 90% of I group was administered chemotherapy. And 60% had employment, however 16% of them lost jobs by reason of unsatisfactory health.
It seemed that most of patients who, at the time of admission, were accompanied with following factors could take process of ONS; they are : old-aged, admission delayed, long term chemotherapy before admission, fibracaseous tuberculosis or widely extended lesions, indurative cavities and paperlike thin wall cavities.
But a large number or similar case was not seen in the patients who used INH.

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