The following results were obtained in the statistical survey of acute appendicitis of infants and children (under 13 years old) during the 8-year period, 1951 to 1958, at the 2nd Tokyo National Hospital.
During the same period there were 5, 750 operations for appendicitis all age groups in the same hospital and those of infants and children were 642 cases (11.2%).
1) Age & sex: As the older the age, the more the number of cases increased, counting 313 cases of males and 329 cases of females.
2) Season & month: The most large number of cases were operated in spring, then comes in summer time. In May the most, and in July, April and August followed.
3) Symptoms & signs: On the first physical examination, patients showed almost the same symptoms and signs as the adults, complaining of pain in epigastrium accompaning by the other symptoms; nausea and vomiting, more often diarrhea was complained than constipation.
4) Leucocytosis & fever: The number of leucocytes and the rise of body temperature were not always parallel to the state of the patients, for instance we have experienced many cases of perforation (11.7%) even when the number of leuicocytes were under 10, 000, and in 16% the body temperature were under 37°C.
5) Perforation: The perforated cases were 17.5%, and the percentage of the panperitonitis were more common compared with the adults cases.
6) Mortality: During our series of acute appendicitis of infants and children no mortality was experienced.

View full abstract

A brief review of the Z-test was given. The Z-test, devised by Ino, is a new method of caloric testing which can measure the renal latent time indicative of excitement in the labyrinth. By this test we can distinguish between central and peripheral diseases.
The author carried out this test on normal subjects and determined the normal value of this test, and then observed the results of testing 30 cases of Ménière's disease, 30 cases of atypical Ménière's disease and 12 cases of brain tumor.
For purposes of investigating the value of this test, the author carried out the experiments with rabbits, which was consisted of injury of cerebrum, cerebellum and labyrinth, experimental hydrops of labyrinthi, experimental D. P. due to the destruction of utriculus and sacculus.
The author studied comparatively this test before and after the injury of these vestibular apparatus. These experiments showed that the localization of vestibular lesions are more easily diagnosed by this test.
The direction of D. P. can be determined by the results of Z-test of both ears. The author made clear that a deep relationship was observed between D. P. and the results of Z-test.
In conclusion this test contributes much to local diagnosis of the diseased vestibular region.

View full abstract

Previously the author reported the Ultramicro-I₂-Hydrazine-Azotometry (AZM). In this report applying this method the author describes the ultramicro determination of I-, oxalic acid and Ca⁺⁺.
1) Ultramicro Determination of I-
Following the procedure of Feigl's spot test bromine water oxidates I- and changes it into iodate. Adds sulfosalicylic acid on this and the excess of bromine is decomposed Then applies the Ultramicro-I₂-Hydrazine AZM and the amount of I- will de calculated retroactively.
Characteristics
a) Since excess of sulfosalicylic acid exsists, sulfuric acid is not needed to add for the Purpose of iodine liberation.
b) By the introduction of carbon dioxide gas the trace of bromine vapor in the Azotometer will be removed and so there will be no reaction between bromine and potassium iodine reagent.
This new ultramicro method is able to determine 1-10γ of I- with the deviation of ± 5%.
2) Ultramicro Determination of Oxalic Acid
In the acid solution of sulfuric acid being added by Mn⁺⁺, reacting with oxalic acid, permanganate will be quantitatively redacted. Then as reported previously, permanganate will be measured by the I₂-H ydrazine-Azotometer. For this purpose, without adding oxalic acid, the volume of permanganate in the reagent will be determined.-(γ) Then a part of permanganate, which has been reduced by oxalic acid, will be determined by the AZM.-(β) The volume difference of γ-β is proportional to the amount of existed oxalic acid.
This ultramicro method is able to determine 0.25×10^-3 mol, 1ml-10^-4 mol, 1ml of oxalic acid with the possible error of not more than 5%.
3) Ultramicro Determination of Ca⁺⁺
The principle of the Ultramicro-oxalic acid determination is adapted. In addition to this AZM, the author devised an apparatus which allows calcium oxalate to form precipitate, to collect quantitatively and dissolute easily and accurately.
Procedures
a) pH of Ca⁺⁺-solution is adjusted to 5.
b) The precipitate of calcium oxalate is formed by adding excess of ammonium oxalate.
c) The precipitate is filtered, washed by cold water and dissolved with sulfuric acid, liberating the oxalic acid.
d) The oxalic acid is determined by the application of the Ultramicro-oxalic acid-AZM.
e) The amount of Ca⁺⁺ is calculated retroactively. This method is possible to estimate 10-3γ of Ca⁺⁺ with the deviation of ± 3-4%.

View full abstract

For about 6 months before, during and after the administration of a new drug named Phenelzine (Ep 411), the writer investigated the effect of the drug on 16 out-patients and 4 in-patients of our clinic who were in depressive states. Each patient, for three times a day with each meal, was given a tablet which contained 15mg of Ep 411. Main results obtained are as follows.
1) The administration of the drug had a favorable influence on inhibition, however, had much less response on physical symptoms or sensations.
2) Among various kinds of depressive states marked reaction was noticed on neurotic depressive symptoms, while less reaction was noticed in periodic or phasic psychosis of the manic depressive type.
3) Since Ep 411 has both sedative and stimulating effects for mental symptoms this remedy has distinctive features.
4) Generally speaking, Ep 411 has minimal side-effects. In summary, Ep 411 is deemed to be superior to any other antidepressant from the standpoint of its margin of safety.

View full abstract

Due to the progress of chemotherapy, antibiotics and techniques of anesthesia as well as surgical operations, recently the treatment for pulmonary tuberculosis has greatly changed.
Studies were made on one hundred cases of pulmonary resections performed at the Otaru National Sanatorium from January 1955 to March 1959.
The authors investigated particularly on the following points such as;
a) Resection in comparison with thoracoplasty.
b) Relation between the size of pulmonary resection, postresective thoracoplasty and postoperative pulmonary function.
c) Examination on the postoperative complications.
d) Follow-up result.
The results obtained were satisfactorily.

View full abstract