Acid phosphatase activity of mycobacteria was studied by several investigators. Recent abvance in mycobacterial taxonomy added a number of mycobacterial species to our knowledge, and Group II and Group III mycobacteria, which had not yet noticed as the species at the time of the above studies, were subgrouped into several species. In view of this state, it appeared to be desirable to study the acid phosphatase activity in the mycobacteria including recently defined species.
The method used is shown in Table 1. It is a simple method, in which the phenol reagent was used for colouring of phenol liberated from substrate, phenyl disodium phosphate. Instead of bacterial suspension prepared quantitatively, one loopful of the stock culture was used as the enzyme material, as a preliminary experiment showed that the use of bacterial suspension did not give much merit for obtaining reliable results (Table 2). The results are shown in Table 3.
The measurement of acid phosphatase activity seemed to be useful for the following purposes:
1) Differentiation of M. scrofulaceum from M. gordonae, and differentiation of M, szulgai from M. gordonae;
2) differentiation of M. xenopi from other members of Group III;
3) differentiation of a group of M. smegmatis, M. chelonei subsp. abscessus and M. agri from a group of M. thermoresistibile, M. phlei, M. fortuitum, M. chitae and M. chelonei subsp. chelonei;
4) differentiation of G. broncialis from other Gordona species.

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Pancreatic carcinoma is frequently metastasized to general organs hematogenically, but relatively rare to the skin. We report a case of pancreatic carcinoma with skin-metastases, and review metastases of this cancer.
A 73-years-old female visited our clinic with epigastric pain and skin nodules at abdominal wall. The skin nodules were examined histologically and diagnosed as anaplastic adenocarcinoma of obscure origin. During the hospitalization she developed liver swelling, subcutaneous edema of lower half of body and ascites. She expired after progressive wasting.
Post mortem examination disclosed carcinoma of pancreas with extensive metastases to liver, gall-bladder, adrenal glands, thyroid gland and skin. The histological examination revealed anaplastic adenocarcinoma.

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Phenformin-Retard-Capsule and Dipar were administeredd on 30 cases of diabetics to compare the hypoglycemic action and side effect. The breakdown of 30 cases were 10 cases administered with Dipar only, 8 of the co-use with sulphonylurea preparations and 6 with insulin therapy. The results are as follows:
1. Hypoglycemic actions: the efficacy of two preparations was about that same.
2. Side effects: the side effects of two preparations were mainly gastrointestinal disturbances. The side effects occurred in 10 cases with Phenformin Retard-Capsule, while only 3 were observed with Dipar.

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Since May 1971, five cases of ischemic heart diseases have been treated by surgical procedures in Osaka National Hospital, Cardiovascular Surgery.
There were four men and a woman whose ages ranged from 30 to 62 years. One case of left ventricular akinesis complicated with aortic insufficiency, two cases of angina pectoris at rest, and two cases of left ventricular aneurysms were involved. For these ischemic heart disease, associated operations were performed in two cases, namely removal of left ventricular asynergy lesion associated with aortic valvuloplasty and aortocoronary artery vein by-pass in addition to aneurysmectomy, only aortocoronary artery vein by-pass was performed in two cases, and only aneurys-mectomy was performed in one case respectively. All patients of this series have recovered their ordinary activities and their prognoses range from 6 to 23 months postoperatively.
Surgical procedures for coronary artery diseases such as angina pectoris and myocardial infarction have been commonly appreciated to be most clinical effective treatment to them in the United State and Europe. On the other hand, in Japan, direct operative treatments to these ischemic heart diseases are not popular. It may be cited that selective coronary arteriography and left ventriculography, which are essential clinical techniques to select the patients with coronary artery diseases, have not yet standardized and evolved in addition to low morbidity of these disorders in our country.
In Japan, it can scarcely be found reports of natural history of patients afflicted with ischemic heart disease. According to Kato, et al. and Tomomatsu, et al., it is high mortality rate not only in the second attack of myocardial infarction but also in acute myocardial infarctions with complications. 58 per cent of patients with angina pectoris went on to develop myocardial infarction in acute phase, and about 40 per cent of these patients died.
Up to today, we have no equipment of cine-coronary arteriography in Osaka National Hospital, but, if such an apparatus equipped with, patients with angina pectoris require selective cine-coro-nary arteriography and left ventriculography for an accurate anatomic diagnosis in Order to select the patients for surgical treatments, and for their postoperative evaluation. In order to lessen the operative risk, we have taken the following new maneuver of cardiovascular by-pass during operation. First, even though not occluding caval catheters by caval clamp or ligation, perfect extracorporeal circulation can be operated, second, Apico-Aortic cannulation.
To shorten the operation time and to simplify the operative maneuver is to lessen the operative risk.

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We used the feeder for 12 advanced Duchenne type progressive muscular dystrophy. After the trial, increased functional capacity were obtained in all cases. The feeder should be tried for the rehabilitation of the patient with progressive muscular dystrophy.

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A 6-years-old girl without deafness who was in good health until age 5.5 years when she had first syncopal attack in running. At six years old she had second syncopal attack for 20 minutes in dancing. Electrocardiogram taken on same day showed sinus arrythmia, wandering pacemaker and marked prolonged QT interval (QTc=0.7 second). Both electroencephalogram and serum electrolytes showed no abnormality.
At 6.5 years old she suddenly died with third syncopal attack in running.
Family history was not contributory.

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I reported a case of aseptic necrosis of Os capitatum. The patient was a student nurse of 19-years-old. She began to feel weakness and pain on the right wrist after minor trauma. There was no sign of inflammation, but X-ray demonstrated rarefaction and destruction at distal portion and sclerosis at proximal portion of Os capitatum.
Operation was performed by excision of lesion and intercarpal bone-fusion with grafting.
Histological finding revealed necrosis of bone, proliferation of connective tissue with many vessels and metaplastic ossification. This case was the first report in Japan.

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