The author asserts strenously that the occurrence of th a rheumatoid arthritis have been frequently related with hereditary constitution in the rheumatic strain.
1. There are two rheumatic families; in every strains many rheumatic patients are found and it is proved that the occurrence of rheumatoid arthritis is related with hereditary predisposition lying in their strains.
In the first family, there are seven patients, in whom five patients are female, In this strain hereditary predisposition would be produced through nearly related intermarriage for several generations.
In the other famlly, there are five cases of rheumatic disease, in which four famale patients are found among 6 siblings.
2. X-ray findings of joints, mainly of the wrist, knee and ankle, revealed fibrous and bony ankylosis, swelling and deformities of joints, destruction and rarefaction of bones, and atrophy of periarticular tissues.
3. The treatment for the rheumatoid arthritis is unsatisfactory at present about the point of recovery from the diseases, for which the establishment of the public health center for rheumatic disease is quite urgent for the purpose of treatment and rehabilitation.

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1) Therer are remarkable individual differences among active INH serum concentrations, in which the mean value is slightly higher in male than in female, and lower in Japanese than in Europeans. The metabolic pattern does not change in rabbit regardless of its affection of tuberculosis.
2) The value of active INH in serum increases on administration of PAS, sulfas or glucosamin at the same time. On some cases, there is no influence of these drugs.
3) The value of active INH in serum increases and is maintained much longer in the case of liver dysfunction both in human and rabbit. This may be due to the compensatory increase of free hydrazone type of INH, that is caused by decreased acetylation in the affected liver.
4) The value of active INH within organs of rabbit reveales a marked individual difference and the highest value is obtained in the kidney and next in the lung, liver, blood, brain and in the spleen in the decreasing order and decreases as the time passes by, just parallel with that in the serum. When the INH dosage is above 12mg/kg, the order changes as follows; the kidney, brain, blood, lung, spleen and liver. The same tendency is observed in liver when INH is administered together with PAS, sulfas or glucosamin.
5) S type is observed in the patient who is strongly resistent to INH, while R type is observed in the patient who is moderately resistent to INH and in the patients who experienced burst during the course of INH therapy.
6) The value of active INH in the caseous substance of lung lesions is highly related to the softend conditions of caseous substance, and that is not related to the capillary proliferation of wall.
7) Anti-INH substance is detected in tubercular Gaseous substance, culture filtrate, decomposing products of tubercle bacilli and serum of patient. The amount of that is seen more in INH resistent bacilli than in sensitive bacilli, and more in the patients than in healthy persons.

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The cardiopulmonary function tests including the intravascular catherization were performed on 25 cases of pulmonary tuberculosis and 5 cases of non-tuberculous pulmonary disease. Among them 20 cases were subjected to the anoxia test in addition.
1) There was slight elevation of the pulmonary arterial pressure in the pulmonary tuber-culosis. It was observed that there was a tendency to increased pressure in those cases, in whom the predicted VC was less than 60%, predicted MBC less than 50% and TVC less than 1, 000cc.
2) Increased pressure of the pulmonary artery was seen in the case showing hypertrophy of right ventricle on E. K. G.
3) The cardiac index was increased in the case of patient having a systolic murmur at the base of the heart. The heart murmur was recorded on a phonocardiogram. It is considered that a systolic heart murmur in pulmonary tuberculosis is produced by a volume load of the heart.
4) During the anoxia tests elevation of pulmonary arterial pressure and increase of cardiac index were observed, but in some far advanced cases elevation of pressure and decrease of cardiac index were observed.

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We have treated 38 epileptics with Resochin and obtained the following results.
1. In 8 out of 12 cases who had only petit mal seizure the administration of Resochin alone gave a remarkable effect.
2. Among 14 cases who had grand mal accompanied with petit mal and had been treated with Resochin with together other anti-epileptic agents, we found a marked effect in two of them and decrease in it's frequency of attacks in four.
3. In six epileptics complaining with headache the administration of Resochin alone proved to be markedly effective in five of them.
4. In contrast to the above, in five cases who had only grand mal, we found that neither the administration of Resochin alone nor that of Resochin with other anti-epileptic agents together proved to be effective, In some, actually such a combination therapy rather aggravated attacks that we had to withdraw the Resochin treatment.
5. Dr. Wada has stated that the combination of Resochin with other anti-epileptic agents was effective on the psychomotor seizure, but we have not encountered with such a case unfortunatly.

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Tuberculous patients are, as a rule, availably treated on account of public expenditure, according to the Tuberculosis Protection Law. Usually the medical disposition is decided by the Tuberculosis Committee Council at the respective district Health Center, although that is proposed by physicians. The author has attended the meeting at “Mutsu” Health Center and has fortunately had chances of inspecting the chest X-ray findings of tuberculous patients in Shimokita Peninsula from Jan., 1958 through Dec., 1963.
The author classified these findings by means of N. T. A. (National Tuberculosis Association) -method and of W. H. O. classification. These results are compared in 8 districts, (one city and 7 towns and villages), and also in 3 kinds of medical facilities, namely G. P. D., provincial hospitals and national sanatoriums. Then, calculating the percentage of far advanced cases, owing to the N. T. A. classification and that of cavity existence and the mean value of W. H. O. method in each year and in each district.
1. In relatively rural parts of the peninsula, directly facing to Pacific Ocean and to “Tsugaru” Strait, the percentage of F. A. cases was numerous at around 1958, but decreased year by year recently. It is probably suggested that medical knowledge about tuberculosisand social security countermeasures have been populized into the inhabitants of this county. Such a matter can be demonstrated in the results of cavity existence and of W. H. O. -classification.
2. As for the kinds of medical facilities, the advanced cases have been mostly admitted in national sanatoriums. Here, the percentage of F. A. cases is twice as much as G. P. D.. This trend has had no change during past 6 years, but the case seriousnes in provincial hospitals has always been between the former two.

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