Considering the relation to the general pathology, skin tumors were classified on the basis of the embryology as follows:
1) the ectodermal epithelial tumors tumors of the surface epidermis tumors of the epidermal appendages
2) the ectodermal nervous tumors tumors of the melanocyte tumors of the nerve tissue
3) the mesodermal nonepithelial tumors tumors of the connective substances tumors of the muscular tissue
4) the mesodermal vascular tumors tumors of the blood vessels tumors of the lymphatic vessels
5) reticulosis
6) metastatic tumors.
In 1) -4) class, benign and malignant tumors occur.
Squamous cell carcinoma and basal cell carcinoma were described of the histological pictures of various types and differential diagnosis.
The tumors occuring from the intraepidermal parts of appendages were classified and explained the histological pictures. To add to the above, the problems of the intraepi-dermal epithelioma were discussed.
The histological pictures of nasal glioma, neurilemmoma (Antoni B type), nodular fasciitis, desmoid tumor, hibernoma, liposarcoma, granular cell myoblastoma, Kaposi sarcoma, alveolar soft-part sarcoma and metastatic carcinoma of the skin from renal carcinoma were showed.

View full abstract

Plethysmograms of the patients with hypertension were classified into three major patterns: dicrotic, delta and trapezoid wave, which appeared in the rato of 3: 2: 1.
Delta wave was seen more frequently in those with older age, higher maximum and minimum blood pressure, and in those who showed larger variation of blood pressure on changing body position.
On changing body posture from recumbent to upright position,
1) in dicrotic wave, 'incisura' comes down and makes it clearer,
2) in delta wave, 'incisura' newly appears and
3) in trapezoid wave, it transforms into arched wave or rectangular wave.
These facts show that the patterns of plethysmograms indicate the degree of the elasticity of blood vessels, which is decreasing in the order of dicrotic, delta and trapezoid wave.
Dicrotic wave indicates the normal tension of blood vessels. Delta wave indicates some circulatory insufficiency and trapezoid wave indicates more severe disturbance in peripheral circulation.

View full abstract

Arthrodesis of the hip joint should be adopted with a unique indication different from other surgical procedures, such as arthroplasty and osteotomy because of its excellency in the analgesic support of the joint, improvement in the form of gait and independency of muscular equilibrium, coupled with changes in the living style of the Japanese. Marked surgical stress, the necessity for a long-term complete rest and the difficulty in complete articular union are the shortcomings of this procedure. Through an attempt of arthrodesis of the hip joint for relatively young people according to the Davis modification, the authors fully realized that there was considerable surgical stress even though a long-term complete rest was unnecessary. The theory of compression arthrodesis originated by Key, Charnley et al, is supplemented by the idea by Roux, Hiss, Krompercher and Pauwels and Biebel that the blocking compression power of flexing force and shering force accelerates callus formation. Wustmann applied it clinically as “Kontakt Osteosynthese” and Kontak-tarthrodese. The AO group including M. Müller and Axer, Fox, Niebauer, McKee and others reported on arthrodesis of the hip joint as “Kompressionsarthrodese” respectively. On the other hand, there are too numerous surgical modifications for medial neck fracture of the femur to mention because of the difficulties of its treatment. Recently, Barnes, Kahl and Forgon reported on surgical methods in consideration of the application of compression power. Aiming at the improvement of these points, the authors have been attempting to introduce compression power to hip surgery over several years and have obtained some information through a few cases which is reported below.
The following test was attempted to find the permissible compression power of the screw together with deformities of the pelvis and the head of the femur. Dried pelvis of cadaver and fresh head of the femur were compressed using compressing bars, 10mm and 15mm in diameter, in the Amsler type test machine and the grade of deformation was obtained respectively. At the three points of pelvic space side of the dried pelvis of the cadaver, compression power ranging from about 20 to 60kg/cm² caused fissure. In the fresh pelvis, no fissure was induced by compression ranging from the minimum of 67.4kg/cm² to the maximum of 78.6kg/cm².
As compression was applied to the femoral head, the cartilage and cortex in the compressed region were easily crushed and sank into the spongiosa. Compression power of 74.2kg/cm² caused fissure in the surface of the femoral head. No macroscopic change was observed on the surface of the femoral head by loads lower than that.
Deformity of the femoral head of hip arthrosis deformans is extremely rare.
The compression screw was designed not to destruct the socket and the femoral head when compressed. It was also designed to fit the distance between the socket and the major trochanter and the surface of the femoral head to avoid inconveniences in the clinical application. An equation of relationship between torque moment and compression load was induced. The load value of the axial direction of the compression screw was obtained by calculating the frictional coefficient obtained by measurement of torque moment of the compression screw and measuring torque moment by torque driver at the time of operation. It ranged from 56.2kg/cm² to 74.2kg/cm² in human beings and was 19.1kg/cm² in dogs.
In open fixation, lateral incision was extended to the inguinal ligament and the crista iliaca. The femoral head was dislocated routinely to expose the marrow of the femoral head and the socket, and the screw was fixed between the pelvic space side of the socket and the lower part of the major trochanter so that the femoral head and the socket contact each other as much as possible in the position of th

View full abstract

Fundamental and clinical studies on supervoltage roentgenography using Mitsubishi 6 Mev linac were carried out. We called this roentgenography as linacgraphy. Linacgraphy is important not only for radiotherapeutic collimation but also for radiographic diagnosis.
Following mechanical device for taking linacgraphy was characteristic.
(1) The effective energy for the X-ray which is deduced from a measurement of halfa value layer with iron was 1.8 Mev. (2) Coil and magnet system for accelerated electron beam was installed to make small X-ray focal spot. (3) Loss time after switch on photography was only 0.1 second and exposure time was within one second. (4)Electronics timer in which every 0.05 second is graded between 0 to 1 second showed good reproduction. (5) A. F. C. (Automatic Frequency Control) worked well by the adjustment not only in the therapeutic dose range (300-200R/min/m) but also in the photographic dose range(80-30R/min/m). (6) The acryl plate of 0.5cm thickness was marked with lead at every 1cm on the isocentral plane. This plate was used for field collimation and correction. (7) Cassette holder was available at the bed to take linacgraphy on the vertical and horizontal direction.
Following studies on the photosensitive materials were performed. From the standpoint of contrast and sharpness (grain) of the linacgram and exposured dose cn the human body, two combinations of screens and film showed good results. (1) The Kyokko GS screens and industrial X-ray film (Fuji No.100 or Sakura RR Type). (2) The Kyokko GF screens and medical X-ray film (Fuji KX or Sakura New Y type). Resolution was determined by Burger phantom experiments and showed best result at film density: 1.6. Finally we decided following condition as one standard for taking linacgraphy. Exposure time: 0.3 to 0.5 second, exposured dose on the film: 150mR (medical), 230mR (industrial). Clinically, the irradiation field was corrected by the help of mark on the linacgram for field collimation. In linacgraphy of the head and neck region, the nasal sinuses, pharynx, oral cavity, larynx were clearly shown without any superimposed bony shadow. Also, lung field which is superimposed with clavicle, ribs, heart and diaphragm on the conventional chest film were well revealed on the linacgram. Highly radioopaque lung on the conventional chest film demonstrated the interior structure if air is kept in the lung. Since linacgraphy of head and neck region and chest have these characteristic advantages, it was found to be most useful for the radiographicc diagnosis. of malignant tumor. In the abdominal region, pneumo-gastrointestinal and pneumoperitoneal linacgraphy and air cysto-linacgraphy were adopted. Abdominal masses and tumors were clearly contrasted with air or gas

View full abstract

We found that in animal bearing transplantable tumor a yellow fluorescence was noted in the tumor tissue under ultraviolet light after administration with Flumejodin (Dijodoxy-mercurifluorescendinatrium, FF).
Experimental studies in the Ehrlich tumor show as follows: The Flumejodin fluo-rescence indicates the affinity to tumor tissue as well as Mercurochrome (MF) and Tetracycline (TN). The N/IO HCL dialyzed solution of Flumejodin-treated Ehrlich tumor shows the ultraviolet absorption spectra of wave length λ_max, 255 mμ and min. 238mμ, and this fluorescence spectra indicates the wave length λmax, 520 mμ with excited wave length 440mμ.
From the ultraviolet absorption and the fluorescence spectra of the fluorochrome dialyzed, it was suggested that Flumejodin in the tumor tissue conjugated with the same parts of compounds as MF and TN.
We concluded that the introduction of Flumejodin fluorescence in the study of gastro-intestinal cancer had provided new approches for detecting cancer

View full abstract

At the department of dermatology of Kumamoto University from 1963 till 1969 and at the Kumamoto National Hospital from 1968 till 1969, a total of 29075 cases of out-patients of skin disorders were examined and of those 352 cases were due to diabetic skin disorder.
In our study of these cases we used three methods 1) statistical observation, 2) clinical peculiarities and 3) its etiology.
As a result of our research it was quite evident that diabetic patients with :kin disorders had increased and since 1966 among the patients this increase was over 1%.
Of the 352 patients we examined, 211 cases had already been pointed out to us as diabetic by other clinics.
Of the remainder we ourselves discovered 139 cases of diabetes mellitus; that ratio is about 2:1, and consequently examination of skin disorder can be a great help in disco-vering diabetes.
We classified the diabetic skin disorders as follows:
1) Specific skin disorders (direct dermadrome) as is seen in the primary diabetes.
2) Skin disorders which had changed for the worse due to diabetes (indirect dermadrome)
3) Skin disorders as is seen in the secondary diabetes.
4) Skin disorders as is seen in the special type of secondary 'diabetes which were due to genetic diseases of inborn errors.
In this paper we report the direct dermadrome as is seen in the primary diabetes.
a) Skin disorders induced by carbohydrate metabolic disorders.
e. g. sclerederma adultorum
b) Skin disorders induced by fat metabolic disorders
e.g, many kinds of xanthoma especially xanthelasma palpebrarum etc.
c) Vascular skin disorders
e. g. necrobiosis lipoidica, diabetic gangrene, dermopathy in a narrow sence etc

View full abstract

The lung washings were obtained from 25 patients with pulmonary tuberculosis before and after operation. Surface tensions were measured on Wilhelmy balance and stability indexes were calculated. The relationships between the surface activity of washings and the results of the lung function tests performed at the same time were studied.
The surface activity of washings obtained after surgery was identical to that obtained before surgery regardless the loss of lung tissue.
After surgery minimal surface tension of washings inversely related with %VC and forced expiratory volume/predicted vital capacity ratio (FEV_1.0/ VC_Fred.). The stability index also correlated with %VC and FEV_1.0/VC_Fred. These relationships were not found before surgery.
The surface activity of washings were not correlated with %MVV both before and after operation.
These findings suggested that surgical procedure for pulmonary tuberculosis may change the metabolic activity of the affected lung

View full abstract

Hydroxyzine, well known drug for the efficacy on premedication treatment, has been examined to determine its efficacy on postmedication treatment at ten institutes, employing 1532 cases. The purpose is to test its lenitive, sedative and antiemetic actions, and also to test which lenitive drug is best to use together with Hydroxyzine to have most effective treatment.
The experimental results indicate that the use of narcotics with Hydroxyzine shows most remarkable effect in the patients with gastric operation, and that in the patients with other operations the use of non-narcotics with Hydroxyzine shows much greater effect than the combined use with narcotics.
The experiment further reveals that Hydroxyzine had also been effective in vomiting which often accompany by the use of narcotics, in addition to that by the use of Hydroxyzine the least frequent medications of the lenitive drug after operation could properly fullfil the purpose.
In conclusion, Hydroxyzine shows an excellent efficacy as lenitive and sedative drug, and also there is no side-effect. Hydroxyzine, therefore, is an excellent drug for postmedication treatment and then it can reduce the consumption of narcotics used for operation, probably with a great significance

View full abstract

The report on 7 cases of foreign body within the bladder including 4 cases of self introduction as a means of sexual gratification, 2 cases of insertion by the counter-sexes, and 1 iatrogenic case were added to our previously published similar 4 cases of vesical foreign body, summing up to 11 cases in total.
Some discussion and review of the literature concerning pathogenesis, clinical analysis and treatment of vesical foreign body were done

View full abstract