Based on the clinico-chemical observations made on inpatients, experimental nephrosis caused by the administration of nephrotoxin (antikidney serum) or mercury bichloride were investigated, in order to elucidate the disturbance of protein or fat metabolism, and their sequential relation to proteinuria. The results obtained were as follows:
1) In nephrosis, every components of plasma lipids increased simultaneously, except phospholipid. The increase of total lipids or fatty acids shall be attributed chiefly to the increase of cholesterol or neutral fatt.
In nephrotoxinized rats, together with clinical signs, simultaneous increases of every courponents of plasma lipids were observed as well. In case of rat, treated with mercury bichlcride, no significant increases of plasma lipids, except cholesterol, were observed.
2) In nephrosis, decrease of total protein, albumin, and γ-globulin, and increase of α, β, and φ globulin were observed. Thus the decrease of total protein in nephrosis shall be attributed chiefly to that of albumin fraction.
In nephrotoxinized rats, similar results were obtained as to plasma protein.
As for fractions of urine protein in these rats, decrease of albumin and increase of α, β. or γ globulin were observed together with the progress of nephrosis.
3) In nephrosis, amount of protein excreted in urine, body weight, total lipid, free and total cholesterol and β globulin, were parallel to each other, except albumin that was inversely to their changes.
4) Immediately after the administration of nephrotoxin in rats, proteinuria developed. In case of exclusive proteinuria with definite grade, changes of blood chemical components, such as hyperlipemia or hypoalbuminemia, and the development of edema were resulted. However in case of very slight grade of proteinuria, no sequential change was observed.
5) In nephrotoxinized rat, significant correlation between the amount of protein excreted in urine and total lipids in plasma, and then between albumin and total cholesterol in plasma were obtained. (Correlation coefficients were +0.57 and -059, respectively)
Similarly, in nephrosis, significant correlation was found between urine protein and total cholesterol in plasma. (Correlation coefficient were +0.44)
6) In rats, treated with nephrotoxin or mercury bichloride, contents of lipids in viscera. such as liver, spleen, heart or kidney, were compared with that of healthy ones, while in rats, which developed marked proteinuria by large amount of nephrotoxin, the contents of phospholipid in viscera decreased markedly, those of total lipids or total cholasterol in them showed no significant changes.
7) From these results, it may be concluded that in case of nephrotoxin-nephrosis, clinico-pa thological changes develop in sequence of degeneration of glomerulus or tubules in kidney, loss of protein in urine, hypoalbuminemia and hyperlipemia.

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The present paper deals with the. following problems; (1) EEGs of the hypertension cases in which antihypertensive drugs were effective. (2) EEGs of the hypertension cases, that had long-term oral administration of antihypertensive drugs (3) EEGs of the hyperension cases that were fatal.
As for the first problem, the rates of cases in which antihypertensive drugs were effective 82.2% in the group of normal EEGs, 85% in the group of abnormal fast EEGs, 53.4% in the group of spiked EEGs and 45.5% in the group of slow EEGs.
As for the second problem, the group of long-term oral administration showed remarkable decrease of abnormal EEGs (9 cases), slight decrease of abnormality (9 cases), no changes in EEGs (13 cases) and increase of abnormality in only 2 cases. Meanwhile, the group without drugs showed prominent decrease of abnormality in only 1 case, slight decrease of abnormality in 1 case, no changes in 16 cases and increase of abnormality in 5 cases.
As for the EEGs of the 10 fatal hypertension cases, 4 cases had remarkably slow activity (delta waves in 1 ease and theta waves in 3 cases).
In a few cases, unfavorable prognosis of hypertension could be anticipated by the changes of their EEGs.
These results may suggest that EEG can play some roll to presume the prognosis or progress of hypertension.

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Eosinophile leucocytes in the circulatory blood and in the tissues of lung, spleen and liver were investigated in normal healthy man and rabbits to which anaphylactic shock by means of typhoid vaccine or human serum had been given. Results were as follows:
1) Eosinophile counts of peripheral blood decreased, meanwhile, eosinophile leucocytes accumulated in the tissues of lung and apleen under anaphylactic condition about one hour after intravenous injection of typhoid vaccine. Eosinophile leucocytes appeared again in . the peripheral blood after the termination of the shock condition.
2) Remarkable increase of eosinophile counts in the tissues of lung and spleen, under considerably strong shock, and the same in various organs of rabbits under anaphylactic shock with human serum were observed hystologically, keeping the original eosinophile form without any destroyed images.
3) From these results, functions of eosinophile leucocytes shall be considered to be in the removal of substances produced during shocked reaction, in the protection of the attacked tissues, and in the distribution of certain substances that will stimulate the regenerative process.

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Previous literatures reported that serum buffer in leprosy cases is normal or slightly acidosis, as measured by Van-Slyke's method, and pH measurement. The present authors studies this problem by means of Eguchi's transfigured method, with hydrochloric acid of 1/50N.
Eight in-patients of various grade of leprosy and of clinical types were examined. Results were as follows:
The average value of serum buffer obtained from the total cases was 0.435cc, which is significantly different from the normal average value of 0.514cc. However, it is greater than the value of serious acidosis (less than 0.35cc) reported by Eguchi.
Average values by types of leprosy were 0.457cc in macular type, 0.442cc in neural type and 0.405cc in lepromatous type. The lowest value of 0.436cc was found in macular type and 0.322cc in lepromatous type.
By degrees of the disease, no remarkable difference of grade was found in neural type and in lepromatous type, except that between slight one and serious one.
By conditions of the illness, significant difference was found between progressivee stage and suspensive one.
E. N. L. cases showed the lowest value of all, and their average was 0.377cc.
From these results, the difference between E. N. L. and the others will be very clear. The authors recommend Eguchi's method in the examination of serum buffer in leprosy cases.

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The present paper is to report a case of lung abscess that was treated with aerosol therapy of penicillin and homosulfamin. The effects of the therapy resulted in marked improvements as to temperature, cough, sputa and x-ray picture. However, appearance of the penicillin resistant mutants of staphylococci in sputa and a considerably large cavity in the right upper lobe of the lung compelled us to perform segmental resection of the cavity.
Bacteriological examination of the resected S¹ to S² and the contents of the cavity revealed no bacteria.
The extension of the cavity was 4cm by 2cm large.

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The present paper is to report the investigation on the relation between drug resistance and clinical symptoms. As the number of observed cases was small, it was impossible to get a determined conclusion, however, a tendency as discussed in the following was observed from our results.
The combined use of PAS and INH was considered to be effective, regardless of the existence of already acquired drug resistance. When the bacilli were resistant to streptomycin, resistant to isoniazid, of resistant to both PAS and streptomycin, the combined use of PAS and INH was more effective than the cases of the bacilli that were resistant to both streptomycin and INH, or resistant to streptomycin, PAS, and INH.
The combined use of PAS and isoniazid was effective as well as the combined use of streptomycin and PAS.
The combined use of streptomycin, PAS, and isoniazid was more effective than the combined use of streptomycin, and PAS, or the combined use of PAS and isoniazid.
In cases the already acquired resistance to streptomycin, PAS and isoniazid ascended, the clinical symptoms grew worse.

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