Obesity is considered to be closely related with the development or advancement of hypertension, atherosclerosis and obesity heart disease. The main point of the dietary treatment of obesity is low calorie diet with necessary protein intake (1.0g/kg). Total daily calories should be restricted to 1, 000 (-700) calories. Fat intake should he prohibited. Daily calorie intake may be increased to 1, 300 or 1, 600 calories for the ambulatory individuals with slight or moderate work loads.
The important points of the dietary treatment of essential hypertension are low sodium, low calorie and low fat diet. Permissible daily salt intake is 5-7g, combined with the administration of thiazide drugs. Considerable hypotensive effect has been probed in such way.
The main points of the dietary treatment of atherosclerosis are low fat, low cholesterol and low calorie diet. Actual dietary regimen, however, should be individualized the following pattern of serum lipids.
The essential point of the dietary treatment of the congestive heart failure is low sodium diet. Restriction of salt intake to 3-5g per day with the administrations of cardiac glycosides and diurectics are recommended. Fluid intake need not be restricted. Spare frequent feedings of low calorie foods with high vitamine content are beneficial. Care must be taken for the development of low salt syndrome and hypopotassemia durng the course of the treatment with the strict low sodium diet.

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The authors examined hepatic functional disorder of patients, who received blood transfusion at Sendai National Hospital in 1963, 1904, 1967 and 1968. The following results were obtained.
1) The incidence of posttransfusion hepatitis with jaundice was 9.7% in 1963 and 1964, when majority of patients were received commercial blood. That was 2.8% in 1967, when most of patients were transfused deposited blood, and 8.3% in 1968, when all patients were transfused donated blood.
2) Examining hepatic function of patients, who were transfused in 1967 and 1968, every week for 6 months, the incidence of serum hepatitis and the suspected hepatitis by Yoshitoshi's definition was 21.9% in 1967 and 26.6% in 1968.
3) The incidence of hepatic functional disorder after blood transfusion was higher in cases undergoing operation of the upper abdomen than of the other parts.

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The earlier reported statistics of cholelithiasis vary by chronology as well as by area in Japan. The purpose of this report is to inform of the result of our analytical study with the 176 cholelithiasis patients who were operated at Yokosuka National Hospital in the last 8 years.
1) In recent years, of cholelithiasis cases, cholesterin faction gall stone has been increasing in Japan;and this is particularly true of urban areas. The result of our studies confirms the identical pattern of tendency at Yokosuka National Hospital.
It is interesting to note that cholesterin faction gall stone occurred more often in female than male patients. Female incidence was two times as high. Bilirubin Ca, faction gall stone was blamed for a greater number of cholelithiasis cases in which emergency operations were required or senile patients involved,
2) Incidence of cholelithiasis was two times and a half higher in female than male patients. Our finding is the highest statistics of all earlier reports in Japan.
3) There were cholecystitis with and without stone at the ratio of 13.2: 1. It is found rather high, as compared with the figures reported earlier in Japan.
4) Ninety one and four tenth percent of patients who were examined with the supersonography had the correct diagnosis, assuring that it is much better than cholangiography.
5) Senile patients accounted for 15.3% of all cholelithiasis cases, 37.5% of Suet-stone and 23.7% of emergency operation in our studies.
6) Mortality was 2.8%, claiming only patients of 64 or more of their age. The post-operative survey was conducted by us receiving the returned questionnaire from 76% of involed patients. The result shows that 2.4% of them had the post-operative obstructions.

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The open-heart surgery of 26 cases has been performed in our hospital under extracorporeal circulation.
Perfusate is diluted to 30% hematocrit during surgery.
Lactated Ringer's solution is used as diluent because of improvement of intra-operative microcirculation.
To reduce post-operative bleeding, we make an effort. The diluted blood in the machine was not infused femoral artery post-operatively, Instead of diluted blood, arm-to-arm blood (citrated fresh blood) is used soon after the operation.
By transfusion of arm-to-arm blood, hematocrit of operated patient grow up to normal value rapidly. Then we can post-operatively prevent from anaemic hypoxia and secondary acidosis.
On the other hand, arm-to-arm blood contains much thrombocytes than stored blood. This fact makes a contribution to decrease bleeding. Pot and base excess of femoral arterial blood suggest themselves adequate signs of total results of pulmonary function.
With such efforts, we found less bleeding from operative wound. An average volume of post-operative bleeding is about 10cc/kg but a case.

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The Appointment Consultation System for outpatients has been adopted at Zentsuji National Hospital (General Hospital) from July of 196 till now for about 3 years.
As a result of it, this system produced good effects for all of us, that is, relieving out-patients from confusion, reducing the time of waiting and the performance of planned consultation. At the Department of Psychiatry, particularly, we experienced the following facts as a merit of this system.
1) For new patients particularly needing examination in detail, we have sufficient time for examination.
2) Returning patients could consult us regularly, and our medical care could be consistent with their occupation.
3) The personal relations between doctor and patients became intimate.
4) Even psychotic patients could consult us regularly under this system.
5) Therefore, it was useful to prevent them from relapse and to continue treatment.

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To evaluate PASCON as an antitubercular agent, the antibacterial activity was tested comparing with PAS.
(1) The antibacterial activity of PASCON to human tuberculosis bacilli H₃₇RV strain were tested by the dilution and the vertical diffusion method using 1% Ogawa media, and the twice activity of PAS in equimolar concentration was observed.
(2) Each 2g of PASCON and PAS was administrated to a patient respectively, and the serum was taken at 2, 4 and 6 hours after the administration. The antibacterial activities of the serum were tested by the vertical diffusion method, and it was found that the inhibition zone of PASCON was shorter and showed less activity than that of PAS.
It might be presumed that by increasing the PASCON dosage to the patient an antibacterial activity of the serum was seemed to increase.

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The deaths from renal failure were investigated from the statistics of total number of death for three years from January, 1966 to December, 1968 at the 1st Tokyo National Hospital. Patients who could have survived and rehabilitated by hemodialyses, were selected from these statistics. Depending upon these inforn aticrs, we discussed on therapeutic regimen of patients with chronic renal failure.
1) Thirteen to 20 patients with renal failure expired each year, and these consisted of 5.3 to 8.4% of total deaths. Among these patients, the possible candidates for hemodialyses would be supposed 3 to 6, which consisted of 20 to 31% of total deaths due to renal failure.
2) Thus, equipment of hemodialysis, even if it might be small scaled, would be indispensable and the plan of equipment is illustrated in Table 3. Further investigation would be required in this field of study.

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A 54-year-old female was admitted to our National Sanatorium in August, 1960 with diagnosis of pulmonary tuberculosis. The disease improved gradually. Besides she had complained gastrointestinal distress such as diarrhea and abdominal pain since February, 1907. In May, 1968, gastrectomy was done and microscopic examination revealed cancer of stomach. The patient's course went gradually downhill after operation. A postmortem examination revealed double cancer in stomach and pelvic colon.
The clinical importance of the present case was discussed in comparison with reported cases in Japan.

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Three cases of pyoderma gangrenosum were reported.
Case 1: A 45-years-old female developed necrotic ulcers on the right breat, leg and left web added elevated erythemas on the face, elbow and knee. Blood sedimentation rate was accelerated, blood cell counts showed anemia, serum γ-globulin increased. The patient did'nt respond to antibiotics.
Case 2: A 50-years-old female presented gumma-like lesions on the left leg and breast. Results of biological and biochemical examination were almost normal. The patient was responded well by anginin (2, 6-pyridine dimethanol bis n-methylcarbamate).
Case 3: A 40-years-old male, multiple granulomatous eruptions presented on his both legs for 20 years. These lesions effected by administration of anginin.
Reported cases were not associated with colitis ulcerosa, and histologic picture showed non-specific chronic inflammation.

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