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Volume 26, Issue 2
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
1977 Volume 26 Issue 2 Pages Cover17-
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Cover
1977 Volume 26 Issue 2 Pages Cover18-
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Bibliography
1977 Volume 26 Issue 2 Pages Misc5-
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
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Shiro InoueArticle type: Article
1977 Volume 26 Issue 2 Pages 55-59,104
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSeasonal variations of histamine hypersensitivity of airway were examined through 4 seasons in a year on 48 asthmatic children on institutional therapy. Histamine dose-response curves were drawn and the cumulative dose required for a 20% reduction from base line pulmonary function in peak expiratory flow rate using Wright's peak flow meter was calculated and designated histamine threshold. The threshold dose was foud lowest in autumn. Five to sixfold more histamine doses were necessary to produce bronchial reaction in spring, summer and winter than in autumn. From this results, exacerbations in asthmatic attack in autumn may be attributable to increased airway hypersensitivity caused by weather conditions such as temperature, humidity, atmospheric pressure, etc of this season. Effect of growth on airway hypersensitivity were examined on these children and found improved much after residentioal therapy for one to three years. But histamine threshold still remained in abnormal range in all patients. Also on some patients, no improvement in histamine hypersensitivity was found even after one to three years free from moderate asthma.View full abstractDownload PDF (668K) -
Takaaki Nisido, Nobuyuki Miyasaka, Masaharu OkudaArticle type: Article
1977 Volume 26 Issue 2 Pages 60-65,104
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe skin reactivity to the supernate of human lymphocyte culture stimulated by phytohemagglutinin (PHA) was observed in guinea-pigs and lyphocyte donors themselves in order to study the biological activity of skin reactive factor (SRF), one of lymphokines. The result was correlated to that of the PHA skin test. 1) The SRF skin reaction reached the peak intensity 8-12 hours after injection, and disappeared almost entirely in 48 hours. Histologically, it was characterized by perivascular inflammation accompanied with pleomorphic cellular response. 2) When tested in guinea-pigs, the SRF activity was positive for the supernate from 60.0% of 30 cases with positive PHA skin test and from only 4.6% of 22 cases with negative test. The autologous SRF activity was positive in 53.9% of 13 PHA-positive cases and in 18.2% of 11 PHA-negative cases. The defference in positivity of the SRF test between PHA-positive and-nagative cases was significant for both guinea-pigs and patients. The present observation suggests a possible role of SRF in skin reaction to PHA and its value in evaluation of cellular immunity.View full abstractDownload PDF (1474K) -
Takao NishimuraArticle type: Article
1977 Volume 26 Issue 2 Pages 66-75,105
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA large amount of tritiated native DNA (N-DNA) with high specific activity was simply and rapidly prepared by mixing N-DNA with actinomycin D (^3H) (AM-N-DNA) in vitro, and was used as hot antigens for all types of assays. The ammonium sulfate method, Farr's assay, was a simple, reproducible and quantitative technique that was sensitive and specific enough to detect a broad spectrum of antibodies to native DNA. The solid-phase immunoassay was also capable of detecting the antibodies to N-DNA. The values obtained by this method, however, were rather poorly reproducible compared to the results from the ammonium sulfate method. The millipore filter assay using AM-N-DNA failed to reveal the antibodies to N-DNA by the non-specific fixation of actinomycin D(^3H) itself to the millipore filter membrane. These findings suggest that the ammonium sulfate methods, particularly the use of native DNA combined with actinomycin D(^3H) in vitro is an excellent and suitable technique to detect the antibodies to native DNA as a routine clinical work.View full abstractDownload PDF (1202K) -
Satoru Oka, Toshihiko JyoArticle type: Article
1977 Volume 26 Issue 2 Pages 76-84,105
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA sensitive radioimmunoassay method for quantitative determination of sea-squirt antigens in vitro was developed. A purified sea-squirt antigen, Ei-2, was labeled with ^<125>I and the labeled Ei-2 was further refined by means of affinity chromatography using an immobilized rabbit anti-Ei-2 antibody. The refined labeled Ei-2 had a high affinity to the antibody and the radioactivity was high enough to use as tracer. A mixture of 100 μl of appropriately diluted refined labeled Ei-2 as a tracer (about 10000 cpm) and 50 μl of a sample solution (0.5-20 μg antigen/ml) were reacted with 50 μl of diluted (1:10) rabbit anti-Ei-2 serum for 16 hr at room temperature. At the end of the reaction, 400 μl of 20% Na_2SO_4 was added and the mixture was allowed to stand for 1 hr at room temperature, then centrifuged at 3500 rpm for 5 min. After aspirating off the supernatant, the precipitate was counted for radioactivity. From the ratio of antibody-bound radioactivity (B) in the presence of unlabeled antigen to that obtained with the tracer alone (B_o), the amount of antigen in the sample was determined by the use of a standard curve (B/B_o-standard Ei-2 concentration). It was also found that the other antigen, Gi-2, cross-reacted to the anti-Ei-2 antibody. Therefor, this assay method was considered to be applicable not only to Ei-2 but also in general to sea-squirt antigens.View full abstractDownload PDF (831K) -
Tsutomu Saga, Susumu SuetsuguArticle type: Article
1977 Volume 26 Issue 2 Pages 85-92,106
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSeven patients with aspirin-induced asthma were challenged with intravenous injections of sulpyrin, inhalations of sulpyrin and of aspirin. Forced expiratory volume in one second (FEV_<1.0>) and clinical symptomes were recorded serially. Inhalation of sulpyrin solution induced bronchoconstriction in all of the seven patients with a concentration ranging from 3 to 50 mg/ml. Maximal effect was obtained 30 minutes after the inhalation with no systemic symptomes but bronchoconstriction. There were significant correlations between the threshold levels for the three challenge tests studied. Further more, correlations between these threshold levels and severity of asthma were also significant. Our results are compatible with the hypothesis that aspirin-induced asthma is related to the inhibition of prostaglandin syntheses at smooth muscle and store cell of chemical mediators. In one of the seven patients, gold therapy was effective in improving bronchial asthma with reducing hypersensitivity to sulpyrin.View full abstractDownload PDF (1200K) -
Kentaro Higuchi, Shunji Nakagawa, Mitsue KatsudaArticle type: Article
1977 Volume 26 Issue 2 Pages 93-103,106
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn America the maps and calendars have been made for the air-born pollen under the name of hay fever and used as a warning for the patients. Although there was heightened interest in pollinosis in Japan after the II world war and sampling of pollens were begun in various sections of the country, no maps or calendars were made which covered the extensive areas. Since August 1972, the authors started collecting pollens under the auspicies of allergists in West-Japan. The surveys were conducted in the Kyushu area for 3 years and in the Chugoku and Shikoku areas for one year and the data were obtained on atmospheric pollens according to the standards of the American Academy for Air-born Allergen Surveys. The pollens were carried in the air for II months of the year or throughout the year. According to our findings, in the tree season, Japanese ceder (Cryptomeria joponica) ranked first, which was followed by pines (Pinus spp.). In the grass season (or Gramineae season) less pollens sheded relative to in the tree season. In the weed season, no pollens of short ragweed (Ambrosia elatior) were found, but those of wormwood (Achillea princeps), nettle (Urticaceae) and Japanese hop (Humulus japonicum) dominated. As th special pollens, there were Casuarina equisetifolia in Okinawa.View full abstractDownload PDF (1320K) -
Article type: Bibliography
1977 Volume 26 Issue 2 Pages 104-106
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
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[in Japanese], [in Japanese]Article type: Article
1977 Volume 26 Issue 2 Pages 107-108
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 2 Pages 109-111
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 2 Pages 113-115
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
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Article type: Cover
1977 Volume 26 Issue 2 Pages Cover19-
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (33K) -
Article type: Cover
1977 Volume 26 Issue 2 Pages Cover20-
Published: February 28, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (33K)
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