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Volume 29, Issue 9
Displaying 1-13 of 13 articles from this issue
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Article type: Cover
1980 Volume 29 Issue 9 Pages Cover33-
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (32K) -
Article type: Cover
1980 Volume 29 Issue 9 Pages Cover34-
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (32K) -
Article type: Bibliography
1980 Volume 29 Issue 9 Pages Misc11-
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (285K) -
Takehiko Matsui, Tokuko Mukoyama, Minoru BabaArticle type: Article
1980 Volume 29 Issue 9 Pages 805-815
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe prognosis of 187 asthmatic children whose asthma had begun 15 to 28 years earlier was studied by questionnaires. The final prognosis was: cured, 39.0%; almost no attacks, 28.9%; mild, 19.3%; moderate, 8.6%; severe, 2.7%; died, 1.6%;it depended on the severity of the asthma at the first visit to our hospital and on the presence of allergic rhinitis. The prognosis was not affected by the age of the onset of asthma, by the method of theraphy or by the history or presence of associated atopic diseases except allergic rhinitis. Of 92 patients, 17(18.5%)reported that they had chosen special professions because of their asthma. During the age of 12 to 18 years many patients were cured of their asthma(average-15-1/2 years). An average of 13.2 years was necessary to obtain relief. Relapse was observed in 16.0% of the parients. In all patients who died, asthma was severe from the onset, being of the perenial type and steroid dependent.View full abstractDownload PDF (1468K) -
Masamichi IshizakiArticle type: Article
1980 Volume 29 Issue 9 Pages 816-826
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAnti-rat thymocyte serum(ATS)was raised in rabbits by immunizing them with Wistar rat thymocytes. After in vivo administration of ATS to rats or application of ATS to frozen rat kidney sections, ATS was found to be strictly confined to the glomerular mesangium, as determined by immunohistological methods. ATS absorbed by rat thymocytes and brain homogenate failed to show such activity. The presence of mouse Thy-1・1 antigen in rat thymocytes, brain and other cells is known. Therefore, anti AKR Thy-1・1 C3H serum was tested in the same way. Anti Thy-1・1 serum also localized in the rat glomerular mesangium in vitro. As the previously used sera contained poly-clonal antibodies, mono-clonal Thy-1・1 antibody derived from hybrid myeloma was finally used in this study. Immunohistological methods also demonstrated localization of this antibody to rat glomerular mesangium in vitro. We conclude that the antigen common to both the glomerular mesangium and thymocytes is the Thy-1・1 antigen. The localization of ATS to rat mesangial cells after i.v.administration, was followed by degeneration or disappearance of occasional mesangial cells in the glomeruli. Thereafter, surviving mesangial cells and mesangial matrix began to proliferate in places, resulting in focal glomerulonephritis.View full abstractDownload PDF (3548K) -
Saizo Yanaura, Hidetoshi Mito, Aiko Kobayashi, Tomoo Nishimura, Fujio ...Article type: Article
1980 Volume 29 Issue 9 Pages 827-835
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe pharmacokinetics of theophylline, following oral administration of aminophylline, were studied in ambulatory bronchial asthmatic children by a simplified monitoring plan. Plasma and salivary theophylline were measured simultaneously to determine whether saliva values might be substituted for plasma values. Prior to designing the simplified monitoring plan to be used on children, normal adults were studied. In asthmatic children, the theophylline concentration and peak flow rate were measured at 1, 2 and 4 hours after the administration of aminophylline. There was a large interindividual variation in the half-life(t1/2)and clearance(CI)of theophylline. In children, the mean t1/2 was shorter and CI higher than on adults. Theophylline absorption in children with, tended to be more rapid than in children without, asthmatic attacks. On the otherhand, patients with, tended to manifest a shorter time to peak plasma concentration than patients without, past adverse reactions to theophylline. There was a correlation between theophylline concentration in plasma and saliva and the salivary-plasma theophylline concentration ratio(S/P ratio)was equivalent at 2 and 4 hours post administration. The simplified monitoring plan applied to children was practical and made it possible to determine the individual pharmacokinetics quickly. Our results suggest that at only 2 and 4 hours after oral administration, the saliva theophylline concentration indirectly reflects the plasma concentration.View full abstractDownload PDF (1031K) -
Kazuo OshimiArticle type: Article
1980 Volume 29 Issue 9 Pages 836-846
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSKiller cells with cytotoxic activity against natural killer(NK)-sensitive target cells were generated when C3H or C57BL/6 mouse spleen cells were cultured in vitro. The maximum level of cytotoxicity was observed around the 4th day of culture, and higher cytotoxic activity was observed when effector cells derived from MLC were used. In short-term cultures of 4 to 48 hours, the cytotoxic activity of fresh spleen cells did not decline, but rather increased, suggesting that NK cells do not lose their cytotoxic activity during the in vitro culture. When 4-day-cultured spleen cells were treated with nylon wool column or carbonyl iron, NK-like cytotoxicity was slightly diminished. Treatment with anti-Thy-1.2 antibody plus complement resulted in 15% suppression of NK activity of C3H mouse spleen cells, whereas NK-like killer cell activity generated in in vitro cultures was suppressed by 35 to 40%. Treatment with anti-asialo GM_1 antibody plus complement did not suppress the cytotoxicity of in vitro culture-generated NK-like killer cells in contrast to 90% suppression of the NK cell activity. Culture of NK-depleted spleen cells substantially reduced the generation of NK-like killer cells. These results might suggest that during the in vitro cultures, asialo GM_1 -positive NK cells change to asialo GM_1 -negative cells and Thy 1-negative NK cells partly change to Thy 1-positive cells.View full abstractDownload PDF (1365K) -
Yoshifuji Matsumoto, Keiko EguchiArticle type: Article
1980 Volume 29 Issue 9 Pages 847-853
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo investigate the applicability of the leukocyte adherence inhibition(LAI)test in patients with autoimmune thyroid diseases; chronic thyroiditis and Graves' disease, tests were performed with peripheral blood leukocytes from 26 parients and 20 normal individuals by using antigens such as purified thyroglobulin(TG)and thyroid microsome fraction(MS). The optimal antigen dose was proved to be 0.25 mg/ml of TG or MS-this antigen concentration did not inhibit adherence of normal leukocytes. The positive rate of LAI test against TG in the patients with autoimmune thyroid diseases was significantly higher than in normal individuals, but there was no significant difference in LAI indexes between them. LAI indexes and positive rates of LAI test against MS were significantly higher in patient group than in the normal individuals. The patients were divided into two groups of thyroid diseases; chronic thyroiditis and Graves' disease. In the patients with chronic thyroiditis. LAI indexes and positive rates of LAI test against MS were significantly higher than in the normal individuals, but there was no significant difference in those against TG. Moreover, in Graves' disease patients LAI indexes and positive rates against TG and MS were significantly higher than in the normal individuals. The results of LAI test for TG did not correlate with those for MS. There was no significant correlation between LAI indexes and titers of anti TG or MS antibody, thyroid functions(hyperthyroidism, euthyroidism and hypothyroidism), or administration of thyroid hormone and antithyroid drugs. These results indicate that LAI test may detect cell-mediated immunity directed at TG or MS in autoimmune thyroid diseases.View full abstractDownload PDF (821K) -
Katsumi Akagi, Yoshiro Tanizaki, Kiyoshi Takahashi, Masao Hosokawa, Yo ...Article type: Article
1980 Volume 29 Issue 9 Pages 854-862
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSParanumerical changes of blood monocytes were examined using a new direct counting method in 130 asthmatic patients. The results obtained in this study were as follows. 1) The numver of blood mnocytes in non-attack stages of bronchial asthma was less than that of healthy subjects, but a statistical significance between both groups was not present. 2) Monocyte count in all cases showed a significant increase in pre-attack and in attack stages. 3) In an individual asthmatic cycle, the numver of monocytes tended to increase moderately in pre-attack stages and even more markedly during asthma attacks. 4) Changes in the number of monocytes in cases with positive bronchial challenge for house dust extract showed the same tendency as in spontaneous asthma attacks. 5) The number of monocytes did not change in bronchospasm provoked by inhalation of acetylcholine. 6) Changes in the number of monocytes for exercise-induced asthma patients seemed to follow no particular pattern. That is, some cases showed a significant increase in the number monocytes related to the asthmatic cycle, but other cases did not show any changes. These findings suggest that the number of monocytes may change in asthma attacks caused by allergic reactions.View full abstractDownload PDF (844K) -
Article type: Appendix
1980 Volume 29 Issue 9 Pages 863-868
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1980 Volume 29 Issue 9 Pages 869-
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1980 Volume 29 Issue 9 Pages 871-874
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (290K) -
Article type: Cover
1980 Volume 29 Issue 9 Pages Cover35-
Published: September 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (245K)
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