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Volume 35, Issue 10
Displaying 1-12 of 12 articles from this issue
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Article type: Cover
1986 Volume 35 Issue 10 Pages Cover4-
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (301K) -
Article type: Cover
1986 Volume 35 Issue 10 Pages Cover5-
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (301K) -
Takanobu Kurashige, Hideo Morita, Fumihiko Hamada, Isamu KitamuraArticle type: Article
1986 Volume 35 Issue 10 Pages 997-1002
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSNatural killer cell activity in children with bronchial asthma and their parents was examined using K-562 cells as the target cells. NK cell activity was significantly low in children with bronchial asthma and their fathers compared with the age-sex-matched control group, but it was not significantly different in their mothers. These results suggest that low NK cell activity in children with bronchial asthma may be a genetic trait received from their fathers. No differences could be found between the subjects and the control group concerning the presence or absence of allergic anamnesis. Augmentation of NK cell activity by interferon-alpha was found not only in the control group but also in parents of children with bronchial asthma.View full abstractDownload PDF (646K) -
Toshihiko Jyo, Masao Kuwabara, Yoshiyuki Kodomari, Takashi Katsutani, ...Article type: Article
1986 Volume 35 Issue 10 Pages 1003-1010
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSHoya (sea-squirt)-asthma is an occupational disease observed among oyster-raisers. Over a period of 21 years(1963-1984), many devices were introduced in an attempt to protect the workers at the oyster-shucking plant in Hatsukaichi, Hiroshima Pref. These devices included a joint workshop, an oyster-washer, an irrigation-pool for oyster-shells, an improvement in the mallets used for shucking whereby scattering is reduced, a half facepiece for workers to prevent facial exposure and hyposensitization for workers already suffering from Hoya-asthma. A study was conduced to evaluate the effects of these devices on the prevalence rate of Hoya-asthma. 1) The prevalenc rates of Hoya-asthma in 1963, 1968, 1976 and 1984 were 36.0%, 18.7% 15.8% and 7.4%, respectively, showing a marked decrease over the years. 2) The percentage of severe cases among the Hoya-asthma patients were 28.8%(1963), 2.7%(1968), 2.7%(1976), 0%(1984), also showing a marked decrease. This was accompanied by an increase of mild cases(34.8%, 78.4%, 75.7%, 88.2%, respectively for the same years as above). 3) The specific IgE level in sera of the Hoya-asthma patients went down during the off-season when there's less chance of exposure to antigens, compared with the level during the oyster season. The specific IgE level in the sera of 4 cases without asthma-attack even after the cessation of hyposensitization, showed a year-by-year lowering tendency. 4) On the other hand, on an island where workers receive insufficient workplace protection, the prevalence rate of Hoya-asthma in 1984 was as high as 37.9%. We conclude that an improvement in environmental working conditions produces favorable effects on occupational asthma, such as a decrease in the prevalence rate, a reduction of severity and a lowering of specific IgE levels in sera.View full abstractDownload PDF (877K) -
Osamu Kitada, Minoru Sugita, Mieko Kawasaki, Joichi OnoArticle type: Article
1986 Volume 35 Issue 10 Pages 1011-1021
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSContinuous changes in respiratory impedance using Astograph and ^<81m>Kr ventilation image during methacholine solution of serially doubling concentration and salbutamol inhalation were simultaneously measured in 18 adult asthmatics. Bronchial sensitivity was evaluated at points where the initial increase of impedance and the initial decrease of ^<81m>Kr count were observed. Furthermore, in order to study the sites of airway obstruction provoked by methacholine, the pulmonary images of ^<81m>Kr during ssaline inhalation were divided into 6 regions (left and right;upper, middle and lower field) and changes in the ^<81>mKr count ratio for each region were examined during the experiments. The results showed that the following areas had the lowest regional bronchial sensitivity:one in the upper field, four in the middle field and fourteen in the lower field. This applied to 15 of the subjects. In the other 3, regional bronchial sensitivity was not clear. A significant relationshiip (r=0.862) was found between the elapsed time before initial increase of respiratory impedance and the elapsed time before initial decrease of regional ^<81m>Kr count ratio. Bronchial reactivity, defined by changes in the slope of impedance curve after impedance increased, was compared with the difference between maximum methacholine sensitivity and minimum methacholine sensitivity in all regions. Rough but significant correlation was found between them.View full abstractDownload PDF (1281K) -
Toshihiko Hori, Hiroya OhyamaArticle type: Article
1986 Volume 35 Issue 10 Pages 1022-1027
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEpidemiological examinations were carried out on 590 students at Matsukawa junior high school to reveal the actual conditions of childhood pollinosis. The results were as follows: The estimated occurrence rate of pollinosis (rate of students with both nasal or ocular allergic symptoms and positive RAST) was 9.2% for Japanese cedar pollen, 15.6% for orchard grass pollen and 2.9% for apple pollen. These rates were almost the same as those for adults living in this town. Considering the fact that the rate of students with positive RAST but without any allergic symptoms was 3.6% for Japanese cedar pollen and 9.7% for orchard grass pollen, the occurrence rate of pollinosis in this town is likely to be higher in the near future.View full abstractDownload PDF (731K) -
Kazuo Takahashi, Tatsuhiko Shono, Yasuhiro AraiArticle type: Article
1986 Volume 35 Issue 10 Pages 1028-1036
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAn, investigation was made into the effect of MY-1250: 5, 6-dihydro-7, 8-dimethyl-4, 5-dioxo-4H-phrano[3, 2-c]quinoline-2-carboxylic acid, a main active metabolite of a new anti-allergic drug, MY-5116: isoamyl 5, 6-dihydro-7, 8-dimethyl-4, 5-dioxo-4H-pyrano[3, 2-c]quinoline-2-carboxylate, on histamine release from rat peritoneal exudate cells (PEC) and the degranulation of mesenteric mast cells (MMC). When MY-1250 and DSCG were added simultaneously with antigen, both compounds suppressed the release of histamine induced by antigen antibody reaction. MY-1250 at a concentration of 10^<-6>-10^<-3>g/ml slightly suppressed histamine release induced by compound 48/80, but DSCG, at a concentration of 10^<-3>g/ml, significantly suppressed a similarly induced histamine release. Both MY-1250 and DSCG inhibited histamine release induced by phosholipase A_2. Preincubation of MY-1250 or DSCG with PEC diminished the inhibitory effect on the release of histamine induced by antigen antibody reaction and compound 48/80, but it did not influence the inhibitory effect on the release induced by phospholipase A_2. MY-1250 and DSCG produced no spontaneous histamine release from PEC, but ketotifen significantly increased spontaneous histamine release. MY-1250 and DSCG suppressed the degranulation of MMC induced by antigen antibody reaction. From these results, it is suggested that the inhibitory effects of MY-1250 on histamine release from rat PEC are similar to those of DSCG, except for the difference in the inhibitory activities of both drugs on histamine release induced by compound 48/80.View full abstractDownload PDF (1074K) -
Kazuo TakahashiArticle type: Article
1986 Volume 35 Issue 10 Pages 1037-1046
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of MY-5116 (isoamyl 5, 6-dihydro-7, 8-dimethyl-4, 5-dioxo-4H-pyrano [3, 2-c]quinoline-2-carboxylate), a new anti-allergic agent and DSCG were compared by employing the models of experimental asthma in rats and guinea pigs. Experimental asthma in rats were prepared by using rats passively sensitized with mouse anti-OVA IgE serum (PCA titer 1:4096). Variations in breathing after an intravenous injection of antigen OVA were measured and the number of breaths and the volume of breathing were calculated. Breating decreased to a standstill or to a nearly arrested condition 30 sec after challenge and rapidly improved to normal level after 10 min. MY-5116(30mg/kg, p.o.)significantly inhibited the decreases in the number of breaths and the volume of breathing during a period between 30 sec and 1 min. Similar inhibition was observed in the animals treated with DSCG(10mg/kg, i.v.). Experimental asthma in guinea pigs was prepared by using guinea pigs passively sensitized with homologous anti-BPO・BGG IgE serum (PCA titer 1:2048). Under mild anesthesia with urethane, variations in breathing after challenge were measured through a tracheal cannula, and the number of breaths, the volume of breathing and the expiration divided by inspiration ratio were calculated. After challenge, breathing continuously changed between 3 min and 3 hr; the number of breaths and the volume of breathing decreased and the respiratory ratio increased. MY-5116(30 mg/kg, i.p.)significantly improved asthmatic symptoms during a period between 3 min and 3 hr and DSCG (10mg/kg i.v.) produced a partially significant inhibition of the symptoms after challenge, but the efficacy was less potent than that of MY-5116.View full abstractDownload PDF (1006K) -
Tsukasa Iwahashi, Toshihiko Takao, Yukari Takano, Koichi Kuribayashi, ...Article type: Article
1986 Volume 35 Issue 10 Pages 1047-1055
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecombinant IL-2 (rIL-2), secreted from E.Coli harboring a plasmid and containing a synthetic IL-2 gene, is biologically active in inducing activated killer cells (AK) from mouse spleen cells. In this study, we investigeted the biological characteristics of the AK that was induced in vitro by rIL-2. AK were induced by culturing in complete medium containing rIL-2, and recombinant interferon had a synergetic effect with rIL-2. The AK exerted a killer activity on target tumors including P3 myeloma, SP2 myeloma, YAC1 lymphoma, C-26 adenocarcinoma, and BW5147 lymphoma, but not on other targets including Meth-A fibrosarcoma and RL♂lymphoma. The AK were consisted of some heterogenic groups: first Thy1-, asialoGM_^1+ cells which exerted killer activity on YAC1 target; second Thy1+, asialoGM_1+ cells which killed P3, BW5147 and C-26; third Thy1+-, asialoGM_1 cells which revealed broad killer activity on a variety of target tumors including SP2, P3, BW5147 and C-26. Each group of the AK was induced in a different period of cell culture and cold target inhibition test revealed that each had different killer activity on different target determinants. From these findings, it was concluded that the AK induced from mouse spleen cells in the presence of rIL-2 consisted of at least three groups of cells which had different characteristitics with regard to surface markers, target determinants and induction periods.View full abstractDownload PDF (979K) -
Hiroshi Hayakawa, Noboru Kobayashi, Junichi YataArticle type: Article
1986 Volume 35 Issue 10 Pages 1056-1063
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe authors reported and discussed the clinical and immunological features of 45 children registered as sufferers of selective IgA deficiency to the All Japan Immunodeficiency Registry up to September 5, 1985. Taking into account the development of the IgA system in childhood, single measurements of serum IgA levels do not always seem to be sufficient to establish the diagnosis of'selective IgA deficienty', particulary in children under 3 years of age. 14 of the 45 patients reported on (31.1%) came into this category. 22 patients (48.9%) were reported to have a marked susceptibility to infections and 9 cases were complicated with epilepsy. Autoimmune diseases such as rheumatoid arthritis and idiopathic thrommbocytopenic purpura were reported in 5 cases (11.1%) and allergic diseases including bronchial asthma and eczema were described in 11 patients(24.4%).View full abstractDownload PDF (935K) -
Article type: Appendix
1986 Volume 35 Issue 10 Pages 1064-1066
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (282K) -
Article type: Cover
1986 Volume 35 Issue 10 Pages Cover6-
Published: October 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (179K)
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