Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
Volume 37, Issue 10
Displaying 1-17 of 17 articles from this issue
  • Article type: Cover
    1988 Volume 37 Issue 10 Pages Cover3-
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Article type: Cover
    1988 Volume 37 Issue 10 Pages Cover4-
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (100K)
  • Article type: Appendix
    1988 Volume 37 Issue 10 Pages App2-
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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  • [in Japanese]
    Article type: Article
    1988 Volume 37 Issue 10 Pages 975-979
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Yoshinori Terashi, Tatsuo Yukawa, Takeshi Fukuda, Sohei Makino
    Article type: Article
    1988 Volume 37 Issue 10 Pages 980-991
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The appearance of late asthmatic response (LAR) following inhalaed antigen exposure was examined in sensitized guinea pigs by measurement of respiratory resistance using the oscillation method. Animals passively sensitized by intravenous administration of immune serum containing ovalbumin (OA)-specific IgE or IgG_1 antibody showed immediate asthmatic response (IAR), but not LAR, to inhaled antigen challenge. In contrast, animals actively sensitized by weekly repeated exposure to OA aerosol solution developed biphasic pulmonary response in 19 of 38 animals until 10th week after the first exposure. PCA assay in animals which developed LAR showed mainly IgG_1 but not IgE antibodies. Histologic study of the animals which developed LAR showed not only severe infiltration of eosinophols, but also infiltration of neutrophils during the late phase in addition to inflammatory organic changes in the bronchi. In passively sensitized animals which developed IAR alone, however, only eosinophilic infiltration was predominantly observed in the bronchi. These results suggest that (1) neutrophil recruitment with chronic inflammatory changes in the airway induced by recurrent allergen exposure may be important for the elicitation of LAR, and (2) these comparative studies between passively and actively sensitized models are useful in investigating the mechanisms of LAR.
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  • Masahiko Kato, Akihiro Morikawa, Takayoshi Kuroume
    Article type: Article
    1988 Volume 37 Issue 10 Pages 992-998
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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    We examined the activity of neutrophils to produce active oxygen species in asthmatic children using whole blood luminol-dependent chemiluminescence. Following results were obtained. 1) The peak of chemiluminescence (peak count) per 1× 10^6 neutrophlis was higher in patients with bronchial asthma during attack (n=17, p<0.005), without attack (n=19, p<0.01), atopic dermatitis (n=4, p<0.025), bacterial infection (n=3, p<0.025) than those of normal subjects (n=9). 2) The comparison of peak count per 1× 10^6 neutrophlis and peak time during attack and without attack in the same asthmatic children showed peak count during attack being higher than those without attack (n=9, p<0.01). On the other hand, peak time during attack was lower than those without attack (n=9, p<0.005). These results suggested that on asthmatic attack the activity of neutrophils to produce active oxygen species might be elevated.
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  • Kenichi Tokuyama, Makoto Shigeta, Hirokazu Arakawa, Hiroyuki Mochizuki ...
    Article type: Article
    1988 Volume 37 Issue 10 Pages 999-1006
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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    To investigate the cause of cough after awakening in asthmatic children, both the questionnaires and cholinergic function tests were employed. The answer to the questionnaires (n=196) revealed that 103 children (53%) had ever had the cough at the time (answering "always", "frequently"and "sometimes"), and the timing of cough was rather constant in each child, while it was scattered in the first 30 minutes; soon after (n=36), within 15 minutes (n=46) and 15-30 minutes after awakening (n=17). Children coughing soon after awakening were shown to be more severe in their asthma (p<0.001, compared with that of children without cough), and comparing with children coughing thereafter, the cough was significantly related with their occurrence of nocturnal asthma. In contrast, anticholinergic drug was more effective for the late-onset cough, especially for that of 15-30 minutes after awakening. Further, serial measurements of mean heart rate and beat-to-beat variation of the heart rate after awakening in admitted asthmatic children suggested that the cholinergic tone was maximal at around 30 minutes after awakening in these children. Therefore, increased vagal reflex was suggested to play the major role for the cause of such late-onset cough. These results showed the heterogeneity in the mechanism of cough after awakening in asthmatic children.
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  • Kazuko Nakagawa, Yoji Iikura
    Article type: Article
    1988 Volume 37 Issue 10 Pages 1007-1015
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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    In order to assess the data for airway hypersensitivity reaction after an asthmatic episode, ^<81m>Kr inhalation studies by the bolus method and pulmonary function tests were performed on 38 cases of pediatric asthma patients prior to and after exercise. The 38 cases were divided into 3 groups according to the duration of time since their last asthmatic episode: Group I: 16 cases-2 weeks since their last asthmatic episode Group II: 8 cases-4 weeks since their last asthmatic episode Group III: 14 cases-free of an asthmatic episode for one year In the ^<81m>Kr inhalation study, pattern defects were classified into 2 types, Type A and Type B. Type A involves the obstruction of the major airways while Type B indicates early contraction of the airways. Exercise induced changes in Type A pattern defects in ^<81m>Kr ventilatory images in Group I were significantly larger in comparison to Group III. Significant difference between Group II and Group III was observed at 5 minutes after exercise inducement but no significant changes were observed at 15 and 30 minutes. Rapid recovery from exercise induced asthmatic episodes was observed in Group II. These changes were also observed as percent (%) changes in FEV_<1.0>. Hypersensitivity reactions in the major airways were predicted in Group I. Even prior to exercise inducement, early contraction of the airways was detected in 10 cases in Group III.
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  • Hiroyuki Mochizuki, Kenichi Tokuyama, Kimio Tajima, Akihiro Morikawa, ...
    Article type: Article
    1988 Volume 37 Issue 10 Pages 1016-1021
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    We studied bronchial hyperresponsiveness by distilled water inhalation challenge in 23 asthmatic children and 6 age-matched controls, and evaluated the relationships between the threshold of distilled water inhalation challenge and the severity of asthma, the duration of asthma and the serum IgE. The relationships of the threshold of distilled water inhalation challenge to histamine inhalation challenge by the standard method, and to acetic acid inhalation challenge were also examined. The distilled water inhalation challenge showed ood reproducibility, and distilled water seemed to induce only slight bronchoconstriction. There was no significant correlation between the threshold of distilled water inhalation challenge and the duration of asthma and serum IgE, but the correlation with the severity of asthma was significant. Moreover, although no correlation was found between the thresholds of the distilled water and histamine inhalation challenges, the threshold of the former was significantly correlated with that of the acetic acid inhalation challenge (R=0.740, p<0.001). The distilled water inhalation challenge was no simple, effort-independent and unlikely to cause harm that may be used even for children. Moreover, the fact that the results it gave in this study were found to be correlated with those of acetic acid inhalation challenge suggested that distilled water inhalation challenge is a useful technique for the evaluation of bronchial hyperresponsiveness, although it is less sensitive than other inhalation challenges.
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  • Nobuyuki Kobayashi, Takemasa Nakagawa, Hirokazu Okudaira, Koji Ito, Te ...
    Article type: Article
    1988 Volume 37 Issue 10 Pages 1022-1026
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The effects of various nutritional conditions on IgE antibody formation in mice were investigated. Male BALB/c mice maintained on high or low protein diets, or on high or low fat diets, from the age of 4 weeks, were immunized with 1 μg ovalbumin (OA) in aluminium hydroxide (alum). There was no difference in terms of OA-specific IgE response among these 4 groups of mice. IgE and IgG immune responses following immunization with OA were suppressed in C3H/He mice on the low calory diet as compared with the controls, whereas the mice on the high calory diet showed no difference regarding IgE and IgG antibody responses. These results suggest that hypernutrition might not affect IgE antibody formation in mice.
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  • Akira Akasawa, Yasuhei Odajima, Tomomi Kondou, Tosio Katunuma, Syouji ...
    Article type: Article
    1988 Volume 37 Issue 10 Pages 1027-1032
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    To investigate eosinophil function is important in studying the pathophysiology of bronchial asthma. A 19-year-old male, who had been taking steroids for 10 years, had hypereosinophilia during tapering off oral steroids. The number of peripheral eosionphils was over 1.3 × 10^4/cmm, and the peak density was 1.0925 g/ml. The eosinophil in his sputa also saw an increase, and when we investigated on production of superoxide in peripheral granulocytes and granulocytes in sputa, we saw an increase in its production with FMLP stimulus. Furthermore, the IL-1 and IL-2 production rate also increased from peripheral adherent cell. In this study, we saw that eosinophil produces massive amounts of superoxide which may have the possibility of damaging the tissues.
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  • Hitoshi Asamoto, Megumi Kokura, Akira Kawakami, Yoshiyuki Sasaki, Hide ...
    Article type: Article
    1988 Volume 37 Issue 10 Pages 1033-1037
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Theophylline a major drug for bronchial asthma, but effective within a narrow plasma level range of 10-20 μg/ml which is close to the toxic level, and theophylline clearance is affected by various factors such as some drugs. We examined whether azelastine, an antiallergic agent, affects the plasma theophylline level in 10 patients with bronchial asthma. Azelastine was given (4 mg/day in two doses) for at least three days with slow-release Theo-Dur tablets (600 mg theophylline/day in two doses), and the clearance and the plasma concentration of theophylline were compared with those in patients treated with theophylline alone. The theophylline clearance was 2.068 ± 0.6348 in the theophylline alone treated and 1.911 ± 0.4708 in the treated with both revealing no significant difference. After azelastine, the theophylline clearance increased by 20.8% in one and decreased by 25.3% in another, but less than 20% in the other cases. These results suggest that azelastine dose not affects the plasma concentration or the clearance of oral theophylline.
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  • Masaki Fujimura, Tamotsu Matsuda
    Article type: Article
    1988 Volume 37 Issue 10 Pages 1038-1041
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Effect of subthreshold concentration of inhaled STA_2, which is thromboxane A_2 (TXA_2) analogue, on bronchial responsiveness to histamine was investigated in anesthetized and artificially ventilated guinea pigs. Percent increase in pressure at airway opening (Pao) by aerosol histamine (50, 100 μg/ml) was significantly potentiated by subthreshold dose of aerosol STA_2 (0.10 μg/ml) which had previously been determined by dose-response curve of % increase in Pao by inhaled STA_2 (0.033, 0.10, 0.33, 1.0 μg/ml). Repeated inhalation (3 times) of this dose of STA_2 had no effect on Pao as well as saline inhalation. These findings indicate that thromboxane A_2 may contribute to bronchial hyperresponsiveness which is one of the major clinical features of bronchial asthma.
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  • Article type: Appendix
    1988 Volume 37 Issue 10 Pages 1043-1051
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1988 Volume 37 Issue 10 Pages 1052-
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1988 Volume 37 Issue 10 Pages 1053-1056
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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  • Article type: Cover
    1988 Volume 37 Issue 10 Pages Cover5-
    Published: October 30, 1988
    Released on J-STAGE: February 10, 2017
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