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Volume 39, Issue 7
Displaying 1-19 of 19 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 7 Pages Cover30-
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Cover
1990 Volume 39 Issue 7 Pages Cover31-
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 7 Pages App7-
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
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Terufumi ShimodaArticle type: Article
1990 Volume 39 Issue 7 Pages 567-576
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA female hospital pharmacist and a nurse developed occupational asthma due to the inhalation of isonicotinic acid hydrazide(INH)power. The mechanism of sensitization was examined in this study. Furthermore, IgE antibodies specific to INH and isonicotinic acid(INA), the major metabolite of INH, were examined by means of enzyme-linked immunosorbent assay(ELISA). IgE anti-INH antibody activity was detected by ELISA in sera from 5 out of 8 hospital workers who inhaled INH powder during the handilng of INH, and in sera from 10 out of 142 tuberculosis patients receiving oral INH. IgE anti-INA antibody activity was detected in sera 1from 3 of the 8 hospital workers, and from 7 of the 142 tuberculosis patients. Neither IgE anti-INH nor anti-INA antibody activity was detected in sera from 45 patients with asthma or from 42 healthy volunteers. The specificity of the IgE antibodies and the cross-antigenicity between INH and INA were confirmed by ELISA inhibition studies. Our results indicate that sensitization to INH can occur not only by inhalation but also by oral administration, and that the asthmatic symptoms of the patients were caused by an IgE antibody specific to INH as a hapten.View full abstractDownload PDF (1135K) -
Tamotsu Ishizuka, Motohiro KurosawaArticle type: Article
1990 Volume 39 Issue 7 Pages 577-586
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPeptide histidine isoleucine (PHI) as well as vasoactive intestinal peptide (VIP) is considered to be a neurotransmitter of non-adrenergic and non-cholinergic inhibitory nerves in the respiratory tract. We tried to measure PHI immunoreactivity in rat respiratory tracts to evaluate the movement of PHI. A high titer of PHI antiserum which did not react with VIP was obtained from a rabbit immunized with rat PHI, and rat PHI radioimmunoassay was established with this antiserum. Tracheas, extrapulmonary bronchi and lungs were dissected from rats sacrificed by microwave irradiation. They were homogenized with 0.5 N acetic acid and centrifuged at 35,000×g. Lyophilized supernates were used as samples for the redioimmunoassay. PHI immunoreactivity per g wet weight tissue was 5.12 ± 1.35 (mean ± SD) pmol in the tracheas, 1.66 ± 1.15 pmol in the extrapulmonary bronchi and 0.12 ± 0.06 pmol in the lungs. PHI immunoreactivity occurred more in the central airways than in the peripheral ones. VIP immunoreactivity in rat respiratory tracts, assayed simultaneously by radioimmunoassay using commercialized VIP antiserum, was as strong as that of PHI, suggesting that PHI and VIP may be produced from the same precursor at the ratio of 1:1 in rat respiratory tracts.View full abstractDownload PDF (1186K) -
Tsutomu Kimura, Nobuhiro Ishikawa, Kenkichi ShinkaiArticle type: Article
1990 Volume 39 Issue 7 Pages 587-594
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSComparative studies on immunogenicity for compounds (TNBS, CET and 4-AAP) and compound-protein conjugates (TNBS-OA, CET-OA and 4-AAP-OA) were undertaken by the assay systems of humoral reaction (HA) and cellular reaction (DTH)in rabbits. The immunogenicity of TNBS-OA was substantially different from either that of CET-OA or 4-AAP-OA in the assay system of DTH. That is, rabbits immunized with TNBS-OA plus FCA displayed positive DTH reactions to the eliciting antigen (TNBS), while such reactions were never recognized in the rabbits immunized with CET-OA plus FCA or 4-AAP-OA plus FCA to the eliciting antigen of CET or 4-AAP, respectively. The above negative reactions observed in both groups, CET-OA and 4-AAP-OA, can be explained by the ordinary interpretation that the specificity of cellular immunoreaction (DTH) is directed toward the binding part of hapten-protein conjugate. By contrast, TNBS, spread on the skin to evoke DTH, may react with epidermal proteins in vivo to from 2, 4, 6-trinitrophenyl (TNP)-coupled protein. Consequently, it was suggested that this TNP-coupled protein evoked the positive DTH reaction in the TNBS-OA group.View full abstractDownload PDF (925K) -
Kayo Nemoto, Tadao OkamuraArticle type: Article
1990 Volume 39 Issue 7 Pages 595-604
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIntracellular signal transduction during anaphylactic contractions of smooth muscle and the site of signal generation, or antigen-antibody reaction, participating in the appearance of these contractions were studied. The taenia coli was removed from a guinea-pig which had previously been sensitized with anti-egg albumin (EA) rabbit serum or anti-EA rabbit immunoglobulin G (IgG) fraction. Dispersed smooth muscle cells, obtained after enzymatic digestion, were used as the specimen. The dispersed single smooth muscle cells sensitized with anti-EA rabbit IgG fraction showed anaphylactic contractions in response to antigen administration. The method using enzyme-linked antibody revealed binding of IgG by these single muscle cells. Anaphylactic contractions of the single cells were not inhibited by antihistamines or anti-5-hydroxy-trytamine (5HT) agents, but they were suppressed by Y-19,432 {1-butyl-5-hydroxy-2-methyl-N-[1-(2-phenylethyl)-4-piperidyl] indole-3-carboxamide hydrochloride hydrate}, an inhibitor of 5-lipoxygenase. The anaphylactic contractions of the single smooth muscle cells of the guinea-pig taenia coli appear to be initiated in response to IgG binding with the antigen bound to the smooth muscle plasma membrane. For contraction development, the lipoxygenase pathway was shown to participate as a part of the intracellular signal transduction.View full abstractDownload PDF (1489K) -
Ikuo Akutsu, Takeshi Fukuda, Toshio Numao, Sohei MakinoArticle type: Article
1990 Volume 39 Issue 7 Pages 605-609
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe examined the effects of FK-506, a potent immunosupressive agent, on the development of late asthmatic response (LAR) and on the increased bronchial responsiveness to acetylcholine following LAR in guinea pig model of asthma. Guinea pigs sensitized by repeated inhalation of ovalbumin (OA) were intravenously given metopiron 24 hours before and 30 minutes before antigen challenge and to prevent death from immediate severe bronchoconstriction, chlorpheniramine maleate was also injected. When we defined LAR as the responses with a two-fold increase in respiratory resistance during the late phase of antigen challenge, twelve out of fifteen control animals demonstrated apparent LAR. However, when guinea pigs were treated with FK-506 from the beginning of immunization period, the development of LAR was completely inhibited, although similar magnitude of immediate bronchoconstriction was observed, and a subsequent increase in bronchial responsiveness was significantly blocked. We also measured brochial responsiveness to acetylcholine before, 24 and 72 hours after antigen challenge. FK-506-treated aimals inhibited an increase in bronchial responsiveness to acetylcholine. These results suggest that the involvement of cell-mediated immunity may be important in the development of LAR and an increase in bronchial responsiveness.View full abstractDownload PDF (622K) -
Tomoyuki Kabuki, Takeshi Noma, Yutaka Kawano, Masahiko Itou, Izumi Yos ...Article type: Article
1990 Volume 39 Issue 7 Pages 610-614
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effect of Saibokuto on induction of antigen specific IL_2 responsiveness were studied. Saibokuto suppressed the induction of IL_2 responsiveness induced by Dermatophagoides farinae (Df) antigen in peripheral blood mononuclear cells from patients with bronchial asthma. Saibokuto-pretreated adherent cells failed to present Df antigen to non-adherent responding T cells for induction of their IL_2 responsiveness. The same dose of Saibokuto had no impact on non-adherent cells. Saibokuto also suppressed the induced IL_2 responsiveness of lymphocytes from the same patients on stimulation wit PPD, but not with Con A. These combined data suggests that Saibokuto has a weak immunosuppressive effect on Df induced IL_2 responsiveness of lymphocytes from asthmatic children. Effect of Saibokuto on induction of antigen specific IL_2 responsiveness was studied. Saibokuto suppressed the induction of IL_2 responsiveness induced by Dermatophagoides farinae (Df) antigen in peripheral blood mononuclear cells from patients with bronchial asthma. Saibokuto-pretreated adherent cells failed to present Df antigen to non-adherent responding T cell for induction of their IL_2 responsiveness. Non-adherent cells had no impact by the same dose of Saibokuto. Saibokuto also suppressed the induced IL_2 responsiveness of lymphocytes from the same patient on stimulation with PPD, but not Con A. These combined data suggest that Saibokuto has a weak immunosuppressive effect on Df induced IL_2 responsiveness of lymphocytes from asthmatic children.View full abstractDownload PDF (678K) -
Toshio Shimizu, Toshihiko HoriArticle type: Article
1990 Volume 39 Issue 7 Pages 615-620
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe used a questionnaire about Hymenoptra hypersensitivity to investigate 2546 forest administration workers in Nagano prefecture. The results were as follows. 1) Almost all of the workers (96.4%), including 528 (21.5%) hypersensitive workers, had been exposed to insect stings and 34 (1.4%) had lost consciousness as a result (i.e.anaphylactic shock). 2) Many of the workers had been stung by yellow jackets or wasps. 3) Their clinical symptoms were more severe when they were stung on the head or neck. 4) The rate of hypersensitive workers increased with the number of times they had been stung (P<0.05) and tended to increase with age. 5) The rate of atopy was higher among the hypersensitive workers than the non-hypersensitive workers (p<0.01), but those who lost consciousness did not necessarily have a high rate of atopy.View full abstractDownload PDF (720K) -
Harumi Maruo, Keiko Hashimoto, Keiko Shimoda, Kanao Shimanuki, Toru Na ...Article type: Article
1990 Volume 39 Issue 7 Pages 621-630
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA questionnarie on the prognosis of bronchial asthma was sent in 1988 to 1,592 patients (1,038 males, 554 females) averaging 20 years of age after 12 years'follow up. The results were as follows:75.6% in remission, 18.2% improved, 4.0% unchanged, 0.9% worse and 1.3% dead from asthma. The average age of onset was 2.7 years, about 1 year earlier than that in our report of 1965. The average age of remission (growing out of asthma) was 13.0 years for males and 12.3 years for females. The prognosis was significantly poorer among asthmatics with an onset age of under and 2 years, with a 10-year history of asthma before the first visit to our hospital, with severe attack at the initial visit, a history of admissions for the attacks and food allergy. The asthmatic children with food allergy had a 1-year earler onset of attack, a more severe attack at the initial visit, more eczema in infancy, and 2 or more other allergic complications than children without food allergy. We have to closely follow and care for those asthmatic children with high risk factors for an extended period.View full abstractDownload PDF (949K) -
Kazuyoshi Kurashima, Haruhiko Ogawa, Takio Ohka, Masaki Fujimura, Tamo ...Article type: Article
1990 Volume 39 Issue 7 Pages 631-635
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe influence of asthmatic attack on the mucociliary transport system was studied by saccharin test in 8 asthmatic patients. In stable asthmatics, the mean nasal clearance time(NCT)was 44.9±6.1(SE) min, which was greater than in normal controls(15.1±3.4(SE)min), Nasal clearance time in stable asthmatics correlated fairly well with the duration of asthma. There is, however, no relationship between NCT and ages, blood eosinophil counts, blood IgE, or the respiratory functions. Mean NCT during asthmatic attack was 16.9 min, but 1 week later, mean NCT was prolonged to 58.6 min and 101.1 min after 2 weeks. These results indicate that there is mucociliary transport disturbance after asthmatic attack.View full abstractDownload PDF (556K) -
[in Japanese]Article type: Article
1990 Volume 39 Issue 7 Pages 636-638
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 7 Pages 639-
Published: July 30, 1990
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Article type: Appendix
1990 Volume 39 Issue 7 Pages 640-641
Published: July 30, 1990
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Article type: Appendix
1990 Volume 39 Issue 7 Pages 641-
Published: July 30, 1990
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Article type: Appendix
1990 Volume 39 Issue 7 Pages 642-
Published: July 30, 1990
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Article type: Appendix
1990 Volume 39 Issue 7 Pages 643-646
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Cover
1990 Volume 39 Issue 7 Pages Cover32-
Published: July 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (118K)
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