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Volume 39, Issue 8
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 8 Pages Cover33-
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (299K) -
Article type: Cover
1990 Volume 39 Issue 8 Pages Cover34-
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (299K) -
[in Japanese]Article type: Article
1990 Volume 39 Issue 8 Pages 647-653
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (984K) -
Toshio Shimizu, Toshihiko HoriArticle type: Article
1990 Volume 39 Issue 8 Pages 654-661
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe used a questionnaire to investigate Hymenoptera hypersenistivity in 323 forest administration workers and measured total serum IgE and venom sepcific IgE antibodies against yellow jackets and paper wasps. The results were as follows. 1) Most of the workers, including 69 (21.8%) hypersensitive workers, had been exposed to stings by yellow jackets or wasps. 2) The titer of RAST (P<0.05) and RAST positive rate (P<0.01) were higher in the hypersensitive workers than in the non-hypersensitive ones. 3) There was a correlation between venom specific IgE titers to yellow jackets and paper wasps (r_5=0.818). 4) The titer of venom specific IgE increases with the frequency of sting exposure, and decreased gradually with the passage of time. 5) The higher the venom specific IgE titer, the higher the total serum IgE titer. 6) The titer of venom specific IgE, total serum IgE and atopy had no relation to the severity of clinical symptoms.View full abstractDownload PDF (786K) -
Harumi Maruo, Keiko Hashimoto, Keiko Shimoda, Kanao Shimanuki, Toru Na ...Article type: Article
1990 Volume 39 Issue 8 Pages 662-669
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA questionnaire on the prognosis of bronchial asthma was sent in 1988 to 1592 patients (1038 males, 554 females) averaging 20 years of age after 12 years' follow up. We reported on the prognosis and risk factors associated with asthmatic children in part I. The relation between prognosis and other allergic complications, treatment and laboratory data were investigated in this study. Eosinophil counts of more than 1000/mm^3 and/or total serum IgE levels of more than 500 IU/ml (100 IU/ml in infants) indicated poor prognosis. However, the prognosis was not affected either by the allergens themselves or by the number of allergens determined by skin test and RAST. The prognosis was worse for patients with multiple allergic complications than for those without complications. Treatment may after the natural course of childhood asthma, but it has been difficult to evalute the effect of each regimen over a long period. We compared the effect of hyposensitization (specific immunization) and nonbronchodilator antiasthmatic drugs (NBAAD), and found that hyposensitization alone gave better results than NBAAD and its combination. We had better results from hyposensitization over a period of 1 to 5 years than for less than 1 year or more than 5 years. We conclude that asthmatic children with risk factors should be kept under strict environmental control and given suitable therapeutic regiments to avoid the development of allergic diseases, the slow down of "allergic march", and to avoid intractable asthma.View full abstractDownload PDF (866K) -
Yohiko Adachi, Gyokei Murakami, Yuichi Adachi, Masatomo Matsumo, Masak ...Article type: Article
1990 Volume 39 Issue 8 Pages 670-677
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSChironomidea (Insecta) is recently considered one of the most common inhalant antigen in Japan. Intradermal tests with Chironomus plumosus (CP) extract were undertaken on seven hundredand eighteen asthmatic children aged from 6 to 15 years in 10 areas (11 medical institutions) in Japan. The number of cases who showed positive intradermal tears with CP extract was 200 (27.9%) and the positive rate increased in proportion to their age (p<0.005). In each of the 11 medical institutions the positive rates ranged from 12.6% in Akita to 45.5% in Okinawa. There were no significant correlations between the results of the intradermal test with CP and those of RAST, prick test and intradermal test with mite, HD and silk, whereas correlation was noted in the prick test with silk (p<0.01). The CP positive asthmatics had significantly more attacks than the CP negative ones in the summer (p<0.01). The positive rate of asthmatics loving near paddy or farm fields was significantly higher than that of those in urban residential areas (31.3% vs 23.8%, p<0.05). Chironomid midge is one of the most common and important allergen in Japan.View full abstractDownload PDF (1012K) -
Akira Kawasaki, Kiyoshi Hoshino, Yutaka Mizushima, Saburo YanoArticle type: Article
1990 Volume 39 Issue 8 Pages 678-683
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to determine which factors world affect the improvement of bronchial hypersensitivity in asthmatic patients, a clinical investigation was performed on 42 cases whose bronchial hypersensitivity had been tested more than two times. The following results were obtained. 1) The numbers of bronchial hypersensitivity-improved cases was 16 while there were 26 unimproved cases. There was no statistical difference in age, sex, type of asthma, severity of disease at first visit or type of therapy between the two groups. FEV_<1.0>% in the bronchial hypersensitivity-improved group was significantly higher than that in the unimproved group (p<0.01). 2) In the improved group, all cases (16/26) were shown to have become free of symptoms, but this applied to only 38% (10/16) in the unimproved group. 3) In the 26 cases who had become free of symptoms, the improvement index in histamine test and the ratio of improved cases showed a tendency to increase as the period during which the patient showed no symptoms extended. It was suggested that bronchial hypersensitivity in cases with higher FEV_<1.0>% would improve more easily, and that the induction and maintanance of a symptom free state is important for the improvement of bronchial hypersensitivity.View full abstractDownload PDF (619K) -
Reiko KishikawaArticle type: Article
1990 Volume 39 Issue 8 Pages 684-695
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the relation between the incidence of pollinosis and pollen counts in Fukuoka City From 1983 to 1989 to clarity the "cause and effect" relationship and to evaluate the severity of pollinosis in this district. We collected questionnaries on pollinosis from six otorhinolaryngology clinics in our city during the pollination seasons from 1983 to 1989. Cryptomeria j., Cupressaceae and Gramineae pollens, which were sampled with Durham's samples from January to June, were sent from seven sampling locations in our city. The number of pollens was counted in our hospital. The total number of patients with pollinosis over the seven years was 4193. Females were numerous than males by one and a half times. The age group with the highest incidence was the thirties (41.9%), followed by the twenties (19.8%) and forties (18.4%). The incidence of Japanese cedar pollinosis was 92.6 percent and grass pollinosis 30.3 percent of all the patients because 23.0% of them overlapped. We found that the severity of nose and eye complaints and other symptoms of pollinosis in our study was milder than that in Tokyo and other Kanto districts. Annual changes in total pollen counts were remarkable, and a high incidence of Japanese cedar pollinosis was found as total pollen counts of Cryptomeria j. and Cupressaceae increased in Fukuoka City.View full abstractDownload PDF (1330K) -
Yukio Matsumura, Mariko Shiga, Keiko Setoyama, Yuko Tomoe, Hiromi Otsu ...Article type: Article
1990 Volume 39 Issue 8 Pages 696-700
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSCommercially available antibotics for injection are supplied with test ampules. Users are instructed to dissolve them to make 300μg/ml solution for intradermal pretests to avoid allergic reactions. Sometimes this concentration is too low to prevent anaphylactic reactions. In the present study, we tried to find the maximum concentration for the intradermal tests which would have high sensitivity without giving nonspecific, false positive reactions. We investigated intradermal tests with cephalothin (CET) in a patient who suffered from anaphylaxis after drip infusion with CET, although she was judged to be CET by the usual intradermal test prior to the infusion. Her CET skin test was negative at a concentration of 150 μg/ml and positive at 300 μg/ml 6 weeks after anaphylaxis, but nagative at 300 μg/ml and positive at 1000 μg/ml 4 and 7 years after anaphylaxis. Prick tests were always nagative, even with the maximum soluble concentration of CET, 200 mg/ml. Nonspecific reaction to intradermal tests at concentrations as high as 1000 μg/ml were examined with 20 kinds of penicillins and cephems in 51 healthy subjects without histories of drug allergies. Very few false positive reactions were observed, except in 5 out of 24 cases with cefotiam. Intradermal tests at 3000 μg/ml, however, frequently resulted in nonspesific reactions. We conclude that 1000 μg/ml, not 300 μg/ml solutions should be used for intradermal tests to prevent allergic reactions to the injection of antibiotics.View full abstractDownload PDF (600K) -
Shuji Ohno, Teruhiko Suzuki, Kiyoshi Hara, Fumihiko Imai, Masahiko Tan ...Article type: Article
1990 Volume 39 Issue 8 Pages 701-707
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 68-year old man with suspected allergic granulomatiosis and angiitis is reportes. He had teceived 10 mg of prednisolone daily since July 1998 for asthma. He abruptoy developed muscle wealness of the lower extremities, followed two days later by paraplegia. Six days after the onset of the muscle weakness, he was hospitalized. He showed disturbance of recent memory, disorientation, neck rigidity, paraplegia, mild muscle fasciculation and hypesthesia. He also showed paralytic ileus. Laboratory findings showed leukocytosis (24580/mm^3), eosinophilia (56% of the peripheral white blood cells and 19% of the cells in the cerebrospinal fluid), on erythrocyte sedimentation rate of 31 mm/h, and the IgE level of 1200IU/ml. The ECG showed loss of the r-wave in V_1 and V_2 A granulomatous lesion anterior to the spinal cord was found on myelography and MRI. Prednisolone was given at a dose of 60 mg daily with resulting in the improvement of the clinical symptoms and eosinophilia. There was disappearance of the granuloma on MRI performed after prednisolone therapy. Despite the severe maniestation of allergic granulomatosis and angiitis, prednisolone therapy had a marked effect in this patient. The granulomatous lesion anterior to the spinal cord shown by MRI suggested an eosinophilic granuloma, and may have been the etiology of some of the neurologocal symptoms.View full abstractDownload PDF (1179K) -
Yuji AkiyamaArticle type: Article
1990 Volume 39 Issue 8 Pages 708-713
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of IL-1 and GM-CSF on accessory function of macrophages and dendritic cells (DC) in Con A-induced T cell responses were investigated. The accessory cells were separated from adherent cells of human peripheral mononuclear cells. The accessory function of DC was found to be stronger than that of macrophages. IL-1 and GM-CSF significantly enhanced the T cell responses by augmenting the accessory function of DC in a dose-dependent manner (p<0.01), whereas these monokines produced no augmentative effects on macrophages, nor facilitated T cell responses without DC.View full abstractDownload PDF (715K) -
Hideki Teshima, Hiromi Kihara, Tetsuya Nakagawa, Yoshiaki HoriArticle type: Article
1990 Volume 39 Issue 8 Pages 714-717
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAlthough alopecia universalis is an incurable disease, we have obtained favorable results using a low dose of 2.5 mg/kg of cyclosporine A and 5 mg/day of prednisolone without adverse effects. We report our clinical experience of the treatment of two cases of alopecia universalis. Immunological examinations showed marked changes in the ratio of cell subsets in peripheral blood. There was an increase of OKT8 positive cells and NK cells, reduction of IL-2R positive cells. There immunological changes following recovery from alopecia suggest a correlation between immunological disorders and the pathogenesis of this disease (alopecia universalis).View full abstractDownload PDF (553K) -
Article type: Appendix
1990 Volume 39 Issue 8 Pages 719-729
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (580K) -
Article type: Appendix
1990 Volume 39 Issue 8 Pages 730-732
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (254K) -
Article type: Cover
1990 Volume 39 Issue 8 Pages Cover35-
Published: August 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (223K)
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