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Volume 41, Issue 7
Displaying 1-24 of 24 articles from this issue
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Article type: Cover
1992 Volume 41 Issue 7 Pages Cover30-
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Cover
1992 Volume 41 Issue 7 Pages Cover31-
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1992 Volume 41 Issue 7 Pages 713-719
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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Takashi Watanabe, Hidemi Tomonaga, Masahito Inuyama, Naoki Miura, Teru ...Article type: Article
1992 Volume 41 Issue 7 Pages 720-726
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAsthmatic symptoms are worsened after drinking small amounts of alcoholic beverages in Japanese asthmatic patients. Our previous results showed that the ingestion of pure ethanol caused a fall in FEV_<1.0> in about half of the Japanese asthmatics we studied. We studied the inhibitory effects of pretreatment with three kinds of anti-asthmatic agents on ethanol-induced bronchoconstriction in six Japanese asthmatic patients. We tested oral cyproheptadine hydrochloride (8 mg), which is an anti histamine agent, inhaled disodium cromoglycate (2 mg), which has an inhibitory effect on the release of chemical mediators from mast cells, and inhaled atropine sulfate (3 mg), which is an anti-cholinergic agent. Pretreatment with cyproheptadine significantly inhibited the fall in FEV_<1.0> 120 minutes after ethanol challenge (p<0.05). Inhaled DSCG had significant inhibitory effects on the fall in FEV_<1.0> 15 and 30 minutes after ethanol challenge (p<0.05). Inhaled atropine had no inhibitory effect. These results suggest that histamine, released from mast cells, plays an important role in ethanol induced bronchoconstriction in Japanese asthmatic patients.View full abstractDownload PDF (688K) -
Kazuo Akiyama, Riichirou Mikami, Junzaburou Kabe, Yousuke Egashira, Ta ...Article type: Article
1992 Volume 41 Issue 7 Pages 727-738
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe first nationwide research into adult bronchial asthma in Japan proposed a new classification of adult asthma. Adult asthma was categorized into child onset asthma, adult onset asthma and adult relapse asthma. The frequency of child onset asthma, adult onset asthma and adult relapse asthma in adult asthma was 11.2%, 77.3% and 3.7%, respectively. The frequency of child onset asthma decreased markedly in the older age group. On the other hand, the frequency of adult onset asthma increased, and reached more than 90%, in the older age group. The frequency of the following factors: atopic asthma, complications with other atopic diseases, mild asthma, male patients, experience of mechanical ventilation, visits to night clinics and oxygen therapy on acute attack, was significantly higher in the child onset asthma group than in the adult onset asthma group. The frequency of infectious type, aspirin intorerance, steroid dependent asthma, severe asthma and regular medication was significantly higher in the adult onset asthma group. Adult relapse asthma seemed to fall between these two groups. Based on the above observations, we proposed a new classification of adult asthma which includes child onset asthma, adult onset asthma and adult relapse asthma.View full abstractDownload PDF (1438K) -
Arihiko Kanehiro, Kiyoshi Takahashi, Shinya Tada, Ryo Soda, Atsuhiro I ...Article type: Article
1992 Volume 41 Issue 7 Pages 739-748
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSLate asthmatic response (LAR) as well as delayed asthmatic response (DeAR) is an important clinical characteristic in adult severe asthma. These responses might be based on cell to cell interaction following lymphocyte activation. Therefore, to clarify the pathogenesis of LAR, we studied the lymphocyte functions of adult asthmatics with LAR provoked by inhalation of house dust and Candida antigen. The results revealed that mite antigen-specific lymphocyte blastogenesis, IL-2 and ECF production were significantly higher in asthmatics with LAR provoked by house dust antigen than in normal subjects and asthmatics with LAR by house dust and LAR by Candida, though there was no significant difference in NCF. Candida antigen-specific lymphocyte blastogenesis, IL-2, ECF and NCF production were significantly higher in asthmatics with LAR provoked by Candida antigen than in normal subjects and asthmatics with IAR or LAR provoked by house dust. There was a positive correlation between Candida antigen-specific IL-2 and NCF production in asthmatics with LAR provoked by Candida antigen. These results sugest that antigen-specific lymphocyte activation may play an important role in the pathogenesis of LAR, especially in asthmatics with LAR provoked by Candida antigen, and that LAR and DeAR should be considered inclusively as cell-mediated allergy.View full abstractDownload PDF (1018K) -
Kiri Honma, Yoichi Kohno, Kiyomi Hirano, Naoki Shimojo, Hiroshi Suzuki ...Article type: Article
1992 Volume 41 Issue 7 Pages 749-756
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe performed rectal and/or oral challenge tests on 8 patients with suspected but unproven diagnosis of food allergy based on detailed medical history and findings from radioallergosorbent tests (RAST). The cells appearing in the rectal mucosal smear serially for 48 hours after allergen challenge were examined. The following results were obtained: 1) Significant numbers of not only eosinophils but also mast cells appeared in the rectal smears after challenges with suspected-food allergens, but not with unrelated foods. This confirmed the antigen-specificity of the method. 2) In some cases, the appearance of mast cells and eosinophils was bimodal, suggesting the existence of a later allergic response in addition to an immediate-type reaction. 3) The food-specific appearance of mast cells and eosinophils was observed in association with clinical symptoms after challenge, even in patients whose IgE antibodies to the allergen were negative or commercially unavailable. In conclusion, we propose that rectal mucosal cytology in conjunction with rectal and/or oral challenge tests is a reliable and objective method to diagnose unproven or suspected food allergy.View full abstractDownload PDF (934K) -
Takao Suganuma, Yasuo Kawakami, Mitsuru Adachi, Terumi Takahashi, Mino ...Article type: Article
1992 Volume 41 Issue 7 Pages 757-765
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo determine whether Oriton IgE kit, a new kit for the measurement of allergen-specific IgE antibodies, is useful in secreening allergen-specific antibody, we measured the titers of IgE antibodies against 11 different allergens (house dust 2, Dermatophagoides farinae, Japanese cedar, ragweed pollen, egg white, milk, cat epithelium, dog epithelium, Candida, Alternaria and Aspergillus) with the Oriton IgE kit, and the results were compared to those of intradermal tests and RAST in 103 allergic patients and 10 normal subjects. There was a clear correlation between IgE antibody titers measured by the Oriton IgE kit and the RAST. The correlation coefficient was 0.76 (p<0.01) and the total correspondence rate was 85.9%. We also found strong correlation between the Oriton IgE kit and RAST in IgE antibody titer against 5 different allergens, Dermatophagoides farinae, Japanese cedar, ragweed pollen, egg white and Candida. The correlation coefficient was over 0.70. The correspondence rate, sensitivity and specificity of the Oriton IgE kit to intradermal tests was 71.8%, 45.3% and 87.8% respectively. The sensitivity of the Oriton IgE kit was slightly higher, while the specificity was slightly higher in RAST, although the differences were not statistically significant between these methods. Correspondence rate of the Oriton IgE kit was similar to that of RAST. These results suggested that the Oriton IgE kit is useful in screening allergen specific IgE antibodies.View full abstractDownload PDF (866K) -
Tadayoshi Kosugi, Shigeru Saitoh, Noboru Tamaki, Katsuyoshi Shimoji, T ...Article type: Article
1992 Volume 41 Issue 7 Pages 766-771
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe determined, using the MAST system, specific IgE antibodies to allergens in the circulating blood of 127 patients with bronchial asthma, allergic rhinitis and atopic dermatitis in Okinawa. The positive rates to inhalant allergens in all patients examined by the MAST system were as follows: Dermatophagoides farinae 65%, house dust 58%, cat epithelium 17% and Japanese cedar 9%. In addition, the positive rates to food allergens found in all patients were as follows: wheat 16%, shrimp 14%, egg white, rice and crab 12%. The average number of positive allergens in the patients with atopic dermatitis was larger than that in those with allergic respiratory diseases only. The above five specific IgE antibodies were detected simultaneously in 12 (9%) of the 127 patients. In addition, the average number of overlapping positive allergens was 2.0 in all patients. From these results, it was suggested that the number of overlapping positive allergens in patients on Okinawa is smaller than in other areas of Japan as compared with other papers.View full abstractDownload PDF (610K) -
Komei Ito, Satoshi Kikuchi, Masanori Yamada, Shinpei Torii, Masami Yos ...Article type: Article
1992 Volume 41 Issue 7 Pages 772-777
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe drug concentrations in nebulizers and nebulized solutions generated by the ultrasonic nebulizer OMRON NE-U10B and the jet nebulizer INSPIRON NEBULIZER 002305 were examined. With the ultrasonic nebulizer, increases in the concentrations of saline, DSCG and isoproterenol in the nebulizer were observed; the concentrations of those in the nebulized solutions also increased. The increase was most dramatic just before the solution was emptied. No degradations of DSCG or isoproterenol were detected in the nebulized solutions, indicating that these drugs are stable against ultrasonic nebulization. An increase in the drug concentrations in the jet nebulizer was also observed. The concentrations of the nebulized solutions also increased, but the concentrations in the nebulized solution were lower than those in the nebulizer at any time. On inhalation therapy, it is important to give consideration to these concentration changes. The nebulizer should not, for example, be refilled with a new drug solution.View full abstractDownload PDF (607K) -
Ikuo Akutsu, Takeshi Fukuda, Sohei MakinoArticle type: Article
1992 Volume 41 Issue 7 Pages 778-786
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have previously reported that the 5-day culture supernatants of peripheral blood mononuclear cells (PBMC) from Dermatophagides farinae (DF) sensitive asthmatics stimulated with 10 ng/ml DF antigen contain eosinophil chemotactic activity (ECA) with an apparent molecular weight >30000 Da. In the present study, we examined the effects of CyA and FK on the ECA. ECA was tested using modified Boyden chamber method. We found that when CyA or FK was added to the culture throughout the experiment, the production of the factors with ECA by PBMC was inhibited in a dose-dependent manner. These inhibitory effects were unchanged by the addition of a sufficient dose of IL-2 to the culture medium. Isoelectrofocusing of the PBMC culture supernatants consistently yielded a major ECF activity at pH 7.0-7.5. The addition of CyA inhibited this major peak. In conclusion, these results suggest that mononuclear cells stimulated with related antigen produce substances which possess ECA and that CyA and FK can block the production of this substance. Therefore, there is a possibility that an immunosuppressive agent may be useful in bronchial asthma therapy by inhibiting the migration of eosinophils.View full abstractDownload PDF (945K) -
EFFECT OF A LEUKOTRIENE B_4 ANTAGONIST ON SUBSTANCE P-INDUCED GRANULOCYTE INFILTRATION IN MOUSE SKINSanae Tomoe, Itsuo Iwamoto, Hisao Tomioka, Sho YoshidaArticle type: Article
1992 Volume 41 Issue 7 Pages 787-791
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSubstance P causes granulocyte (neutrophil and eosinophil) infiltration in mouse skin by inducing mast cell degranulation. However, the mediator responsible for this granulocyte infiltration has not been determined. In this study, we examined the effect of a leukotriene B_4 (LTB_4) antagonist ONO-4057 on substance P-induced granulocyte infiltration in the skin of BALB/c mice. Pretreatment with the LTB_4 antagonist decreased substance P-induced neutrophil and eosinophil infiltrations in mouse skin at 6 h to the same extent that an inhibitor of mast cell degranulation disodium cromoglycate decreased those responses. The LTB_4 antagonist also decreased substance P-induced neutrophil, but not eosinophil, infiltration in mouse skin at 24 h. We conclude that LTB_4 is a major mast cell-derived chemotactic mediator for initiating substance P-induced neutrophil and eosinophil infiltrations in mouse skin.View full abstractDownload PDF (533K) -
Article type: Appendix
1992 Volume 41 Issue 7 Pages 792-795
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 796-802
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 803-804
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 805-
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 806-
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 807-812
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 813-
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 814-815
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 816-
Published: July 30, 1992
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 816-
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 7 Pages 817-820
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Cover
1992 Volume 41 Issue 7 Pages Cover32-
Published: July 30, 1992
Released on J-STAGE: February 10, 2017
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