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Volume 43, Issue 2-1
Displaying 1-18 of 18 articles from this issue
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Article type: Cover
1994 Volume 43 Issue 2-1 Pages Cover13-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
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Article type: Cover
1994 Volume 43 Issue 2-1 Pages Cover14-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1994 Volume 43 Issue 2-1 Pages App4-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1994 Volume 43 Issue 2-1 Pages 87-96
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
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Yuichi Takahashi, Hiroshi Miyazawa, Masahiro Sakaguchi, Sakae Inouye, ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 97-100
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the relationship between the amounts of Cry j I in house dust and airborne Cryptomeria japonica pollen in the same location. Cry j I was still detected in house dust collected two weeks after airborne C.japonica pollen had disappeared. Disappearance of Cry j I in house dust coincided with the disappearance of symptoms in the C.japonica pollinosis patients who lived in the same area. Airborne Cupressaceae pollen appeared during the latter half of the C.japonica pollen season. Disappearance of Cupressaceae pollen did not coincided with the disappearance of the symptoms in C.japonica pollinosis patients. Therefore, some symptoms of C.japonica pollinosis patients after C.japonica pollen disappeared from the air may be caused by pollen which had attached to clothes and been brought indoors.View full abstractDownload PDF (360K) -
Kotaro Ukai, Ryo Amesara, Sawako Masuda, Setsuo Nakamoto, Chikahisa Oh ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 101-105
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe evaluated the clinical and pathophysiological efficacy of hyposensitization with Japanese sugi pollen extracts to sugi pollinosis. Twenty patients with Japanese cedar pollinosis received hyposensitization with Japanese cedar pollen extracts for one to 15 years with a mean of 9.5 years were compared with 18 patients without hyposensitization. The improvement of nasal symptoms was not found in patients with hyposensitization of sugi pollen extracts compared with patients with non-hyposensitization, but the number of mast cells in nasal scraping, nasal hypersensitivity to histamine, and specific sugi IgG4 antibody in serum was improved significantly compared with non-hyposensitization group. These findings suggest that the continuation of hyposensitization with sugi pollen extracts is recommendable as a basic treatment against seasonal nasal allergy.View full abstractDownload PDF (522K) -
Tadao Enomoto, Shigeo OhnishiArticle type: Article
1994 Volume 43 Issue 2-1 Pages 106-112
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA basc and clinical study was carried out to evaluate the usefulness of the Shionoria Specific IgE (SIST) kit for false cypress allergen. The test materials were sera from 152 patients who visited our clinic with symptoms of nasal allergy during the period when Japanese cedar and false cypress pollens are prevalent in the air. The standard curve drawn on the standard serum, which was part of the test kit, was linear. Dilution, inhibition and absorption tests were all satisfactory. Reproducibility studies, different-day, and inter-performers, were all excellent. Non-allergic sera and umbilical cord sera showed less reactivity than the reference serum which is classified as class 0. The sensitivity of the SIST kit for False cypress was 89.9%; specificity 86.3%, and concorance rate 88.2%. The SIST test results for the sera well correlated with the results given by skin tests. These results are good evidence of the excellence of this kit. It was of interest that in the inhibition test, some false cypress positive sera were blocked with Japanese cedar extract as well as with false cypress extract, while other false cypress positive sera were blocked only with false cypress extract. Similar results were obtained in the absorption test. This suggests that the antibodies of some patients recognize a portion of the false cypress allergen which is common to a particular portion of the Japanese cedar allergen.View full abstractDownload PDF (602K) -
Tsuyoshi Toba, Tomomichi Kurosaki, Fumio Ohta, Kazuto Tamai, Hiroshi I ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 113-119
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSElevated serum levels of theophylline, a first-line antiasthma drug, are sometimes associated with febrile respiratory infection (FRI). Although it seems to be wellknown, conflicting reports still appear in journals. We studied retrospectively theophylline clearance (th-cl) in 74 episodes of acute asthma (44 with and 30 without FRI, in patients aged 12-mos.〜13-yrs.) and tried to reveal the effect of fever or pathogens on th-cl. Th-cl was estimated by a single sample technique during intravenous drip infusion of aminophylline. The results were as follows: 1) Forty four episodes with FRI included 20 viral, 10 bacterial and 2 Mycoplasma pneumoniae infections (Table 2). 2) Th-cl in 44 episodes with FRI was significantly lower than in 30 without FRI (p<0.001). 3) Decreased tendency of th-cl in episodes with viral infection was observed, but statistically it was not significant (p<0.1). However, the differences of th-cl among 9 pair-cases with and without viral infection were quite clear (p<0.01). 4) Th-cl in episodes with 10 bacterial and 2 Mycoplasma infections was reduced significantly (p<0.01). 5) There was no difference in th-cl between episodes with viral, and bacterial or Mycoplasma infections (p<0.1). As a result, it is suggested that fever, regardless of its origin, may decrease th-cl in acute asthma with FRI.View full abstractDownload PDF (713K) -
Yuji Maeda, Hiroshi Yasueda, Kazuo Akiyama, Takao Shida, Terumasa Miya ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 120-126
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the efficacy of a special cloth encasing (Microguard) in protecting against house dust mite exposure. We vacuumed dust from right or left half surface of a shiki-futon (Japanese style mattress). Then we encased the shiki-futon by a new special encasing, vacuumed dust from the other part of the shiki-futon and got a pair of dust samples. We had done the same of the same shiki-futon by a used special encasing (used for one and half years) for about 2 weeks later. We prepared 7 shiki-futons and collected 14 pair dust samples. We weighed the dust and measured the mite allergens with a monoclonal antibody to Dermatophagoides pteronissynus and Dermatophagoides farinae. The dust level was 1.0% of the control (no encasing) in the new encasing group and 2.0% of the control in the used encasing group. The Der I concentration was 2.5 μg/(g dust) in the new encasing group and 3.2 μg/(g dust) in the used encasing group. The Der II concentration was 1.6 μg/(g dust). The total amount of Der I was 0.1% of the control in the new encasing group and 0.5% of the control in the used encasing group. The total amount of Der II was 0.2% of the control in the new encasing group and 0.7% of the control in the used encasing group. We compared Der p and Der f levels in the dust samples which we assayed and found no significant differences either in Der I or in Der II allergen. We concluded that Microguard was a useful tool to avoid mite allergen exposure by reducing not only the concentration of mite allergens but also the amount of dust.View full abstractDownload PDF (658K) -
Rokuo Oosaki, Yutaka Mizushima, Akira Kawasaki, Masashi Kobayashi, Har ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 127-133
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe undertook fundamental studies on the measurement of urinary leukotriene E_4, a stable end-product of peptidoleukotrienes, and obtained the following results. 1) After addition of ^3H-LTE_4 to 2 ml of urine, LTE_4 was extracted with a commercial C18 mini-column, and purified by high performance liquid chromatography and then LTE_4 in the elute was measured with an enzyme immunoassay kit. 2) As total recovery of LTE_4 was 35.3±0.9% (n=76), the amount of LTE_4 was calculated after correction of the recovery with ^3H-LTE_4. 3) Before extraction of LTE_4 by C18 column, the column was washed by ethyl acetate to remove interfering substances. This procedure greatly facilitated the following high performance liquid chromatographic analysis. 4) The basal levels of urinary LTE_4 of seven aspirin-sensitive asthmatics were elevated as compared with five asthmatics without aspirin sensitivity (358.9±114.0 versus 77.9±47.3 pg/mg・cr; p<0.05). 5) In two asthmatic patients, improvement of their symptoms was accompanied with decrease in the LTE_4 level in urine. This method enabled us to measure LTE_4 concentrations in a small volume of urine (2 ml), and would be useful for evaluating the pathogenesis of bronchial asthma.View full abstractDownload PDF (689K) -
Yasuko Ikeda, Sohei MakinoArticle type: Article
1994 Volume 43 Issue 2-1 Pages 134-141
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe measured the total IgE in sera from normal and allergic subjects by using the "Magic Lite^<(R)> Total IgE High Sensitivity" chemiluminescent immunoassay kit. The accuracy precision and correlation with RIST of this kit were sufficient to use it for clinical diagnosis. The analytical sensitivity was 0.075 IU/ml, and this kit was sensitive enough to measure total IgE in cord blood. The mean and SD of total IgE measured in the sera of 115 cases of the normal subjects was 72.3±83.7IU/ml, and the 95% confidence level of those values was 280IU/ml. Thus the cut off value of the total IgE appeared to be 250〜300IU/ml. The total IgE values measured in the sera of the bronchial asthma group and the allergic rhinitis group were significantly higher than those of the normal subjects. RAST scores to house dust and house dust mites correlated with the total IgE values in the sera. The values of total IgE measured in the cord blood group ranged from 0.075IU/ml (limit of the sensitivity) to 10.09IU/ml, and the geometric mean was 0.295IU/ml. Ten % of the cord blood samples showed IgE values of more than 1IU/ml. As a method of measuring total IgE in cord blood, this kit would appear, from our results, to be useful for the detection of atopic factors in the early stages of life.View full abstractDownload PDF (675K) -
Hiroshi Fujimiya, Shigeru Nakashima, Takahiko Kumada, Yoshikatsu Nakam ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 142-151
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAn antiallergic drug, pemirolast potassium (TBX) at concentrations between 0.01 and 10μg/ml inhibited antigen (Ag)-stimulated degranulation in RBL-2H3 cells, which have the properties of mucosal mast cells. At the same concentrations, the drug suppressed both the formation of inositol 1, 4, 5-trisphosphate and the mobilization of Ca^<2+>, indicating the prevention of phospholipase C activation. The production of 1, 2-diacylglycerol and phosphatidic acid, which was mainly due to phosphatidylcholine hydrolysis, was also suppressed. Moreover, TBX reduced Ag-induced liberation of arachidonic acid, a precursor of eicosanoids, implying the inhibition of phospholipase A_2. These data suggest that TBX inhibits the activation of phospholipase C, leading to decreased formation of the signal transducing molecules necessary for cell activation.View full abstractDownload PDF (1066K) -
Akira Hoshioka, Yoichi Kohno, Toshiyuki Katsuki, Naoki Shimojo, Shigek ...Article type: Article
1994 Volume 43 Issue 2-1 Pages 152-158
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThere is evidence from animal models that the iodine content of thyroglobulin (Tg) may influence its antigenicity in thyroid autoimmunity. To elucidate the effect of iodination of hormonogenic sites of human Tg (hTg) on its autoantigenicity, a synthetic peptide (TB:hTg 2546-2571), containing two hormonogenic tyrosine residues of hTg, and a chemically-iodinated peptide (TB-I) were prepared. We immunized C3/He(H-2^k) mice, a high responder strain to Tg, and BALB/c(H-2^d), a low responder strain, with TB or TB-I plus lipopolysaccharide. Lymph node cells from the two strains immunized with TB or TB-I proliferated in response to both TB and TB-I. Anti-Tg autoantibodies were detected in both strains when immunized with TB-I, while immunization with TB failed to produce anti-Tg antibodies. Furthermore, one of the C3/He mice immunized with TB-I developed diffuse thyroiditis, but BALB/c mice did not. These findings indicate that the iodination of the hormonogenic tyrosine residues of hTg, in other words, the synthesis of mono- and di-iodotyrosine (MIT and DIT) residues, is necessary for the production of anti-Tg autoantibodies in high and low responder mice and for the induction of autoimmune thyroiditis in high responder mice.View full abstractDownload PDF (812K) -
Article type: Appendix
1994 Volume 43 Issue 2-1 Pages 159-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1994 Volume 43 Issue 2-1 Pages 159-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Appendix
1994 Volume 43 Issue 2-1 Pages 159-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Appendix
1994 Volume 43 Issue 2-1 Pages 160-163
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
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Article type: Cover
1994 Volume 43 Issue 2-1 Pages Cover15-
Published: February 28, 1994
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (116K)
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