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Volume 47, Issue 1
Displaying 1-18 of 18 articles from this issue
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Article type: Cover
1998 Volume 47 Issue 1 Pages Cover1-
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Cover
1998 Volume 47 Issue 1 Pages Cover2-
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Katsutoshi TerasawaArticle type: Article
1998 Volume 47 Issue 1 Pages 1-5
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Sho MatsusitaArticle type: Article
1998 Volume 47 Issue 1 Pages 6-10
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Shigekatsu KohnoArticle type: Article
1998 Volume 47 Issue 1 Pages 11-18
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Fumiyoshi Ojima, Tohru Shoji, Yoshito NakagawaArticle type: Article
1998 Volume 47 Issue 1 Pages 19-25
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to investigate the dispersion pattern and compare the effect of spacer devices (Volumatic, Volumatic Soft and InspirEase), the Becotide^【〇!R】 100 inhaler actuating 100 μg of beclomethasone dipropionate (BDP) per shot was studied with respect to its distribution ratio in a twin impinger and also compared with that of the Becotide^【〇!R】 50 inhaler. The distribution patterns of BDP during each stage of the twin impinger were not affected by the puff times of the Becotide^【〇!R】 100 inhaler. No significant difference was observed when the distribution ratios between the Becotide^【〇!R】 50 inhaler and Becotide^【〇!R】 100 inhaler were compared. All of these three spacer devices reduced the deposition ratio in stage I which is assumed to be the oral cavity and oropharynx. As the puff times of the Becotide^【〇!R】 100 inhaler increased. the BDP deposited in the spacer increased and that of stage II assumed to be the lung decreased. These results suggested that the inhalation volume of BDP would depend on the puff times during clinical use and the inhalation volume of BDP for the Becotide^【〇!R】 100 inhaler would be double that of the Becotid^【〇!R】 50 inhaler. The spacer devices could decrease the local adverse effects caused by deposited BDP in the oral cavity. When using large spacer devices, one ro two puff times into the spacer would be recommended for the best clinical effectiveness. The Volumatic could be expected to produce a superior BDP inhalation volume by reducing the deposition in the oral cavity in the 3 spacer devices examined in this study.View full abstractDownload PDF (795K) -
Yuriko Takahashi, Sei-ichi Ichikawa, Yukoh Aihara, Shumpei YokotaArticle type: Article
1998 Volume 47 Issue 1 Pages 26-33
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSHypersensitivity to buckwheat allergen frequently causes anaphylactic type reactions including urticaria, wheezing, dyspnea and/or shock. Though the susceptible pupil would be recommended to be careful for school lunch and picnic meals, the prevalence of buckwheat allergy in school children has not yet been elucidated. In this study, data on the children allergic to buckwheat were collected by sending questionnaire to 341 nurses in elementary school in Yokohama. Among the total subjects of this investigation, 92, 680 childrn, the incidence of buckwheat allergy was determined 0.22% (140 boys and 54 girls). This percentage was not so low level besides the prevalence of such allergic diseases as bronchial asthma. atopic dermatitis, allergic rhinitis, allergic conjunctivitis and food allergy was 5.6%, 4.2%, 3.1%, 1.6%, and 1.3%, respectively. Although a large majority of clinical symptoms of buckwheat allergy were urticaria (37.3%), skin itching (33.3%), and wheezing (26.5%). Four children (3.9%) experienced anaphylactic shock having a need of medical emergency treatment. The incidence of anaphylactic shock due to buckwheat was higher than those due to egg and milk allergy. Actually 7 pupil was provoked allergic reaction by buckwheat noodle served at school lunch, and I pupil at picnic meals. Thus, school children allergic to buckwheat is not rare, and it is important to withdraw buckwheat food from school lunch and picnic meals.View full abstractDownload PDF (827K) -
Yasuo To, Takeshi Koshino, Masako Kubo, Hiroyasu Muramatsu, Koichiro K ...Article type: Article
1998 Volume 47 Issue 1 Pages 34-40
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 29-year-old woman of the bronchial asthma was admitted to our hospital. Her asthmatic symptoms were refractory in spite of the administration of 30 mg of daily-oral prednisolone. During the asthma-attack, marked arterial oxygen desaturation was noted. So we doubted that she had obstructive sleep apnea complicated with obesity. Sleep Apnea Monitor revealed her nocturnal desaturation and frequent sleep apnea. To avoid the desaturation, we recommended her to keep prone position during the sleep. And both desaturation and asthmatic symptoms were dramatically improved. Nasal-CPAP also had been effective for them. These findings suggest that sleep apnea mediated oxygen desaturation may be one of the promotor of asthmatic symptoms.View full abstractDownload PDF (533K) -
Tsugio Nakazawa, Yoshikazu Kawakami, Morio Sudo, Setsuo Kobayashi, Sus ...Article type: Article
1998 Volume 47 Issue 1 Pages 41-47
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe Japan Asthma Death Investigation Committee sent questionnaires to hospitals with more than 100 beds, and studied the clinical characteristics of 313 reported cases who died of asthma between 1992 and 1994. Forty percent of them were at the age between 60 and 79. Deaths of young adults in the twenties tended to increase. One third of the deaths was due to asphyxia. More than half of the patients were classified infectious or mixed type of asthma and 43.9% were graded as severe asthma. The main causes of the fatal asthma attacks were respiratory infections, fatigue and stress. Insufficient education, low compliance, delay in treatment wih corticosteroids and other drugs, delay in emergency treatment, past histories of life-threatening attacks and hospitalization due to severe attacks were suggested to be risk factors of adult asthma death, Pulmonary emphysema showed relatively high frequency as a complication.View full abstractDownload PDF (709K) -
Katsuya Fujimori, Eiichi Suzuki, Masaaki ArakawaArticle type: Article
1998 Volume 47 Issue 1 Pages 48-53
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSH_1 antihistamines have been shown to have antitussive effects in patients with asthma and postnasal drip. In Japan, no study has been performed to determine whether orally administered oxatomide, H_1 antihistamine, can reduce the chronic cough seen in patients with post-upper-airway infection (postinfection). Patients who had chronic cough of more than three weeks' duration and a history of post-upperairway infection took part in the study. None had any history of nasal diswase, gastroesophageal reflux, bronchial asthma, or other chronic pulmonary disease. All patients were non-smokers, and none used ACE inhibitors. They had normal CRP concentrations, peripheral white blood cell and eosinophil counts, serum IgE concentrations, titers of cold agglutinins and antibodies to Mycoplasma pneumoniae, chest roentgenograms, and respiratory function tests. A prospective randomized, open design was used. The effect of one week of treatment with dextromethorphan (D) or with D plus oxatomide (D+O) on the severity of cough, as estimated by cough diary, were examined. Twenty-two patients entered the study, and 20 were eligible for efficacy and side-effect analyses. Nine patients receiving D and 11 receiving D+O completed the protocol. Patients' characteristics before the start of the study, such as severity and duration of cough, and laboratory data. were not significantly different between the two groups. From trial day 5 to 7, improved rates of cough were significantly higher with D+O than with D alone (p<0.05). Combination therapy with oxatomide and dextromethorphan reduces subjective perception of cough as estimated by cough diary. These results suggest that oxatomide, H_1 antihistamine may improve chronic cough in patients with post-upper-airway infection.View full abstractDownload PDF (577K) -
Hirotaka Itoh, Jyo Nishimura, Yoshihisa Nakamura, Kazuko Sugiyama, Shu ...Article type: Article
1998 Volume 47 Issue 1 Pages 54-56
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Jun Adachi, Hozumi Sumitsuji, Kaoru Endo, Takayuki Fukuzumi, Toshiyuki ...Article type: Article
1998 Volume 47 Issue 1 Pages 57-60
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1998 Volume 47 Issue 1 Pages 61-
Published: January 30, 1998
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Article type: Appendix
1998 Volume 47 Issue 1 Pages 62-
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1998 Volume 47 Issue 1 Pages 62-
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1998 Volume 47 Issue 1 Pages 63-64
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1998 Volume 47 Issue 1 Pages 65-68
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Cover
1998 Volume 47 Issue 1 Pages Cover3-
Published: January 30, 1998
Released on J-STAGE: February 10, 2017
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