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Volume 47, Issue 4
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Article type: Cover
1998 Volume 47 Issue 4 Pages Cover12-
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Cover
1998 Volume 47 Issue 4 Pages Cover13-
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1998 Volume 47 Issue 4 Pages App2-
Published: April 30, 1998
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Article type: Appendix
1998 Volume 47 Issue 4 Pages App3-
Published: April 30, 1998
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[in Japanese]Article type: Article
1998 Volume 47 Issue 4 Pages 387-393
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1998 Volume 47 Issue 4 Pages 394-396
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1998 Volume 47 Issue 4 Pages 397-403
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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Kazuhiko Matsumoto, Mikio Nishikawa, Hisakuni Hashimoto, Hiroshi Hayak ...Article type: Article
1998 Volume 47 Issue 4 Pages 404-412
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPharmacist's instruction is provided to asthmatic patients who received an inhaled steroid in Hamamatsu University Hospital. We studied influences of pharmacist's instruction on the rapeutic effects of an inhaled steroid, beclomethasone dipropionate (BDP). In 29 patients who had been treated with inhaled BDP under the physician's instruction for more than 3 months, we examined drug compliance, correctness of inhalation procedure and treatment score, symptom score, peak expiratory flow (PEF) values, and compared these before and after the instruction. The instruction was repeatedly provided at an interval of about one month. Patients who followed the indicated regimen were 55.2 and 93.1% before and after the instruction, respectively. An appropriate inhalation maneuver was respectively. An appropreate inhalation maneuver was performed in 24.1 and 93.1% of patients before and after the instruction, respectively. PEF values increased by 12.9±9.3% (mean±standard deviation, p<0.01) after the instruction. In conclusion, pharmacist's repeated instruction enhanced the therapeutic effects of inhaled BDP in patients with asthma.View full abstractDownload PDF (766K) -
Hitoshi Kawamoto, Toshiki Kimura, Masayuki Kambe, Toshihiko Kuraoka, T ...Article type: Article
1998 Volume 47 Issue 4 Pages 413-419
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSMuch interst has been focused on standardization of measurement of expired nitric oxide (NO) concentration. The aim of this study was establish a simple measurement of expired NO concentration. Subjects and Methods : This study included 5 healthy male adults. To clarify whether No is excreted in expired air constantly, its concentrations were measured while changing the flow rate. To examine the influence of NO derived from the nasal cavity, we compared expired NO concentrations sampled from the month with those sampled from the endotracheal tube inserted to the trachea at a constant flow rate serially. Results : Expired NO concentrations decreased in inverse with the flow rate. No may be serially excreted in expired air. When serial changes of expired NO concentratins sampled from the mouth were examined, its NO concentration initially reached a peak, then showed a plateau. Serial changes of those sampled from the endotracheal tube showed only a plateau. Plateau levels were not different between the two kinds. Therefore the peak , values may have been influenced by NO derived from the nose that falled in the trachea by inspiration. Plataue values appeared to represent airway and lung-derived NO. Conculusions : A simple measurement of expired NO concentration should be sampled from the mouth at a constant flow rate serially. Evaluating plateau values is appropriate for expired No concentration.View full abstractDownload PDF (666K) -
Kotaro Ukai, Shitau Hirata, Tetsurou Kimura, Kouji Yajinn, Yasuo Sakak ...Article type: Article
1998 Volume 47 Issue 4 Pages 420-425
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the morbidity of allergic rhinitis in downtown, rural area and fishing village by questionnaire in October, 1996. The morbidity rate of allergic rhinitis was 35.7% (370 subjects out of 1036) in downtown, 27.5% (266 out of 966) in rural area and 12.9% (273 out of 2112) in fishing village, and that of adult was 36.2% (314 out of 868) downtown, 28.9% (137 out of 474) in rural area and 12.07% (199 out of 1649) in fishing village, and that of child was 33.3% (56 out of 168) in downtown, 26.22% (129 out of 492) in rural area and 15.98% (74 out of 463) in fishing village. The morbidity of Japanese cedar pollinosis was 17.37% (180 out of 1036) in downtown, 13.77% (133 out of 966) in rural area and 2.60% (55 out of 2112) in fishing village. There was a statistcal difference (p<0.001)between the each district respectively. It was proved that the morbidity of allergic rhinitis in downtown was higher than the rural area or fishing village, and that in fishing village was the lowest in these districts.View full abstractDownload PDF (585K) -
A CLINICAL EVALUATION OF CLUSTERED IMMUNOTHERAPY IN HOUSE-DUST-MITE-SENSITIVE ADULT BRONCHIAL ASTHMAMakoto NagataArticle type: Article
1998 Volume 47 Issue 4 Pages 426-433
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSClustered immunotherapy (C-IT) using house-dust (HD) antigen was performed in eight HD-mite-sensitive adult bronchial asthmatics. Six mg of mequitazine was given 2 hours befofe each visit. For each visit, injections of antigen were performed four times with an hour interval. Either 0.1 ml of 10-fold concentration of the HD or a final dose at the end of the fifth week was determined as a maintenance dose. All cases have reached to ten-fold concentration of the HD antigen within 5 weeks and been able to introduce maintenance therapy without any systemic reaction. Following C-IT, a rapid increase in morning peak expiratory flow rate was observed which is follwed by decrease in clinical scores. Furthermore, an increase in mite-specific I G4 antibody and a decrease in peripheral blood eosinophils were observed 16 weeks following C-IT. Thses results suggest that C-IT using HD antigen can be performed safely and securely and provides rapid immunological responses as well as clinical benefit in HD-mite-sensitive adult asthmatics.View full abstractDownload PDF (814K) -
Kazuhiko Hanashiro, Noburu Tamaki, Tadayoshi Kosugi, Tomokazu kakazu, ...Article type: Article
1998 Volume 47 Issue 4 Pages 434-448
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe correlation between the outbreaks of asthme attack and meterologic parameters was analyzed in okinawa island which belongs to the subtropics. The epidemiologic outbreaks of asthme were investigated for 2 years from the asthme diaries described by 27 patients. The severity of asthme attack was expressed as the asthme acore on the basis of asthme diaries. The number of patients carried to hospitals by ambulance on asthme attacks was investigated for 3 years. Two-by-two contingency tables were computed for the meteorologic parameters and analyzed with the method of chi-square test. From the view point of asthma scores, the total scores of 27 patients were increased when a mean and a minimum temperature were respectively higher than each mean value in the period of investigation (p<0.05, respectively). From the view point of the number of patients carried to hospitals by ambulance on asthma attacks, it was suggested that asthma attacks tended to occur when a mean, a maximum and a minimum temperature, and a vapor pressure were lower than each mean value (p=0.0001, p=0.0001, p=0.0001, p=0.0002), and a barometric pressure was higher than a mean value in the period of investigation (p=0.0016).From the further analysis of these data by multiple regrassion analysis, it was suggested that the number of patients carried to hospitals by ambulance on asthme attacks was influenced by low temperature. In addition, it was suggested that the changes of meteorologic parameters on the passing over of typhoon, especially, the decrease of temperature and barometric pressure, were related to induce asthma attacks.View full abstractDownload PDF (1121K) -
Mitsuaki Kimura, Satoru Tsuruta, Takami YoshidaArticle type: Article
1998 Volume 47 Issue 4 Pages 449-456
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo study a role of Candida albicans in the development of atopic dermatitis (AD) from the viewpoint of cellular responses, we measured Candida-specific lymphocyte proliferation by flow cytometry in children with AD. There was no apparent age-dependent change in the level of Candida-SIF (stimulation index measured by flow cytometry) in either AD or non-atopic control subjects. The level of Candida-SIF was significantly higher in AD patients AD or non-atopic controls (178.0±89.3 vs 137.9±37.6, p<0.02), and the incidence of subjects with the elevated Candida-SIF level (≧200)was significantly higher in AD patients than in non-atopic controls (27.9% (17/61) vs 2.6% (1/38), p<0.005). There was no correlation between the levels of Candida-SIF and Candida-specific IgE antibody. These results suggest that Candida albicans contributes to the development of AD in some patients not only by Type I, but also by Type IV hypersensitivity reactions.View full abstractDownload PDF (684K) -
Tomoaki Iwanaga, Satoru Inuzuka, Naotsugu takahashi, Reiko Kishikawa, ...Article type: Article
1998 Volume 47 Issue 4 Pages 457-461
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThirty-nine patients with chronic persistent cough continuing more than eight weeks were examined regarding to their airway responsiveness to methacholine challenge using the Astograph (TCK-6100H, Chest Corp. japan). Of these, twenty-three individuals (59%) had airway hyperresponsiveness, leading to diagnose as having cough variant asthma (CVA). Patients with CVA had a higher percentage of eosinophils in peripheral blood and a lower forced expiratory volume in one second than those in non-CVA group. Furthermore, four patients (17%) developed the classic signs and symptoms of asthma, whereas 7 casas (30%) resolved their cough without further treatment and 12 cases (52%) continued to have CVA. These data suggested that a significant proportion of patients with chronic persistent cougt had CVA and some of them may develop to classic wheezing asthma.View full abstractDownload PDF (573K) -
Article type: Appendix
1998 Volume 47 Issue 4 Pages 462-
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1998 Volume 47 Issue 4 Pages 463-464
Published: April 30, 1998
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Article type: Appendix
1998 Volume 47 Issue 4 Pages 465-
Published: April 30, 1998
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Article type: Appendix
1998 Volume 47 Issue 4 Pages 466-469
Published: April 30, 1998
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Article type: Appendix
1998 Volume 47 Issue 4 Pages 470-473
Published: April 30, 1998
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Article type: Cover
1998 Volume 47 Issue 4 Pages Cover14-
Published: April 30, 1998
Released on J-STAGE: February 10, 2017
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