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Volume 49, Issue 7
Displaying 1-16 of 16 articles from this issue
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Article type: Cover
2000 Volume 49 Issue 7 Pages Cover20-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (851K) -
Article type: Cover
2000 Volume 49 Issue 7 Pages Cover21-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (851K) -
Article type: Appendix
2000 Volume 49 Issue 7 Pages App6-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
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Youske EgashiraArticle type: Article
2000 Volume 49 Issue 7 Pages 553-557
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
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Hiroshi TakenakaArticle type: Article
2000 Volume 49 Issue 7 Pages 558-561
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
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Kiyonobu Takatsuki, Yoshihiro Nishimura, Hitosi Maeda, Mitsuhiro Yokoy ...Article type: Article
2000 Volume 49 Issue 7 Pages 562-568
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the effects of anaphylactic challenge on nonadrenergic noncholinergic(NANC)relaxation response to electrical field stimulation(EFS)or to aminophylline in sensitized guinea pig tracheal smooth muscles. An anaphylactic challenge with ovalbumin(OA)reduced the relaxation response to EFS(20V.5Hz.300 pulse.duration 1 msec.), but the relaxation response to aminophylline was not affected by OA exposure. NG-monomethyl L-arginine, a nitric oxide(NO)synthesis inhibitor, reduced the relaxation response to EFS in the OA sensitized guinea pig. While the relaxation response to EFS on the sensitized guinea pig tracheal smooth muscle was significantly attenuated compared with that on the non-sensitized guinea-pig, there was no significant difference between the tracheal strip of OA challenge group and that of control group in sensitized guinea-pig under the existence of NO synthesis inhibitor. These results suggest that the attenuation of NANC relaxation response associated with sensitization plays an important role in airway hyperreactivity and is responsible for the decrease in NO amount.View full abstractDownload PDF (689K) -
Makoto Nagata, Michiya Yamaguchi, Hiroshi Shuhtoh, Yoshinori Terashi, ...Article type: Article
2000 Volume 49 Issue 7 Pages 569-576
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe aim of this study was to survey the self-assessment to the treatment of adult bronchial asthmatics in Saitama prefecture. A questionnaire on daily symptoms and medications was distributed to 2825 adult asthmatic subjects who were treated at 125 hospitals/clinics in Saitama prefecture between September 15^th and October 30^th 1998. More than half(52.7%)of patients described that their general condition of asthma was poorly controlled. Even among the patients described that their condition was good or fair, 30.2% of them had some asthmatic symptoms such as shortness of breath or nocturnal awakening. Although inhaled corticosteroids were used in 66.2%, the ratio of patients who used spacer and kept drug compliance as prescribed were 59.6% and 45.8%, respectively. According to the physician's reports, cysteinyl leukotriene antagonist was used in 35.7%, which was comparable to the total of another anti-allergic drugs(37.3%). These results suggest that more than half of asthmatic patients in Saitama prefecture were not satisfied with their conditions of the disease control. Furthermore, more thorough educations on the technique and compliance of inhaled corticosteroids would be required.View full abstractDownload PDF (778K) -
Fumiko KuritaArticle type: Article
2000 Volume 49 Issue 7 Pages 577-584
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSInflammatory mechanisms play an important role in the pathogenesis and the expansion of the skin lesion in AD. The serum levels of NO product, IL-8, RANTES and eotaxin, which are considered to an index of the inflammatory response, were measured in infants diagnosed as AD. The serum levels of NO product, RANTES and eotaxin were higher in the infantile AD patients with the systemic skin lesion compared with controls. The higher levels of NO product were shown with the expansion of the skin lesion. In AD patients, the serum levels of NO product were significantly correleted with the serum levels of eotaxin(r=0.615, p<0.001). These results suggest that NO product bears an important function in the allergic inflammation, which is concerned with the lesion expansion of the infantile AD patients and may be an index of the allergic inflammation.View full abstractDownload PDF (775K) -
Hiroshi Yoneyama, Mayumi Suzuki, Kouichi Fujii, Yasuhei OdajimaArticle type: Article
2000 Volume 49 Issue 7 Pages 585-592
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo examine the relationship between DPT and BCG vaccinations and development of atopic diseases, we studied on 143 children resident of the island of Kodushima, Tokyo Japan. This study dealt with the entire population of 0-3 years old(82), all of the first graders of the elementary school(31)and all of the first graders of the junior high school(30)on the Island. Results Among the 82 children aged 0-3, out of the 39 who received DPT vaccination, 10(25.6%)suffered from bronchial asthma and this ratio was significantly higher than among the children who have not received DPT vaccination(1 in 43, 2.3%), (p<0.01). This was also the case concerning atopic dermatitis(7 in 39, 18.0% vs 1 in 43, 2.3%)(p<0.05). The same trend was also observed if three diseases(bronchial asthma, allergic rhinitis and atopic dermatitis)were combined(22 in 39, 56.4% vs 4 in 43, 9.3%)(p<0.01). As to the context of BCG vaccination, there were no cases with atopic disorders among the tuberculin positive first graders of the elementary school. No such relations, however, were observed among the first graders of the junior high school at all. Findings From these results, we conclude that DPT vaccination has some effect in the promotion of atopic disorders, while successful BCG vaccination inhibits the development of atopic disorders, although the preventive effect of BCG may not last for many years.View full abstractDownload PDF (729K) -
Fumitoshi Yoshimine, Mayumi Sasagawa, Yukiyoshi Kon, Seigo Yamaguchi, ...Article type: Article
2000 Volume 49 Issue 7 Pages 593-599
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSNocturnal worsening is an important problem in asthma management. We evaluated the efficacy of two sustained-released theophylline formulations, administered twice-a-day(TD)and once-a-day(UP). In 20 asthmatic patients with low peak expiratory flow rate(PEF)in the morning(<80% of predicted)administered TD(mean dose 475 mg/day)for 2 weeks, we evaluated PEF, diurnal variability of PEF, symptom score, results of spirometry and serum theophylline concentration(STC)and then changed theophylline, from TD to UP(mean dose 470 mg/day)for 2-4 weeks. PEF in the morning was higher during the UP period(mean±SD:335±110L/min)than during the TD period(mean±SD:308±95L/min)(p<0.05), and diurnal variabirity of PEF was lower during the UP period(17.1±8.0%)than TD period(22.9±13.4%)(p<0.05). However, there were no changes in PEF at night or daytime, symptom score, spirometry parameters or STC during the study period. The improvement in morning PEF observed in this study was consistent with the differences in pharmacokinetics between the two theophylline formulations. Morning PEF was increased during the UP period, probably because STC in the early morning during the UP period was higher than STC during the TD period.View full abstractDownload PDF (698K) -
Yoshiki Kobayashi, Makoto Nagata, Hideaki Yamamoto, Yoshio SakamotoArticle type: Article
2000 Volume 49 Issue 7 Pages 600-603
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSuplatast tosilate has been shown to inhibit generation of Th2-type cytokines in vitro and used in the treartment of allergic diseases. Although the exact mechanism remains unknown, this compound attenuates the eosinophil infiltration in the asthmatic airway. In the present study, we examined whether suplatast tosilate directly modulates eosinophil migration in response to inflammatory mediators in vitro. Suplatast did not modify the spontaneous migration of eosinophils. On the other hand, eosinophil migration in response to PAF(1 μM)was significantly inhibited by 1 μM suplatast. Similarly, IL-5(100pM)-induced eosinophil migration was inhibited by 1μM suplatast. These results suggest that suplatast tosilate inhibits eosinophil locomotion in response to PAF or IL-5 and thereby attenuates infiltration of the cells in allergic inflammation.View full abstractDownload PDF (379K) -
Article type: Appendix
2000 Volume 49 Issue 7 Pages 604-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2000 Volume 49 Issue 7 Pages 604-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (77K) -
Article type: Appendix
2000 Volume 49 Issue 7 Pages 605-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2000 Volume 49 Issue 7 Pages 606-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (470K) -
Article type: Cover
2000 Volume 49 Issue 7 Pages Cover22-
Published: July 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (411K)
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