Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 50, Issue 11
Displaying 1-17 of 17 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    2001 Volume 50 Issue 11 Pages Cover4-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.Cover4
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    2001 Volume 50 Issue 11 Pages Cover5-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.Cover5
    JOURNAL FREE ACCESS
    Download PDF (1241K)
  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages App5-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.App5
    JOURNAL FREE ACCESS
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  • GRAND DESIGN FOR HEALTH CARE IN 21 ST CENTURY
    Eitaka Tsuboi
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1077-1079
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1077
    JOURNAL FREE ACCESS
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  • EBM AND ASTHMA PREVENTION AN MANAGEMENT GUIDELINES
    Sohei Makino
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1080-1082
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1080
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  • META-ANALYSIS OF PHARMACOTHERAPIES FOR ALLERGIC RHINITIS
    Makoto Yasuda, Kenji Dejima, Yasuo Hisa, Kotaro Ozasa
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1083-1089
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1083
    JOURNAL FREE ACCESS
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    We performed meta-analysis usingthe data in literatures of the clinical study related to pharmacotherapies for allergic rhinitis in Japan as evidences. We extracted double-blind studies which used first-generation antihistamines, early-stage second-generation antihistamines, late-stage second-generation antihistamines and arachidonic acid metabolite-receptor antagonists as investigational drugs. In meta-analysis of first-generation antihistamines and early-stage second-generation antihistamines, significant differences between them were detected in final overall improvement and usefulness. In meta-analysis of early-stage second-generation antihistamins and late-stage second-generation antihistamines, significant differences between them were detected in usefulness and seleepiness as an adverse effect. In meta-analysis of late-stage second-generation anti-histamines and arachidonic acid metabolite-receptor antagonists, significant differences between them were detected in final overall improvement and usefullness. These results indicate a historical trend in the development of drugs including measures to deal with sleepiness as an adverse effect. The arachidonic acid metabolite antagonists appeared to be promising among the oral drugs for allergic rhinitis, although data related to the arachidonic acid metabolite antagonists are still few and further collection of them is necessary.
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  • ANALYSIS OF FACTORS INFLUENCING ON ANISAKIS SPECIFIC IgE ANTIBODIES
    Yoshihiro Umebayashi
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1090-1095
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1090
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    Anisakis-specific IgE (AsIgE) was examined in 84 cases of acute urticaria (AU) and 100 cases of atopic dermatitis (AD). Gender, age, disease category (AU or AD) and serum IgE value of the patients were compared with AsIgE. Univariate analysis showed that there was significant correlation between age and AsIgE, and between serum IgE and AsIgE. Serum IgE was significantly higher in AD than in AU. Age was significantly higher in AU than in AD. AsIgE was positive value in 26 cases (31%) of AU and 25 cases (25%) of AD. There were no significant differences between them. In these cases, however, AsIgE was significantly higher in AU than in AD. Percentage of patients with high AsIgE value (>class 2) was significantly higher in AU (20 cases, 24%) than in AD (3 cases, 3%), Multivariate analysis using discriminant analysis and logistic regression analysis showed that the most influential factor on AsIgE was disease category (relative risk = 16.87), and the second was age (relative risk = 1.05), Serum IgE and gender were considered not to influence on AsIgE. It is possible that Anisakis or related antigens have something to do with urticaria in AU patients with high AsIgE value.
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  • CLINICAL SIGNIFICANCE OF MEASUREMENT OF URINARY LEUKOTRIENE E_4 IN ASTHMATIC PATIENTS WITHOUT ATTACK
    Yukio Kawagishi, Rokuo Oosaki, Haruhisa Mita, Muneharu Maruyama, Nobuk ...
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1096-1101
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1096
    JOURNAL FREE ACCESS
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    To evaluate clinical significance of measurement of urinary leukotriene E_4 (LTE_4) in asthmatic patients without attack, we measured urinary LTE_4 in 68 asthmatic patients without attack and investigated its correlation with severity of asthma, %FEV_1, bronchial hyperresponsiveness and peripheral eosinophil counts. Values of urinary LTE_4 were significantly higher in the asthmatic patients (113.6±9.7pg/mg;cr) than in healthy control subjects (67.8±4.7, n=31), and the level of urinary LTE_4 was in proportion to the severity of disease. Urinary LTE_4 showed significant negative correlation with %FEV_1 in atopic patients (Rs=-0.43, p=0.025, n=28), which was not recognized in non-atopic patients. Urinary LTE_4 showed no significant correlation with bronchial hyperresponsiveness and peripheral eosinophil counts. Our findings suggested that basal LTE_4 in urine reflected chronic airway inflammation of asthma.
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  • THE STUDY OF 18 CASES OF ASPIRINURTICARIA AT DERMATOLOGY OF YODOGAWA CHRISTIAN HOSPITAL : On the Difference between Aspirin Asthma and Aspirin Urticaria
    Takashi Nakamura, Yoshie Ookami, Akiharu Tamaki, Kazuhiro Hayashi
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1102-1105
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1102
    JOURNAL FREE ACCESS
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    Aspirin intolerance manifests itself as two clinical symptoms, urticaria/angioedema and asthma. However, there is seldom patient of aspirin intolerance who has the both symptoms, urticaria and asthma. So we suspect that the pathogenic mechanism for aspirin urticaria differs from that for aspirin asthma. We examined 18 patients of aspirin urticaria at dermatology of Yodogawa Christian Hospital, especially as to oral aspirin challenge test. All patients had no symptom of asthma. Threshold dose evoke urticaria/angioedema after ingesting 100 to 500 mg of aspirin (average, 311 mg). Urticaria/angioedema occurred within 50 minutes to 14 hours (average, 3 hours 16 minutes) after ingesting aspirin. The dose and the time of oral aspirin challenge test for these 18 patients were more spent than those for reported patients of aspirin asthma. These results support the opinion that aspirin urticaria has the different pathogenic mechanism from aspirin asthma. In addition, we experienced one patient of aspirin intolerance which caused hyperemia and edema of the bulbar conjunctiva. She had no symptom of urticaria and asthma, and had the both character of aspirin urticaria and asthma as to aspirin challenge test. We propose that aspirin intolerance is classified in reaction of the skin (urticaria/angioedema) and reaction of the mucosa (asthma), and it has an intermediate type.
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  • CLINICAL USEFULNESS OF THE HISTAMINE RELEASE TEST IN ASSESSING ADULT ASTHMATIC PATIENTS WHO KEEP HAMSTER
    Reiko Seki
    Article type: Article
    2001 Volume 50 Issue 11 Pages 1106-1113
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1106
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    Recently, the prevalence of keeping pets, such as hamsters and guinea pigs, at home has been increasing in Japan. The number of adult asthmatic patients who keep hamster (HKA) has increased, and accounted for 20% of all pet owners in 1997. Histamine release tests (HRT) were performed on 28 patients of HKA, who consulted with the outpatient clinic of our department, and the results were compared with CAP-RAST. HRT were performed with peripheral blood obtained from each subject, and histamine content was measured by fluorescent assay. 7 in 12 RAST positive patients and 4 in 16 RAST negative patients in HKA had histamine release titer reaction over 15 ng/ml. HRT and CAP-RAST scores were correlated in HKA, and HRT could be evaluated before and after stopping keeping hamsters in five subjects to find decreased HRT scores in all.The results obtained indicate that those tests were useful for the clinical diagnosing and monitoring of HKA.
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages 1114-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1114
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages 1115-1116
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1115
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages 1117-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1117_1
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages 1117-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1117_2
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages 1118-1120
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1118
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 11 Pages 1121-1125
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1121
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    2001 Volume 50 Issue 11 Pages Cover6-
    Published: November 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.Cover6
    JOURNAL FREE ACCESS
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