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Article type: Cover
2002 Volume 51 Issue 5 Pages
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Article type: Cover
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Atsushi Komiyama
Article type: Article
2002 Volume 51 Issue 5 Pages
397-399
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Daisuke Hata, Mitsutaka Shiota, Yoshika Tamura, Maki Miyazaki, Kayo Oh ...
Article type: Article
2002 Volume 51 Issue 5 Pages
400-410
Published: May 30, 2002
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To investigate the efficacy of the long-term treatment with pranlukast, a specific cysteinyl leukotriene receptor antagonist, in pediatric patients with mild to moderate asthma, 77 pediatric asthmatic patients who received pranlukast for up to 36 months (mean duration, 13 months) were evaluated retrospectively. Treatment with pranlukast resulted in improvements from the pretreatment baseline in asthma attacks per month, episodes of hospitalization, and episodes of intravenous amynophiline treatment on emergent clinic visits. The percentage of responders who had marked or moderate improvements in the abovementioned parameters of asthma control was 79%. In conclusion, pranlukast caused significant improvements in long-term asthma control in pediatric patients with mild to moderate asthma.
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Mitsuru Adachi, Akihiro Morikawa, Kyohsuke Ishihara
Article type: Article
2002 Volume 51 Issue 5 Pages
411-420
Published: May 30, 2002
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The asthma insights & reality in Japan survey was aimed to assess the current status of asthma treatment and management in Japan. We used random digih dialing to identify current asthmatics in households throughout Japan. Throughout Japan, 38132 households were contacted. A detailed survey on asthma management was conducted among 803 of these households, 401 adults and 402 children. More than half had experienced a daytime asthma attack during the previous month. More than one third had experienced an asthma attack at night during that same period. About 70% of the adults and 60% of the children with asthma reported some limitation on activities of daily life. About 50% of adults and 80% of children had never undergone any pulmonary function testing. Only 6% of adults and 7% of children's parents were aware that "airway inflammation" was a major cause of asthma. Moreover, only 12% of adults and 5% of children were using inhaled steroids. There was an especially large gap between subjective perception of asthma control and objective findings in patients with severe asthma. Many Japanese asthmatics tended to underestimate the severity of their condition. Asthma management in Japan falls far short of goals stated in the guideline. These findings emphasize the need for increased awareness of the burden of asthma in Japan.
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Naomi Kondo, Takahide Teramoto, Ryosuke Inoue, Osamu Fukutomi, Eiko Ma ...
Article type: Article
2002 Volume 51 Issue 5 Pages
421-429
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We conducted a longitudinal investigation with the QOL questionnaire (revised version 2001) before and after the 4-week-administration of a leukotriene receptor antagonist pranlukast. A significant improvement in the<4 yrs group was observed at week 1, and that in≧4yrs group at week 2. Under these conditions, the overall QOL score, physical domains and mental domains, significantly improved in both the<4 yrs group and the≧4 yrs group. Overall, a slight correlation was observed between ratio changes in QOL scores and differences in symptom scores. However, no correlation was found in part of patients, suggesting that the QOL questionnaire allows measurement of mental changes in the patients themselves and their parents or caregivers for therapeutic effects which cannot be determined with ordinary physical findings only. In "event present" group, a significant difference in physical and mental domains was revealed by the comparison of QOL scores before and after administration. And furthermore in "event absence" group, the p-value for physical domain and mental domain was 0.0505 and 0.0912 in the<4 yrs group, respectively, 0.0101 and 0.0446 in the≧4 yrs group, respectively. The above results led us to consider the QOL questionnaire (revised version 2001) useful for routine medical care. Furthermore, pranlukast was considered useful for improvement not only of physical symptoms of bronchial asthma but also of the patient's QOL, although the placebo effects in this open trial must be considered.
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Shougo Tomita, Hajime Suzuki, Kazuo Akiyama
Article type: Article
2002 Volume 51 Issue 5 Pages
430-438
Published: May 30, 2002
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To study the clinical significance of cockroach allergen in adult asthmatics in Japan, we performed intradermal skin test to four commercial base cockroach extracts. The specific IgE antibody to cockroach was measured in sera by CAP-RAST. Positive rates of immediate intradermal skin response to cockroach extracts were 10.2〜12.6%. Positive rate of CAP-RAST to cockroach was 12.6%. We performed bronchial provocation test on 6 cockroach sensitive asthmatics. Immediate asthmatic response was provoked in 2 cases and late asthmatic response was provoked in one case. Positive histamine release from peripheral leukocytes (HRT) to cockroach was shown in cockroach sensitive asthmatics. RAST-inhibition studies of cockroach showed several inhibition patterns and indicated partial cross-reactivity between cockroach species and mite. These results indicate that there is a possibility that cockroach is one of the important inhalent allergens in Japan.
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Akira Yamasaki, Kazuko Nishimura, Hiroyuki Sano, Katsuyuki Tomita, Hir ...
Article type: Article
2002 Volume 51 Issue 5 Pages
439-442
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Satsuki Okita, Katsunori Sugisaki, Takuya Ueno, Takehiko Shigenaga, Ei ...
Article type: Article
2002 Volume 51 Issue 5 Pages
443-446
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
447-449
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
450-451
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
452-454
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
455-456
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
460-461
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
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Article type: Appendix
2002 Volume 51 Issue 5 Pages
463-467
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Article type: Cover
2002 Volume 51 Issue 5 Pages
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Published: May 30, 2002
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