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Volume 55, Issue 7
Displaying 1-25 of 25 articles from this issue
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Article type: Cover
2006 Volume 55 Issue 7 Pages Cover24-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Cover
2006 Volume 55 Issue 7 Pages Cover25-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages App22-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages App23-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Tetsuo ShioharaArticle type: Article
2006 Volume 55 Issue 7 Pages 777-780
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Sankei NishimaArticle type: Article
2006 Volume 55 Issue 7 Pages 781-790
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Chiho Goda, Shigeaki OhnoArticle type: Article
2006 Volume 55 Issue 7 Pages 791-793
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Hironori SagaraArticle type: Article
2006 Volume 55 Issue 7 Pages 794-810
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAlthough salmeterol (SLM) /fluticasone propionate (FP) combination has been widely used in the world, this is not yet available in Japan. The combination risk was concerned based on overseas reports about adrenal suppression with high dose FP or asthma exacerbation from undesirable administration of SLM without ICS. Therefore, in this article, it was reviewed the evidence of both efficacy profile and safety profile of the SLM/FP for the combination with FP and SLM, and it was concluded that safety concerns of SLM and FP are low and the benefits of SLM/FP combination exceed the risks, at least they are used properly. Since SLM/FP combination has synergic effect clinically, this will reduce high dose used FP and they also reduce using SLM without ICS. The compliance will be improved by the combination. To improve asthma control, Japanese clinicians expect to be available this combination soon.View full abstractDownload PDF (3916K) -
Atsuko Adachi, Tatsuya HorikawaArticle type: Article
2006 Volume 55 Issue 7 Pages 811-819
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBackground: A number of cases of oral allergy syndrome (OAS) to fruits with birch pollinosis have been described. The antigen of Alnus sieboldiana (alder) trees which are massively planted on Rokko Mountain appeared to be highly similar to birch pollen. Methods: We took the medical history of pollinosis and OAS, measured pollen-specific IgE (CAP-RAST) and performed prick tests of causative fruits to the outpatients of the two hospitals in different areas. Result: In Hanshinkan district, at the foot of Rokko Mountain, we experienced 9 cases of OAS among 377 outpatients. All 9 cases had alder specific-IgE. The prevalence rate of OAS was 11.0% in the alder specific-IgE-positive patients and 0% in the alder specific-IgE-negative patients in the area. On the other hand, in Higashiharima district where less alder trees exist and further from Rokko Mountain, 19 OAS patients were documented among 2000 outpatients. Six of the 19 patients with OAS did not have alder specific-IgE. The prevalence rate of OAS was 6.8% in the alder specific-IgE-positive patients and 11.8% in the mugwort specific-IgE-positive patients in the area. Conclusion: In Hanshinkan, alder pollinosis seems to be most important for the cross reactivity to the OAS. In Higashiharima, mugwort pollinosis may be more important than alder pollinosis for the cross reactivity to the OAS.View full abstractDownload PDF (1477K) -
Harumasa Ito, Kenshi Sekimura, Nobuhito Sasaki, Hiroo Nitanai, Yutaka ...Article type: Article
2006 Volume 55 Issue 7 Pages 820-826
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBackground: Neutrophil releases several mediators during inflammation, including neutrophil elastase (NE) that impairs bronchial epithelial function. The stress response and stress proteins protect cells against a variety of cytotoxic conditions. Accordingly, we tested the hypothesis that bronchial epithelial heat shock protein (Hsp-70) would protect a NE-induced cell injury. Methods: Bronchial epithelial cells (BECs) obtained by bronchial brushing under bronchoscopy were cultured and used for experiments. Expression of Hsp-70 in BECs was confirmed by Western blot and flowcytometric analysis. To test Hsp-70 in BECs, induction of Hsp-70 protein into BECs was carried out by liposomebased delivery system. Introduction of Hsp-70 into BECs were examined by direct fluorescence microscope examination and flowcytometric analysis. NE-induced cytotoxicity was evaluated by cell culture supernatant LDH assay and cell detachment assay. Results: Higher expressions of Hsp-70 were observed in BECs, which were induced by sodium arsenite. Over expression of Hsp-70 in BECs reduced NE-induced cell injury. Introduction of Hsp-70 protein into BECs by liposomal delivery decreased LDH release, and inhibited necrosis and apoptosis of the cells by NE as compared to untreated control. Conclusion: These data suggested that Hsp-70 in BECs may inhibit NE-induced airway epithelial damage. Liposomal delivery of Hsp-70 into BECs may be a possible means of protecting bronchial epithelium against inflammatory airway diseases including acute and chronic bronchitis.View full abstractDownload PDF (828K) -
Takeo Sato, Shin-ya Oominami, Takamitsu Souma, Kiyofumi Hagiwara, Shou ...Article type: Article
2006 Volume 55 Issue 7 Pages 827-831
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 75-year-old woman was admitted to our hospital because of abnormal lung shadow and necrosis of the left feet. She had a history of Raynaud's phenomenon from her twenties. On admission, she was diagnosed as having diffuse systemic sclerosis (SSc) and Sjogren's syndrome (SjS) because of scleroderma, interstitial pneumonia (IP), positive result of anti-Scl-70 and SS-A antibody, sicca, decreased tear excretion, and dysfunction of salivary glands. Seventy days after amputation of her left leg, she presented with edema, hypoxemia, chest discomfort, and fever. Blood test revealed inflammation and cardiac echography revealed pericardial effusion with a collapse sign of right atrium, thereby leading to the diagnosis of cardiac tamponade. After starting the daily dose of 20mg of prednisolone, the pericardial effusion and cardiac tamponade sign disappeared. Pericarditis is seen in half of patients with SSc and rarely with SjS, and is usually asymptomatic. Pericarditis due to SSc has been reported unresponsive to steroid therapy, but several cases of steroid responsive pericarditis due to SSc or SjS have been reported. Clinically, they shared inflammatory responses and the presence of IP in the cases of SSc, which will be important when considering the pathogenesis and treatment of pericarditis due to SSc or SjS.View full abstractDownload PDF (697K) -
Shintaro Suzuki, Yoichi Nakamura, Yutaka Kawano, Kiyoshi NishiokaArticle type: Article
2006 Volume 55 Issue 7 Pages 832-836
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSNatto is a Japanese traditional food made from formented soybeans. We report a case of anaphylaxis caused by natto and review the literature. The patient was a 22-year-old man who showed systemic eruption with itching and pectoralgia about 10 hours after eating a meal containing natto. Results of skin tests for soybean allergen were negative, and the allergen remained unidentified. We then used a food elimination trial to confirm the allergy. However the patient did not refrain from eating natto, and he had three anaphylactic reactions might have been caused by natto. Each event occurred 10 to 14 hours after he ate a meal containing natto. We perfomed detailed examinations to determine the allergen. First, the prick-by-prick tests with natto and its characteristic viscous yarn-like surface were done and yielded positive results. Next, a provocation test with commercial natto (50g) was performed and caused systemic eruption and pectoralgia about 9 hours after ingestion of the natto. The patients' plasma histamine level was elevated during the anaphylactic event. Anaphylaxis caused by natto was diagnosed. Recent studies have shown that the anaphylaxis caused by natto is of late-onset. Late-onset anaphylaxis can be considered one of IgE-mediated allergic reactions. The viscous surface of natto contains poly-γ-glutamic acid (PGA). The hypothesized mechanism of late-onset anaphylaxis is delayed absorption or release of PGA into the bowel. In our case, hte patient ate heated natto, we therefore speculate that suspect allergens were heat resistant. Patients with natto allergy must not cat natto, whether or not it is cooked or heated. Natto may induce allergic reactions up to a half-day after ingestion; thus, the clinical course and patient's diet must be considered during medical examination. Natto has recently gained popularity as a health food in foreign countries. The existence or natto allergy should be more widely recognized.View full abstractDownload PDF (706K) -
Article type: Appendix
2006 Volume 55 Issue 7 Pages 837-846
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 847-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 847-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (49K) -
Article type: Appendix
2006 Volume 55 Issue 7 Pages 847-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (49K) -
Article type: Appendix
2006 Volume 55 Issue 7 Pages 848-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 849-850
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 850-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 851-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 852-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 853-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2006 Volume 55 Issue 7 Pages 853-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Appendix
2006 Volume 55 Issue 7 Pages 853-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Cover
2006 Volume 55 Issue 7 Pages Cover26-
Published: July 30, 2006
Released on J-STAGE: February 10, 2017
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