Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 29, Issue 4
Displaying 1-13 of 13 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1980 Volume 29 Issue 4 Pages Cover19-
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.Cover19
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1980 Volume 29 Issue 4 Pages Cover20-
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.Cover20
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1980 Volume 29 Issue 4 Pages Misc7-
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.Misc7
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  • STUDIES OF AN EXPERIMENTAL MODEL OF ASTHMA IN MONKEYS : I. Bronchial Responses to Methacholine and Histamine in Monkeys with Beta-Adrenergic Blockade
    Tetsuhiro Ohmi, Suetsugu Mue, Makoto Takahashi, Gen Tamura, Toshiharu ...
    Article type: Article
    1980 Volume 29 Issue 4 Pages 149-156
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.149
    JOURNAL FREE ACCESS
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    Bronchial reactivity to methacholine and histamine in monkeys with beta-adrenergic blockade was studied by measuring respiratory impedance. Propranolol (5mg/kg body weight/day) was given orally for 10 days and the degree of beta adrenergic blockade was assessed by changes in hyperglycemic and chronotropic responses to the injection of adrenaline. Propranolol treatment produced a more distinct beta-adrenergic blockade in cynomolgus than in Japanese monkeys. In both groups, the bronchial responses to histamine challenge by injection or aerosolized administration were not altered after propranolol treatment. Propranolol treatment increased to bronchial reaction to methacholine injection although it showed no significant change to aerosolized methacholine.
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  • STUDIES ON CHANGES OF CYCLIC NUCLEOTIDES AND NOREPINEPHRINE AFTER EXERCISE IN CONTROL AND SENSITIZED GUINEA PIGS
    Hideo Banno, Tatsuo Satake, Kazuo Ryuge, Masanari Awaya, Masashi Kato, ...
    Article type: Article
    1980 Volume 29 Issue 4 Pages 157-164
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.157
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    We compared the exercise-induced changes in plasma norepinephrine and cyclic nucleotides in plasma and tracheal tissue of control and sensitized guinea pigs. Guinea pigs were sensitized by inhalation of Konjac "Maiko" and exercise was on a 50 cm diameter wheel (40 rpm, 8 min). Cyclic GMP and AMP levels in plasma and tissues were examined by RIA, and plasma norepinephrine levels were examined by the radioenzymatic method. In the trachea, the cGMP levels decreased remarkably in the controls (p<0.01), while in the sensitized group they increased only slightly after exercise. The cAMP levels increased from 759±166 to 1193±259pmol/g in the controls while they did not increase significantly in the sensitized group. The ratio of cGMP : cAMP decreased significantly in the controls, but did not change in the sensitized group. In the lung, the levels of cGMP and cAMP did not change in both groups, so, the ratio of cGMP : cAMP did not change, too. In the plasma, the cGMP levels increased statistically in the controls (p<0.05), while in the sensitized group they increased remarkably from 11.0±2.2 to 28.2±10.8pmol/ml (p<0.01). The cAMP levels increased remarkably from 36.5±8.9 to 89.1±14.6pmo/ml in the controls (p<0.001), while they increased slightly in the sensitized group (p<0.01). Plasma norepinephrine levels increased remarkably from 3.96±1.42 to 15.50±6.07ng/ml in the controls (p<0.001), while they did not increase significantly in the sensitized group. These result suggest that the sensitization by inhalation develop a tendency to constrict the smooth muscle of airway at exercise.
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  • T-CELL REGULATION IN THE PFC RESPONSE OF HUMAN B-CELLs
    Teruaki Hongo, Soichi Haraguchi, Makoto Yazaki, Tetsumichi Matsuo, Tak ...
    Article type: Article
    1980 Volume 29 Issue 4 Pages 165-170
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.165
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    Antibody formation to SRBC activated by PWM was investigated, using human peripheral blood lymphocytes and an immature B-cell line in a system of T-B cell cooperation. Plaque forming cells (PFC) assay was by Cunningham's direct method. T-cell enriched or depleted fractions were obtained by the SRBC rosetting method. follows: 1) High (280±30 PFC) and low (40±8 PFC) responders were found in healthy adult humans. 2) T-B cell cooperation experiments between high and low responders, whose HLA antigen types were completely different, showed that high respondere T-cells (T^h) induced the maturation of low responder B-cells (B^1) to form PFC as well as high responder B-cells (B^h). Low responder T-cells (T^1) induced neither B^h nor B^1 to form PFC. 3) T^h could activate the immature B-cell line to generate PFC, but T^1 could not. We conclude that PWM-inducred antibody production against SRBC in the high and/or low responders is regulated by T-cell functions in vitro.
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  • IN VITRO REACTIVITY OF PERIPHERAL BLOOD LYMPHOCYTES TO PHYTOMITOGENS AND THE PRESENCE OF ANTI-B LYMPHOCYTE ANTIBODIES IN THE SERA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
    Michihito Okubo, Hiroto Hoshina, Mikiko Kato, Koju Kamata, Jun Okada, ...
    Article type: Article
    1980 Volume 29 Issue 4 Pages 171-178
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.171
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    Twenty-two untreated patients with systemic lypus erythematosus (SLE) were studied for the in vitro responsiveness of their peripheral blood lymphocytes to phytomitogen such as phytohemagglutinin (PHA), concanavalin A (Con A) or pokeweed mitogen (PWM), and also tested for the presence of serum factor(s) which could inhibit mitogenic responses of normal cells. There was marked reduction in the responses of lymphocytes from a group of patients with active SLE to all these mitogens in comparison with the responses of cells from normal individuals. When the disease activity decreased, the perfectly normal response to either PHA or Con A was observed. In contrast, the response to PWM in most patients remained to be impaired during disease quiescence. We have also found inhibitory factor(s) present in the sera of patients with active SLE which could alter the mitogenic responses of normal cells. The inhibitory effect of SLE sera was most profound in the response to PWM. Of interest is that cold type antibodies to a non-T cell population were also found in 56% of the selected sera which had the inhibitory activity. Defective responsiveness of SLE lymphocytes to PWM might be the result of the effects of such antibody activity in vivo.
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  • SLOW REACTING SUBSTANCE (SRS) FROM HUMAN LEUKOCYTES : I. Release of SRS from Human Neutrophil Leukocytes by Calcium Ionophore A23187
    Shoji Yoshida, Hisao Tomioka, Akira Kumagai
    Article type: Article
    1980 Volume 29 Issue 4 Pages 179-186
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.179
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    The release of slow reacting substance (SRS) from human leukocytes by calcium ionophore A23187 (CaI) stimulation was studied. Either basophil leukocytes or neutrophil leukocytes was able to release significant amount of SRS in the presence of calcium ions by CaI dose-dependently. However, neither eosinophil leukocytes nor lymphocytes released SRS. The neutrophil-derived SRS appeared to be identical to SRS-A from basophils and mast cells in terms of the contractile activity to different smooth muscle preparations and physicochemical properties. Moreover, the contractile activity of neutrophilderived SRS was reversed by FPL55712, a specific endorgan antagonist of SRS-A. The amount of SRS released from neutrophils was smaller than that from basophils. The ability of neutrophils from asthmatic patients to release SRS was greater than neutrophils from normal individuals. We suggested that neutrophil-derived SRS might play an important role in some types of allergic reaction or allergic disease.
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  • LEUKOCYTE ADHERENCE INHIBITION (LAI) TESTS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
    Yoshifuji Matsumoto, Keiko Eguchi
    Article type: Article
    1980 Volume 29 Issue 4 Pages 187-193
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.187
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    To investigate the applicability of the leukocyte adherence inhibition (LAI) test in patients with systemic lupus erythematosus (SLE), the tests were performed with peripheral blood leukocytes from 35 lupus patients by using antigens such as native DNA (n-DNA) and denatured DNA(d-DNA). An optimal antigen dose was 0.25mg/ml of DNA. This DNA concentration did not inhibit adherence of normal leukocytes. The cultured supernates from patients reactive to n-DNA inhibited the adherence of the leukocytes from a non-reactive patient. LAI indexes and positive rates of LAI test against n-DNA in SLE were significantly higher than normal individuals, but those against d-DNA were same as normal. LAI test results for n-DNA and d-DNA did not correlate. The LAI test did not distinguish between active and inactive lupus. Moreover, there was no significant correlation between LAI indexes and titers of anti-DNA antibody, serum complement levels or administered doses of steroid hormone. These results indicate that LAI tests against n-DNA may be useful in in vitro assay for cellmediated immunity in SLE.
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  • [title in Japanese]
    Article type: Appendix
    1980 Volume 29 Issue 4 Pages 195-197
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.195
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  • [title in Japanese]
    Article type: Appendix
    1980 Volume 29 Issue 4 Pages 198-
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.198
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  • [title in Japanese]
    Article type: Appendix
    1980 Volume 29 Issue 4 Pages 199-202
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.199
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  • [title in Japanese]
    Article type: Cover
    1980 Volume 29 Issue 4 Pages Cover21-
    Published: April 30, 1980
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.29.Cover21
    JOURNAL FREE ACCESS
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