Chinese medical prescriptions usually have one or more herbs in common, enabling the intra-relation of the prescriptions to be analysed. Computer science provides the methodology with which the analysis of the polypharmacy-structure of the chinese medical presciption can be undertaken, and it is that methodology with which we are concerned in this report. Data should be collected in following 4 aspects: 1) the subject as doctor, school, country, etc. 2) classical and modern publications. 3) individual herbs contained in the prescriptions. 4) classical and modern concepts of disease. Such data should then be analysed in either of 2 ways: 1) M-D-SCAL (Kruskal), quantification of the fourth type (Hayashi), when similarities are made. 2) quantification of the third type (Hayashi) for 2-mode data. And graphing of the results will facilitate. Thanks to the technologic progress, calculations are made by micro computer.
The group of 12 “Shimotsu-to rui” chinese medical prescriptions containing Angelica acutiloba Kitag., Cnidium officinale Mak., Paeonia lactiflora Pall. and Rehmannia glutinosa (Gaertn.) Libosch were analysed by multiple dimensional scaling analysis (M-D-SCAL), quantification of the third type (QT-III) and cluster analysis (C.A.). M-D-SCAL were carried out in 2 ways, by that of the angle method and the Jaccard's coefficient. Using the angle method in analysing the 12 prescriptions, the “Orengedoku-to” groups and the diuretic & peptic prescription groups were clarified and some prescriptions containing specific herbs were located in a marginal region, and these locations were fit for traditional information. QT-III gave a simular location of the prescriptions to the result of the M-D-SCAL with Jaccard's coefficient. In this method, not only the prescriptions, but also the herbs simultaneously can be located. This made possible the interpretation of the intra-relations between the 12 prescriptions, in terms of the axis pertaining to the herbs. Certain herbs consistently fall into the same categorical region, indicating a shared relationship and corresponding to the traditionally conceived “Yaku-tsui” or “paired herbs”.
This is a case report of primary hyperthyroidism, treated by Shakanzo-To (a herbal medicine) alone, without any other medical intervention. Effects of Shakanzo-To was proved by the measurement of serum thyroid hormone levels. The patient was 32 y. o. female. Struma and exophthalmus were apparent. Weight loss was also noticable (-10kg/2 years). Serum thyroid hormone levels were abnormally high (T3=421ng/dl, T4=36.0μg/dl, TSH=1.0μU/ml). Thyroid scintigram showed diffuse uptake. 131I uptake ratio was 71.5%/24 hours. She was diagnosed as primary hyperthyroidism. According to the “Sho” (the diagnostic approach of oriental medicine, KANPO), Shakanzo-To (water-boiled) was prescribed. Six weeks afterwards, the hormone levels decreased (T3=291, T4=17.3). From that time, we used the same “Shakanzo-To” medicine, but in the form of chemically-extractedgranules. After four weeks, the hormone levels increased again (T3=291, T4=24.7). So, we used again the former Shakanzo-To (water-boiled). Then the hormone levels decreased once again six weeks later (T3=210, T4=17.3). TSH levels remained less than 1.25μU/ml. We believe it important that effects of Shakanzo-To seem to be demonstrated by the improvement of the thyroid hormone levels.