Weights of extracts, ultra violet absorption spectrum, thin-layer chromatography and proton nuclear magnetic resonance spectrum were used for discrimination of occurrence of reaction between constituents of a pair of crude drugs during decoction. Distinction in the examination heads above mentioned between individual decoction and simultaneous decoction were investigated. A few of pairs were found to have some changes and these observations indicated possibility of the reactions of constituents in the crude drugs.
This study was done to know what kind of signs and symptoms (Sho) of Oriental Medicines were detected at the early feverish stage (great yang: Taiyo-Byoki) in children. Methods were as follows. 103 patients of early feverish stage were treated with only plant's drugs of Kakon-to (K), Mao-to (M), Keisi-to (KE), the half mixed drug of Mao-to and Keisi-to (M-KE), the half mixed drug of Kakon-to and Keisi-to (K-KE), and Shomakakon-to (S). The evaluation of the effectiveness was done wether or not the Sho resolved in 3 days. Results were as follows. 1. M-KE showed significantly higher effect than K in exterior (Hyo) drugs (p<0.005). 2. The effectiveness of S, which was believed to act on interior (Ri) position of the body, showed highest in all drugs used. Moreover, this effect showed significantly higher than those of K and KE (p<0.005). 3. In the strong (Zitsu) patients with no spontaneous sweating, M-KE showed the same result as above. S showed significantly effective than M, K, KE and K-K (p<0.01-0.001). 4. From the aspect of sex difference, there was not significant in the both sex. This finding suggest that the children were neutral sex in Oriental Medicine. 5. From the aspect of age difference in exterior drugs, the high effect were observed K-KE (100%), M-KE (90%), and KE (73%) in less than 2y/o. On the other hand, the high effect were observed M-KE (86%), and M (70%) over 3 y/o. These results suggested wide distribution obtained in less than 2y/o became more focusing with age. 6. Above findings also implied us that the children in early feverish stages had the tendency to take interior and middle position between fullness (Zitsu) and weakness (Kyo).