SDDSの50倍散を市販の配合飼料に混じ,各群2匹の子豚に,薬剤実景それぞれ1.25mg,2.5mg,5.0mg,10.0mg/kg/dayを朝夕2回に分けて投与し続けた.薬剤投与後8日目に,トキソプラブマ原虫(自然感染豚より分離し,マウスにて継代中の)TT株の腹腔内感染(マウス腹腔内増殖型虫体5×106/pig),または経口感染(感染マウス2匹/pig)を実施した.その後,感染無投薬対照豚の発症が軽度であったので,経口感染群では,4日後にふたたび感染マウス2匹/pigを餌食せしめた.さらに10日後に眼結膜感染(5×106/pig)を行ない,腹腔内感染群では,28日後に,前報4)で使用したHG株の再接種(2×107/Pig)を試みた.その結果,1.25mg/kg/dayの投薬量でも,経口感染に対して抵抗を示し,発熱も,パラジテミアも完全に阻止された.一方,腹腔内感染群では,2.5mg,5.0mg,10.0mg/kg/day各群とも,完全に発病が阻止された.ただしバラジテミアは10.0mg/kglday群の1例に1回観察されたが,その他の供試豚では,すべて陰性を示した.試験豚計12例を,初回トキソプラズマ感染後60~74日の間に殺処分し,体内の諸臓器,リンパ節,筋肉等における原虫の存否を検索した.その結果,投薬群は全例陰性であったのに比し,対照群の半数では,心筋,横隔膜,肋間筋または脳から,原虫が検出された.以上の成績から,SDDS散剤の経口投与は,豚トキソプラズマ症感染防御にきわめて有効であることが認められた.

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魚臭に対する脱臭作用,あるいはmouseのEhr11ch腹水癌に対して制癌作用を有しない市販のコハダ酸を特定の条件下で処理することによって,制癌作用を有する活性型に変化せしめる方法に関する報告である.即ち1,蒸溜水にCO2ガスを飽和せしめ,これに低濃度でコハク酸を溶解せしめて10゜C以下で24時間以上放置して得る.2.マレイノ酸に常温,常圧で水素添加して得る方法.3. コハク放溶液に炭聚カルシウム,または水最化カルシウムを添加して得る方法.などである.

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The fine blood vascular system in tl?e pancreas was elucidated by observing his-tological preparations and transparent preparations from 31 chickens which had beeninjected with India ink containing 10% gelatin into the arterial system.There are two main branches supplying the pancreas, the Ramus pancreatico-duodenalis and the Ramus pancreaticus. These rami, then, run through the inter-lobular connective tissue and give an A. interlobularis to this tissue. The Aa. intra-lobulares arise from the A. interlobularis and enter each lobule, in which they aredivided into arterioles. In the interacinar tissue they make up a capillary network, from which aflerent vessels are sent to the islets of Langerhans (Fig. l) . Theseafferent vessels form wide, convoluted glomerulus-like sinusoids both in small A andin small B islets of Langerhans. Numerous efferent vessels which arise from sinusoidsat the periphery of the islets of Langerhans enter the interacinar tissue. They an-astomose with the interacinar capillary network and drain into venules (Fig. 2).The venous blood empties into the V. interlobularis via the Vv. intralobulares.In the lobus splenicus, the afferent vessels in large A islets of Langerhans form a wide, convoluted rete-mirabile-like sinusoid network (Figs. 4, 7, and 12). From these rete-mirabile-like structures, it is suggested that the large A islet of Langerhans may secreteconcentrated glucagon in the fowl.A complicated venous plexus exists in the wall of the pancreatic duct (Fig. 5).Its venous blood drains into the V. interlobularis near the pancreatic duct. This factsuggests that the reabsorption of the water content from the pancreatic juice may bedone in this portion of the excretory duct of the pancreas.

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Etiological studies were carried out on infectious atrophic rhinitis of swine (AR)now prevailing in Japan. A total of 654 swab samples of swine nasal discharge wereexamined to establish any relationship between the bacterial flora of the nasal cavityand the occurrence of this disease.Of these samples, 413 had been obtained from 6 swine farms in Nagasaki, Ibaraki, Saitama, Hiroshima, Kanagawa, and Yamanashi Prefectures. Other 214 samples hadbeen collected from clinically AR-suspected hogs which had been shipped from 26prefectures scattered nearly all over Japan to the Shibaura Abattoir, Tokyo, and sub-jected to the post-mortem examination for pathological change of the turbinate bones.The results obtained are summarized as follows.l. Turbinate atrophy was seen in 173 pigs (7l.3%) which had been shipped from25 prefectures all over Japan and slaughtered at the Shibaura Abattoir, Tokyo. Theseresults clearly indicate that AR has been spread among swine in Japan to a considerablylarge extent.2. Bordetella bronchiseptica was detected in relation to the clinical symptomsand turbinate atrophy. So that it was considered to be the most important pathogenicagent of infectious atrophic rhinitis of swine now prevailing in Japan.Pasteurella multocida was partially suspected as a pathogenic factor on only onepig farm. Haemophilus suis was not recognized as the primary pathogen of thisdisease. Micrococcaceae, Streptococus, Escherichia, and Mycoplasma were i nd i catedas species forming the normal bacterial flora of the nasal cavity of pigs.3. The bacterial flora of the nasal cavity of infected pigs correlated to the riseand fall of the disease. B. bronchiseptica was generally detected in the early ormiddle stage of the disease. On the other hand, Klebsiella-Enterobacter showed atendency to be isolated as a dominant species in a later stage of the disease.4. B. bronchiseptica was detected abundantly in the ethmoid turbinate evenwhen it could not be isolated in the nasal turbinate in a later stage of the disease.From this fact, it

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Calcium pantothenate and pantethine were investigated for influence on the estrouscycle and reproductive performance in mice deficient in pantothenic acid. Female miceof the dd N strain, 40 days of age, were placed on control diets (CLF, A, CA-1) for 21days. Only those which had exhibited at least 2 regular cycles of 4, 5, or 6 days eachduring this period were used (Table 2). As shown in Fig. l, they were divided iutto5 groups.I) The estrous cycle and diestrous stage per cycle were prolonged by feeding ondiets deficient in pantothenic acid for 70 days (Table 5).2) There was a tendency to decrease in implantation and increase in incidenceof fetal mortality among mice given CLEA diets deficient in pantothenic acid forthree weeks (Table 6).3) The decline in sexual function caused by feeding on a pantothenic aciddeficient diet was improved by subcutaneously injection with calcium pantothenatcrand pantethine (Tables 5 and 6).

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