In order to evaluate the efficacy of pipemidic acid (PPA) on sinusitis, a well controlled study was carried out according to the same protocol in cooperation with 11 clinics in Japan. The results obtained were as follows.
1. PPA was used for 153 patients with sinusitis. The 148 cases judged by doctors in charge consisted of 35 cases of acute sinusitis, 33 cases of acute exacerbation of chronic sinusitis and 80 cases of chronic sinusitis. The 115 cases judged by the committee consisted of 28 cases of acute sinusitis, 29 cases of acute exacerbation of chronic sinusitis and 58 cases of chronic sinusitis. The bacteriological efficacy was investigated in 117 cases.
2. As to the overall clinical efficacy of PPA, the ratio of effectiveness were 48.0% in doctor's judgement and 59. 3% in committee's judgement.
3. In the cases of infections due to GNB, the ratio of effectiveness was 58.1% in doctor's judgement and 70.4 % in committee's judgement, and PPA was confirmed to have superior efficacy against infections due to GNB.
4. With respect to the bacteriological results, PPA eliminated causative organisms in 58.1%. It was remarkable that PPA eradicated GNB and indicated organisms in the ratios of 68.4% and 82.4% respectively.
5. With respect to the subjective symptoms, objective findings and X-ray findings, the improvement ratio of PPA was higher for GNB infections than for the infections of other organisms.
6. Incidence of side effects was 9.2%. They were mainly gastrointestinal disturbance and were not serious. From the above results, PPA was considered to be excellent chemotherapeutic agent for sinusitis due to GNB.
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