A new electrodiagnostic technique was devised in order to determine the prognosis of recurrent laryngeal nerve. It simply consists of electrical stimulations of the vocal cord and determination of the threshold to produce spasm of the cord. Clinical and laboratory studies revealed that the new technique is clinically useful. It would be called “Electrostimulation test of the vocal cord”.
The results of the present investigation are the followings:
1. The normal threshold in humans ranged from 35 to 48 volts for a stimulus of 1 msec (average 40.0 volts), from 23 to 38 volts for a stimulus of 5 msec Caverage 30.4 volts), and from 23 to 32 volts for a stimulus of 10 msec in duration (average 28.2 volts).
2. In cases of recurrent laryngeal nerve paralysis, the threshold of Electrostimulation test of the vocal cord presented fairly systematic relationship to electromyographic findings. In general, cases with normal potentials of the laryngeal muscles showed a normal threshold of vocal cord excitability test. Cases with predominant fibrillation potentials showed a threshold between the normal value and 100 volts. Cases in which the laryngeal muscles were electrically silent did not present spasm of the vocal cord by any stimulus less than 100 volts.
3. Prognosis of paralysis in cases with a threshold less than 50 volts was favorable. In cases with a threshold between 50 and 100 volts, it was difficult to determine the prognosis on the basis of results of a single test. Follow-up examinations were required. A decrease in threshold in follow-up test suggested a favorable prognosis, whereas an increase in threshold indicated an unfavorable one. In the latter cases, no recovery was expected.
4. In cases of so-called internus paralysis the threshold of vocal cord excitability test fell within the normal range.
Because of its simlicity, indolence and considerable reliability, the vocal cord excitability test can be one of the routine tests for recurrent laryngeal nerve paralysis in ordinary laryngological clinics.

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Forty-three cases of malignant tumors of the head and neck were treated with the intra-arterial infusion of 0.12% hydrogen peroxide and Mitomycin C (MMC) during the last three years and seven months. Clinical and histopathological examinations were performed.
The 0.12% hydrogen peroxide solution was prepared as follows immediately before the infusion, that is, Nicotinic acid (Nyclin) 40mg as a vasodilator, oxidol 10ml and heparin 1000 U. were added to 250ml of 5% dextrose-Ringer's solution.
The 0.12% hydrogen peroxide solution thus prepared was infused with an infusion pump in about an hour period, and immediately after that MMC 4mg in solution form was injected by the one-shot method.
This infusion was performed every day for about 10 days. Total dosage of MMC was about 40mg.
The therapeutic results were as follows;
1) Macroscopically, the therapeutic effects were more enhanced than those of the single infusion of MMC (over 40mg).
2) Side effects of this method were not so many and severe as those of the single infusion of MMC except a few cases of the retrograde infusion.
3) The normograde infusion was better suited for this plan of therapy than the retrograde infusion.
4) No side effects upon liver, kidney, heart and lung from this plan of treatment were noted.
5) Histopathologically, degenerative findings were remarkably recognized in the interstitial tissues, especially in the vessels and fibrous tissues when only hydrogen peroxide was infused without MMC. But in cases of the combined infusion (hydrogen peroxide and MMC), they were observed not only in the iterstitial tissues but also in the parenchyma of tumor.
The effect of the combined infusion were seemed to be due to potentiation of the both agents.

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Introduction: The body surface of warm-blooded animals including man is vibrating constantly, but invisibly. Although the natures of this invisible vibration has not been satisfactorily determined ; the phenomenon is thought to be due to-muscle fiber tonus or the other factors, for example, the action of autonomic nervous system and heart beat. This vibration has been called Microvibration by ROHRACHE (R1 954).
KAWATA (1958), of this laboratory, noted that it was possible to detect a small change to auditory stimuli in the original waves of Microvibration (MV), before visualization.
The purpose of this paper is to report a new method for measuring the auditory acuity in adult objectively by means of the MV-response to auditory stimulation.
Methods: To record the MV it was used a specially designed pickup with the vacuum tube (RCA 5734)(see figure 1). This small pickup had a square measure of 2.0×4.5 cm² and a weight of 20 gm. In actual use, it was connected to MV-analyzer C Nihon Koden Co. Tokyo) for the vibration to be multiplied in amplitude.
The sound stimulation consisted of white noise, generated from NYA-II audiometer (Nagashima Co. Tokyo), which was coupled to MV-analyzer in such a way that the beginning of stimulation was measured exactly. The blockdiagram of the stimulating and recording equipments used is shown in Figure 2.
The subjects with normal hearing or various hearing deficits were previously examined by routine auditory test with pure tone and white noise, and kept in bed in a supine position, in a dark sound proof room. Their eyes were closed, and they were made as relaxed as possible. Then the pickup was laid loosely on the body surface (mainly on the palpebral area) for MV-recording.
When the original wave of MV was stable C generally about 18 min. after resting), the subjects were stimulated with white noise through a receiver. Each stimulus lasted 3 or 5 sec, and at adequate intervals the stimuli were repeated with different intensities using both ears.
Problems encountered:
1. MV-wave initial irregularity. MV-wave, as shown in Fig. 4, was irregular and unstable immediately after the subject reclined on the bed. The irregularity, however, disappeared after 18 min. of resting in the supine position. Hence a waiting period was neccessary in order to accurately measure the responses.
2. The interval of stimulations. With 30 dB above the auditory threshold, the same ear was stimulated for 3 sec at intervals of 10, 20 and 60 sec respectively. In each case the 10th response at an interval of 60 sec was still presented, as shown in Fig. 6, while the one at interval of 10 or 20 sec was already indistinct.
3. The recognition of response. The positive responses were identified by the increased amplitude only of the original MV-wave during stimulation. In order to determine the response threshold an increased amplitude with latent period within 1.0 sec after stimulation was interpreted as the response.
Results:
1. The most sensitive position for recording MV-response among the forehead, palpebra, cheek, palm and leg was at palpebral area as shown in Fig. 3.
2. The response-differences between the right and the left palpebral area were no remarkble as shown in Fig. 8.
3. In spite of very intense sound intensities, the MV-responses were not elicited at the palpebral area of subjects with deafness and peripheral facial nerve paresis. A similar MV-response was also elicited by stimulating the external ear with cold (20°C) water, as shown in Fig. 7.
4. The responses were devided into following three types ; on-response, intermediate response and off-response as shown in Fig. 10. In actual recordings, various combinations of these respose-types were seen as shown in Table 1.
5. The latency was studied on 691 cases which responded with various intensities. as shown in Table 2. The values within 1.0 sec were found in 74.0% of the cases.

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