耳鼻と臨床

頭頸部がん早期死亡例について

井上憲文

1984 年 30 巻 2 号 p. 107-114
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_107

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The Tokyo University Hospital Department of Otorhinolaryngology treated 423 first-time cases of head and neck cancer from 1974 to 1978. Forty-five of the patients died of cancer within a year of their initial visit to the tumor clinic. Early death was classified according to the pathological cause. The most frequent cause of death was squamous cell carcinoma, which developed: in the ear (2 cases out of 4 died within a year), in the nasal cavity (the single case died), and in the neck (1 of 5 died). Malignant lymphoma was the second most frequent cause of death. The period from the onset of the cancer to the initiation of treatment was less than 5 months in 31 out of the 45 early death cases. Delayed initiation of treatment after the onset of cancer did not seem to be related to early death. Development of the original focus of cancer was the direct cause of death in 25 cases. Sixteen other cases showed metastasis of cancer to remote sites. The stage of development of cancer was examined. In carcinosis, 20 out of 30 cases were at stage IV, and in malignant lymphoma, 3 cases were at stage 11, 3 cases at III and 2 cases at IV.

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下顎骨軟骨肉腫の一症例

西岡出雄, 佐々木裕美, 近森義則, 丘村煕, 柳原尚明

1984 年 30 巻 2 号 p. 115-119
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_115

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The authors reported a case of submandibular chondrosarcoma, and discussed the pathology, symptoms and treatment of this rare disease after reviewing the literature. The patient was a 52-year-old woman with a painless swelling of the left preauricular lesion, of three months duration. The CT sialography clearly delineated a tumor arising at the left mandibular ramus; the tumor was removed with preservation of the facial nerve. The tumor was diagnosed as chondrosarcoma by histopathological examination. A half year later, the tumor recurred at the lower end of the ramus. Wide total removal of the tumor with hemimandibulectomy was performed and 6000 rad postoperative radiation was given. No recurrence was seen for a year postoperatively.

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喉頭癌における免疫療法の意義

PS-K, SPGの場合

高橋廣臣, 岡本牧人, 八尾和雄, 松林隆

1984 年 30 巻 2 号 p. 120-125
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_120

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Eighty six patients with laryngeal carcinoma were treated with a radical course of Linac X-ray therapy. The radiotherapy was followed by surgery, only when local recurrence became evident. Thirty cases out of 86 patients were given PS-K or SPG as non-specific immunopotentiators at the same time as radiotherapy. For these 30 cases, the immunological parameters, two-year survival rate and two-year preservation rate of the larynx, were compared with those of the remaining 56 cases given irradiation alone. There were no significant differences in the parameters of the humoral factors (CH 50, serum immunglobulin) between 30 cases of radioimmunotherapy and the control group. The parameters of cellular immunity, peripheral blood lymphocyte counts and T-cell counts, decreased similarly with not only radiotherapy but also radioimmunotherapy in the six months after the beginning of the therapies. The PHA blastformation rate of the peripheral blood lymphocytes returned to the pretreatment level within five months of the beginning of the radioimmunotherapy, while in the control group it did not return within seven months. The two-year survival rates were 93% (28/30) in the group of radioimmunotherapy and 86% (48/56) in the control group. The rates of those with the larynx preserved reached 73% (22/30) and 57% (32/56) respectively.

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セフォチアムの口蓋扁桃組織内濃度

中村正, 厳文雄, 渡辺仁, 木村洋

1984 年 30 巻 2 号 p. 126-130
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_126

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声帯層構造を考慮した声帯振動の基礎的研究

都築達

1984 年 30 巻 2 号 p. 131-152
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_131

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This study has been performed mainly in order to clarify the vibratory mode observed in the muscle layers of the vocal fold. It was also the purpose of this study to observe how the muscle layer influences on the vocal fold vibration itself during the phonation. An experimental sound was obtained by use of canine larynges. As constrasting media, lead pellets were inserted into various areas of the vocal fold, under the epithelium, inner layer, and also deep inner layer (muscle layer). For data collection, an X-ray stroboscope developed in our laboratory was driven by a trigger from a laryngostroboscope. The experimental sounds were produced while 1) all the internal laryngeal muscles were activated, 2) all the internal laryngeal muscles but the cricothyroid were activated and 3) only the cricothyroid was activated. Pellets movements were X-ray cinematographically taken and analyzed afterwards with a film motion analyzer. Regular movements were not obtained in the pellets inserted into the muscle layer in all cases. From these results mentioned, it was concluded that the muscle layer might not play an important roll as a vibratory body for producing sound while the motion of the epithelium membrane of the vocal fold must be essential for it.

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¹⁴C-DL-8280の耳鼻咽喉科領域組織内移行分布に関する実験的研究

村井兼孝, 馬場駿吉, 立沢晴男, 津村光義

1984 年 30 巻 2 号 p. 153-156
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_153

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The distribution of antimicrobial agents in infected tissue would be essential for their application to the sites of infection. Taking accounts of the viewpoint, we had reported the distribution of 2 nalidixic acid analogs in the tissues which are related to otorhinolaryngology. We investigated here the distribution of nalidixic acid analog DL-8280. This agent was supplied by Daiichi Seiyaku Co., Ltd. Autoradiography was performed 30 minutes after intravenous administration of ¹⁴C-DL-8280 in 100 μCi/20mg/kg to JAW rabbit. Such care was taken in filling the carboxymethylcellulose paste into paranasal cavity, nasal cavity, oral cavity and external ear canal not to damage mechanically. Horizontal frozen sections parallel to mandibular basis were cut in 50cm thickness in a cryostadt. Blackening of ¹⁴C-DL-8280 was most significant in soft palate and its expanse which was apparently the same gland-like tissues as soft palate when stained which hematoxyline and eosin. Significant radioactivity was recognized in pharynx, the cartilage of external ear canal and muscle. The levels were low in septal cartilage, concha nasalis and cochlea. Blackening was scarcely seen in brain. Macro-autoradiography can be one of the useful means for the evaluation of chemotherapeutic agents for possible clinical application.

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CMX耳用液の聴器へおよぼす影響に関する実験的研究

佐藤喜一, 小川明, 宮崎巨, 出島律子

1984 年 30 巻 2 号 p. 157-166
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_157

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Ototopical solution with some kinds of antibiotics induced sensorineural deafness, if it was administered to the middle ear for long duration. By the above reason, it is important examination toclarify the ototoxicity of new developing ototopical solution of CMX (cefmenoxime) before clinical application. 31 animals of Hartley strained guinea pigs were used in this study. In 28 animals, after performing of artificial perforation at each ear drum, eachleft sided middle ear cavity was received 1% CMX ototopical solution 0.2 ml for 5 days. Three animals were received 1% CMX through the minute tubes which were touched with left middle ear cavity. Other right sided ear cavities were received 0.5% CP ototopical solution in 6 animals, 0.3% GM in 5 animals and2.0% KM in 5 animals. Among the remained animals, right cochleae of 8 animals were destroyed by surgery for the purpose of unilateral ABR recording. After performing of artificial perforation, right middle ear cavities of 4 animals were observed without administration of drug, and 3 animals of control group were not received any treatment. Afterfinishing the above procedure, each animal wasfixed by the method of intravitalfixation with 10% neutral formalin solution for pathohistological examination. The microscopic observation was focused the damage of Corti's organ, especially degeneration of the hair cells. As the results of the above experimental procedure, no remarkable changes of Corti's organ were present in 31 ears, which were received CMX. Degeneration of outer hair cells at lower part of basal turn was appeared in only one animals of KM receiving animals.

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小児鼻アレルギーに対する経口剤Ketotifenシロップの臨床効果

登坂薫, 増山敬祐, 北尾健二郎, 北尾友幸, 石川哮

1984 年 30 巻 2 号 p. 167-175
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_167

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Twenty eight children (6-15y), who were suffered from nasal allergy, were treated with Ketotifen syrup. Patients received Ketotifen syrup (0.8-2.0mg/day) in two divided dose for oral administration. And we obtained following results.(1) The efficacy rate in sneezing attack was 65.4%, in nasal discharge was 52%, in nasal obstruction was 62.5%.(2) Some improvements in at least one of three major symptoms were noted within 3 days after administration of the drug in 14.3% of the patients, within 1 week in 60.7%, within 2 weeks in 75%, within 3 weeks in 78.6%.(3) Side effect was observed only in one patient with erythema. These results suggested that Ketotifen syrup was highly effective in the treatment of nasal allergy in children.

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鼻アレルギー患者における寒冷負荷時の末梢血中β-エンドルフィンおよびカテコラミンの変動

前田仁, 藤谷哲造

1984 年 30 巻 2 号 p. 176-182
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_176

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Various kinds of stress may contribute to develop the symptom of nasal allergy. The plasma content of Noradrenalin (N. A.) and β-Endorphin (β-End) was measured in response to Cold Pressor Test (CPT) loaded as a stress factor in 11 patients with nasal allergy and in 10 healthy controls. N. A. was measured by HPLC with a voltammeter and β-End by radioimmunoassay. Plasma N. A. is an appropriate index of sympathetic nervous function and β-End is a parameter of emotional stress. Blood pressure significantly raised by CPT in both groups. Plasma N. A. and β-End significantly increased by CTP in the allergic group. Thus, patients with nasal allergy have hyperreactivity of the sympathetic nervous system and emotional hyperresponsiveness by CPT. Cornell Medical Index (CMI) of 121 subjects with nasal allergy was investigated, resulting in a characteristic tendency of inadequacy, hypersensitivity, anger and especially easy irritability. These excessive reactions which are believed to associate the central pathway may have a causative relationship to the nasal hyperreactivity of nasal allergy.

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耳鼻咽喉科医の立場よりみた片頭痛

特に群発頭痛について

調賢哉

1984 年 30 巻 2 号 p. 183-185
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_183

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血中濃度よりみたペプロマィシン投与法の検討

藤井正人

1984 年 30 巻 2 号 p. 187-189
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_187

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頭頸部がんに対する多剤併用療法 (VMBM)

甲能直幸

1984 年 30 巻 2 号 p. 190-195
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_190

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東大耳鼻科における頭頸部がん化学療法

井上憲文

1984 年 30 巻 2 号 p. 196-198
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_196

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Bleo-VEMFHA同調化学療法原法変法における薬剤血中濃度の検討

大川正直

1984 年 30 巻 2 号 p. 199-203
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_199

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当科における癌化学療法の成績

野口明彦, 井上哲生, 内田正興

1984 年 30 巻 2 号 p. 204-207
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_204

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シスプラチンの体内動態

堀内正敏, 三宅浩郷, 犬山征夫

1984 年 30 巻 2 号 p. 208-210
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_208

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頭頸部癌に対するCPDDとPeplomycinの併用療法

増野精二

1984 年 30 巻 2 号 p. 211-214
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_211

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CisplatinとPeplomycinの使用経験

宮原裕, 馬谷克則, 吉野邦俊

1984 年 30 巻 2 号 p. 215-218
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_215

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頭頸部癌におけるCisplatin, 5 FU併用投与の臨床経験

広川剛夫, 竹田千里

1984 年 30 巻 2 号 p. 219-221
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_219

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マイボーム腺原発の腺癌症例に対するアドリアマイシンとアクラシノマイシンAの使用経験について

工藤典代, 藤田洋祐, 金子敏郎

1984 年 30 巻 2 号 p. 222-225
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_222

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頭頸部腫瘍に対するアドリアマイシンの使用経験

嶋田文之, 武宮三三

1984 年 30 巻 2 号 p. 226-228
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_226

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PS-Kが効果があつたと思われる進展下咽頭がん長期生存例の3例

小野勇

1984 年 30 巻 2 号 p. 229-231
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_229

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5FUおよびその誘導体のPharmacokinetics

江口実美

1984 年 30 巻 2 号 p. 232-235
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_232

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頭頸部癌におけるアンジオテンシン II

昇圧癌化学療法の臨床応用

粟田口敏一, 高坂知節, 草刈潤, 河本和友

1984 年 30 巻 2 号 p. 236-240
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_236

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The enhancement of cancer chemotherapy by Angiotensin-induced Hypertension is based on the fact that the autoregulation of blood flow is lacking in tumor tissues. Therefore, the selective increase in tumor blood flow enhances the chemotherapeutic effect by increasing the delivery of anticancer drug administrated systemically. We induced hypertension with Angiotensin II in 11 head and neck cancer patients when anti-cancer drugs were administrated systemically or infused into the artery. The good clinical response was observed in 5 out of 11 (45.5%)(5 cases including 2 complete (CR) and 3 partial responses (PR)). These results indicate that the effect of anti-cancer drugs was markedly enhanced by this procedure. Furthermore, the effect of the drugs appeared in far earlier than in the treatment without induced hypertension.

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上顎洞癌に対するCarboquone動注療法

本田哲朗, 竹田千里

1984 年 30 巻 2 号 p. 241-242
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_241

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われわれが行つている上顎癌の併用療法について

松村祐二郎, 野村和, 井上定三, 福与和正, 秦一雄, 三好真琴

1984 年 30 巻 2 号 p. 243-246
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_243

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頭頸部癌に対する化学療法の役割

三橋重信, 平野実

1984 年 30 巻 2 号 p. 247-251
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_247

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集学治療におけるphytohemaggiutininの応用

坂口幸作, 奥田稔

1984 年 30 巻 2 号 p. 252-254
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_252

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中咽頭がんの局所動注化学療法

集学治療の一環として

松浦鎮, 佐竹文介, 牧野総太郎, 高橋敬一, 境野宏治

1984 年 30 巻 2 号 p. 255-258
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_255

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頭頸部癌に対するビタミンA併用療法

小宮山荘太郎

1984 年 30 巻 2 号 p. 259-261
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_259

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頭頸部癌の集学的治療におけるわれわれの化学療法

窪田哲昭

1984 年 30 巻 2 号 p. 262-265
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_262

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化学療法が放射線療法に先行したワルダイエル咽頭輪原発病期IIびまん性非ポジキンリンパ腫の治療成績

竹生田勝次

1984 年 30 巻 2 号 p. 266-267
発行日: 1984/03/20
公開日: 2013/05/10

DOIhttps://doi.org/10.11334/jibi1954.30.2_266

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