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53 巻, 8 号
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本間 遜1979 年 53 巻 8 号 p. 347-349
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (515K) -
特にOEP特異抗体を指標として…その5マウス緑膿菌感染実験及びマクロファージ食菌時におけるOEP-HA価の変動について里見 信子, 原中 勝征, 国井 乙彦, 真下 啓明1979 年 53 巻 8 号 p. 350-358
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーIn OEP (common protective antigen of Pseudomonas aeruginosa) immunized mice, OEP-HA (hemagglutination) titer was decreased by intraperitoneal inoculation of P. aeruginosa, especially Fisher's serotype 2 and NC 5 strain. All of OEP immunized mice survived from the challenges by Fisher's seven serotypes strains. Otherwise all of non-immunized mice died within 48 hours by seven serotypes challenges.
In vitro system, the enhancing effects of the phagocytosis of mice spleen macrophages by anti-OEP-antibody were common to all of Fisher's seven serotype, and the decreasing tendancy of OEP-HA titer in these supernatants was observed.
The OEP-HA titer and Formalized bacterial agglutination titer were measured in various γ-globulin products before and after the absorption by OEP antigen. Only in Fisher's serotype 2 and NC 5 strains their titer was decreased.
By injection of γ-globulin products to mice, serum γ-globulin concentration and OEP-HA titer were increased a little, but their therapeutic effectiveness to P. aeruginosa infection was reavealed in our previous reports.
When γ-globulin products were absorbed with OEP antigen, their therapeutic effects were depressed.
In conclution, anti-OEP-antibody has therapeutic effect to the all of Fisher's serotypes of P. aeruginosa infection and the hig h level of antibody in bloo d is not always needed fo r the immunotherapy.抄録全体を表示PDF形式でダウンロード (968K) -
1. インフノレエンザウイルス及びパラインフルエンザウイルスに対する血清HI抗体価への影響今西 二郎, 尾石 金蔵, 朴 鎮彬, 岸田 綱太郎, 唐木 利朗, 佐々木 修, 松尾 昭夫, 戸田 正弥, 永田 久紀1979 年 53 巻 8 号 p. 359-365
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーDrops of human leukocyte interferon (HL-IF) were instilled into the nasal cavityof 86 volunteers once a day from the middle of December 1977 to the end of March 1978. Blood was drawn for the determination of serum antibody titers from all volunteers before and after interferon administration. In the interferon-treated group, the rise in hemagglutination-inhibition antibody titers against the three strains of influenza viruses was not significantly different from that in the control group. The rise in antibody titer against the parainfluenza virus, type 2, CA, was less in the interferon group than in the placebo group, although there were no significant differences in theantibody titer rise against parainfluenza viruses except type 2, CA.抄録全体を表示PDF形式でダウンロード (663K) -
2. 発熱及びかぜ様症状に対する効果今西 二郎, 尾石 金蔵, 朴 鎮彬, 岸田 綱太郎, 唐木 利朗, 佐々木 修, 松尾 昭夫, 戸田 正弥, 永田 久紀1979 年 53 巻 8 号 p. 366-369
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーDrops of human leukocyte interferon (HL-IF) were instilled in the same manner as the first report of this study. All volunteers completed a questionnaire about fever and subjective symptoms of upper respiratory tract infection. There were fewer complaints of fever resulting from upper respiratory tract disease in the interferon treated group. Moreover, fevers higher than 39°C were found only in placebo-treated recipients. Fourteen of 41 volunteers in interferon-treated group complained of subjective symptoms due to upper respiratory tract infection, whereas 28 of 43 volunteers in placebo-treated group. This difference was significant. Thus our study shows that prophylactic interferon can influence upper respiratory tract disease.抄録全体を表示PDF形式でダウンロード (478K) -
安達 正則, 松岡 康夫, 東 冬彦, 藤森 一平1979 年 53 巻 8 号 p. 370-373
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーA 41-year-old housewife with pneumonia due to M. pneumoniae is reported with particular reference to marked pleural effusion observed. Her cardinal symptoms include fever, cough and chest pain.
Massive pleural effusion has been rare in M. pneumoniae pneumonia and this is the sixth reported case in the literature. Hypogammaglobulinemia of 0.5 g/100 ml. was also noted in this case.抄録全体を表示PDF形式でダウンロード (6220K) -
庄田 昌隆, 滝上 正, 村田 道里, 川村 明義1979 年 53 巻 8 号 p. 374-378
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーA 24 year old male patient was admitted because of enlargement of the lymph nodes on November 17, 1977. Two weeks before admission he had a sudden onset of high fever lasting for seven days, followed by red rashes on the face and trunk four days later. Rashes persisted for five days. Nine days before admission he was found to have enlargement of cervical, axillar and inguinal lymph nodes bilaterally by his home doctor.
On the 7th hospital day, it became apparent that he had been to “Fuji Speed Way” at the foot of Mt. Fuji eleven days before adrupt rise of temperature, and we found dark reddish crust, “eschar” on medial lower part of his left leg. As tsutsugamushi disease was suspected forthe first time, the sera of his first hospital day were examined for antibody to Rickettsia tsutsugamushi by indirect immunofluorescence. Antibody titer was 1: 20480, indicative of recent infection with tsutsugamushi disease. But Rickettsia tsutsugamushi was not isolated from this patient by intraperitoneal inoculation to mice.
On the 19th hospital day, he was given 2.0 g. of tetracycline daily orally Hehad shown a marked improvement within 2 weeks by this therapy. Two months after onset, antibody titer was 1: 640 and four months and one year later it was 1: 40 respectively. Tsutsugamushi disease at the foot of Mt. Fuji is increasing in recent years according to the reports of Gotenba HealthCenter.
New type of tsutsugamushi disease, “Shichito-netsu” in Izu Shichito islands has not been observed since 1951, but according to the recent reports it is also increasing in Miyake island as well as at other various areas in Japan. We should observe more carefully increasing tsutsugamushi disease from now on.抄録全体を表示PDF形式でダウンロード (549K) -
1979 年 53 巻 8 号 p. 391-393
発行日: 1979/08/20
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (412K)
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