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Predecessor
Volume 26, Issue 7
Displaying 1-4 of 4 articles from this issue
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Michikazu MYOJO1950 Volume 26 Issue 7 Pages 109-121
Published: October 20, 1950
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSWhen thyroxin is injected subcutaneously into male adult rabbits for several days, there is an increase of blood ketone levels. The blood ketone levels begin to increase earlier following the injection of thyroxin and reach the maximum within a few day after the last injection. Thereafter the ketone bodies rapidly decrease to the normal levels. The height of this ketosis is generally low.
By the simultaneous injection of Riboflavin the increase of blood ketone bodies is suppressed.
Also the ketosis in such conditions is remarkably reduced one hour after the injection of Riboflavin. The rate of disappearance of sodium acetoacetate from the blood, injected intravenously into rabbits, is not accelerated by Riboflavin administration.
These results would seem to indicate that the fall of blood ketone levels by Riboflavin administration is due to the prevention of ketone production, but not to the increase of its utilization in extrahepatic tissues.
Further-more Riboflavin has a good effect on the recovery of body weight, but not upon the blood sugar levels, which are slightly elevated.View full abstractDownload PDF (1768K) -
Tadashi MIYAKE, Masahiko SENGOKU1950 Volume 26 Issue 7 Pages 122-132
Published: October 20, 1950
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe urinary 17-ketosteroid excretions were assayed with the ZIMMERMANN's m-dinitrobenzene reaction by a rapid micromethod, modified those of DREKTER et al (1947) and PEARSON et al (1948). As the colorimetric assay procedures were applied to crude neutral urine extracts, the color correction equation of FRASER et al (1941) was used for eliminating the error of overe stimation of ketonic steroids, contributed by other interfering chromogens. The standard crystalline steroids used were ketonic androsterone, dehydroandrosterone, and nonketonic testosterone.
Various precedures introduced by preceding authors for extraction, fractionation, purification, and color formation of the 17-ketosteroids widely reviewed, and clinical availabilities of those were discussed.
The normal values of the 17-ketosteroids excretion of the Japanese people were examined on 66 male and female subjects of various age groups. Average daily excretion of 17-ketosteroids for children under 5 and those 5-12 were 1.33 and 1.9mg., respectively. For males of age groups of 13-16, 17-34, and 35-49, the values were 3.4, 11.9, and 11.0mg., respectively. The second age group was subdivided intö four sections-17-19, 20-24, 25-29, and 30-34. For these four groups of the males the corresponding values were 9.2 11,6, 13.4, and 13.6mg. Average excretion for females of 13-16 and those 17-53 were 3.8 and 9.3mg., respectively. All of the examined 66 subjects were exclusively sound and had no clinical evidence of either endocrine or nonendocrine disorders.View full abstractDownload PDF (1639K) -
Yoshitomi Tokumitsu1950 Volume 26 Issue 7 Pages 133-138
Published: October 20, 1950
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (896K) -
ESPECIALLY ON THE PATHOGENESIS OF ANEMIA CAUSED BY REPEATED INJECTION OF SPLENIC EMULSIONIchiro KUNO1950 Volume 26 Issue 7 Pages 139-158
Published: October 20, 1950
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe pathogenesis of the change of erythrocyte count caused by repeated injection of splenic emulsion is as follows:
1) Spleen produces constantly two kinds of hormone in its venous blood. One of these soluble in ether or alcohol, causes erythropenia and the other, insoluble in them, causes erythrocytosis.
2) When rabbits are injected with a definite amount of splenic emulsion, a slight erythro cytosis occurs, which results from the increase of erythrocytogenous splenic hormone and the decrease of erythropeniogenous one.
3) If this irritation is repeated over 15-20 times with the same quantity, it causes severe anemia on the contray. This anemia results from the increase of erythropeniogenous splenic hormone and the decrease erythrocytogenous one. When the ratio of production of these two active substances are reversed, it can be said to be“aberration of the splenic function.”
4) A severe enduring anemia occurs by injecting the emulsion which is made from the above mentioned aberrated spleen, and this anemia is due to the same mechanism as (3).
As shown in the above experiments, severe anemia can occur even by repeated injection of the normal splenic emulsion.View full abstractDownload PDF (4423K)
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