In order to determine the effects of malnutrition on certain tissues, rats were fed a deficient diet for 15 days. They lost 30% of their weight in this time. Tissue slices were then made from skin, muscle, spleen, liver, kidney, heart and stomach. These were placed in salt solution of varying concentrations (0.5, 0.85, 1.0, 1.5, 2.0%) for 2 hours at 38°C and the degree of swelling determined by increase in weight. Other rats were given various medicines for 10 days (during 15 days semi-starvation) and then their tissues were studied in the same manner. The following results were observed:
1. The swelling ratios of the tissues of semi-starved rats are higher than those of normal rat tissues in any salt,solution.
(Swelling ratio=, where w_o=original wt. of tissue slice and w_t=weight after immersion for 2 hours iu salt solntion (pH 7.0) at 38°C.)
2 This variation is due not only to the amount of water in the tissue, but also to the variation of the molecular swelling capacity of tissue colloid, the osmotic function of the tissue cells, the pH in the cell, and the physico-chemical variation of the blood and tissue fluidwhich is caused by degeneration, probably by inflammatory degeneration of tissue colloid.
3. Every organ has its own curve of degree of swelling in the five different concentrations of salt suetion that I used.
4. We can see the following two kinds of swelling process in organ tissues.
5. In semi-starved rats, there is a certain degree of edema of the skin, but its grade is less than that of other organs, such as the spleen and the liver which are within the body. Swelling capacity is one of the principal causes of edema.
6. The influence of certain medicines upon the swelling ratio, the amount of water in the tissues, and the atrophic ratio of the organs of the semi-starved rat are following (Atrophic ratio=, where w_on=wt. of normal organ and w_os=wt. of organ after starvation)
a,“Koha”(sensitive colouring matter) has scarecely and effect in spite of its popularlty.
b,“Shiko”(another sensitive colouring matter) proves successful, especially in cellular organs (in the case of the liver, the curve becomes almost normal)
c, Vitamin B₁ has considerable effect on the liver, the heart, and the kidney, but on other organs has only a slight effect.
d, Vitamin O has an effect on all the organs which I studied, especially on muscular tissues.
e, Anterior pituitary hormone“Pre-hormone” has an effect on all the organs I studied especially the skin.
d, Thyroxin has no good effect, but even increases the swelling ratio of the organ.
e, Gelatin has an effect only on fibrous tissues.

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In one “hypophysäre Magersucht,” as the substitution therapy was of no effect, an anterior pituitary of a calf was implanted in the retroperitoneal cavity of the patient.
We noticed thereby the increase of body-weight (by 14.0k.g.), disappearance of gastrointestinal complaints, enlargement of corpus uteri, improvement of severe gastroptosis, and normalisation of carbohydrate metabolism.
The remarkable fact was that the patient had the normal menses since the 46 th day of transplantation after two years' abscence, and had twice pregnancies, in which once normol delivery and lactation.
For 5 years she has been in good condition, we believe, therefore, the persistent effect of the transplantation.

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[in Japanese]

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We took the anthropologic corporeal measure according to Ruolf Martin in 57 cases (_??_ 46 cases,_??_ 11 cases) of malnutrition and found the resultes as follows;
1) The stature of malnutrition is small.
2) The face is narrow and small, especially the mandible is poor.
3) The leg is abnormally short, the hand and the foot are slender.
4) The thorax in_??_and the shoulder in are narrow.
5) The emaciation of malnutrition is sever beyond their small stature, especially the extremity is severer than the trunk.
6) The soft tissue rapidly falls into decar with the chang for the worse.
7) In cervical-and humeralregion (belong to C. II.-VIII.), the emaciation is particularly severe from the beginning of the disease.
8) In the emaciation of the upper arm the flexor (belong to C. VI-V.) is severer than the extensor (belong to C. V-VIII.).

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