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Volume 33, Issue 10
Displaying 1-7 of 7 articles from this issue
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[in Japanese], [in Japanese]1958 Volume 33 Issue 10 Pages 849-857
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (1163K) -
III. The Influence of Various Types Treatment upon α-keto acid Metabolism and Acetylating ActivityYukio SHIGETA1958 Volume 33 Issue 10 Pages 858-863,845
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESS1) Insulin had remarkable effect for the improvement of both blood sugar level and oxidative metabolism of carbohydrate.
2) Sulfonylureas were found to be effective for the improvement of fasting blood sugar level, although there were less effective for the improvement of oxidative metabolism of carbohydrate.
3) Cocarboxylase and pantothenic acid improved the oxidative metabolism of carbohydrate and were considered effective as supplementary treatment.View full abstractDownload PDF (727K) -
IV. Pyruvate and Acetate Metabolism in Alloxan Diabetic AnimalsYukio SHIGETA1958 Volume 33 Issue 10 Pages 864-869,845
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESS1) The acetylation in alloxan diabetic rats was decreased markedly in comparison with that in normal rats and was improved by insulin to normal level. The treatment with cocarboxylase and pantothenic acid was also effective to certain extent.
2) The oxidation of pyruvate and acetate in liver homogenate of alloxan diabetic was dacreased remarkably in comparison with that of normal rats and was improved to some extent by the treatment using cocarboxylase, pantothenic acid or insulin.
3) Sulfonylureas, inhibited the acetylation in vivo and in vitro, the oxidation of pyruvate and acetate.View full abstractDownload PDF (793K) -
Experimental pituitary thyroidal tumor according to the hypothalamic factors (1st Report)Takanobu YAMAMOTO1958 Volume 33 Issue 10 Pages 870-887,846
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSFrom the points of view of the relation of hypothalamus to the pituitary-thyroid tumor of the rats according to the hypothalamic factors. The results obtained are as follow:
1) Humoral factor (TRF), which is contained in the hypothalamic and has effective force in increasing the pituitary-thyroidal function, excreated in the urine. Thyroidal weight increased and concentration of PBI augmentated following to the continued injection of TRF intramuscularly or intravenously.
2) Pituitary-thyroid function was inhibited by the shortterm injection of estradiol, in contrast with the stimulating effects of the long-term injection. Estradiol increased the pituitary weights of the rats and made hypertrophy of the pituitary. The effect of estradiol was accelerated in the castrated rats. This seems to be due to the increasing function of ACTH-adrenal system. Inhibitory effects of estradiol to the thyroid function.
MTU Stimulated the pituitary-thyroidal function, mediated by the secretion of TRF and/or directly influencing to the thyroidal gland. Increasing effects of MTU to the thyroidal weights was remarkable in the animals with adrenalectomy, plus MTU, next to the animals with adrenalectomy plus castration plus MTU, and Castration plus MTU followed. Namely, adrenal and gonadal glands acted with inhibiting the increased of the thyroidal weight of the rats by the administration of MTU.
4) Histologicaly, I have examined that the alphacell of the pituitary is related to the increasing effects of estradiol to the pituitary weights and neurosecretory system of the hypothalamus is related to the TSH secretion by MTU.View full abstractDownload PDF (6051K) -
Mamoru MAKINO1958 Volume 33 Issue 10 Pages 888-899,846
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe author observed that hypoglycemia is induced following the injection of autonomic blocking agents to normal and especially to alloxan rabbits, and attempted to elucidate the mechanism of hypoglycemic action of these drugs.
In the present series of experiments, the acute effects of these agents (pentolinium tartarate P-T hexamethonium H-M, tetraethylammonium T-A, benzylimidazoline B-I), chlorpromazine, dihydroergotamine DHE and various hormones on the blood sugar curves of normal, alloxan and adrenalectomized fasted rabbits were studied. The analysis of the blood sugar curves for six hours was done.
The author represented the index of the controlling factors for the activity of carbohydrate regulating hormones, with insulin-effects (I-E) and contrainsulin-effects (C-I-E) (elavating or lowering effect of blood sugar over 10% hourly). And the following results were obtained :
(1) In noamal fasting rabbits, after single injection of such autonomic blocking drugs as P-T, T-A and H-M, there occurred moderate hypoglycemia following initial mild hyperglycemia, and in these blood sugar curves the author found that there are such specific factors as initial and final C-I-E with median I-E between them.
(2) The effects of three hormones (insulin, ACTH and cortisone) on the blood sugar curves of normal rabbits were represented with initial I-E, but only adrenalin induced hyperglycemia and expressed initial C-I-E with final I-E.
(3) Alloxan-diabetic rabbits usually responded with severer hypoglycemia than that of normal rabbits following injections of all autonomic nervous blocking drugs and various hormones, and never appeared C-I-E factors in blood glucose curves after these injections except B-1 and ACTH.
(4) In the normal rabbits injected P-T with insulin, ACTH or cortisone, the action of P-T were not appeared both on the blood sugar curves and on the effects of these hormones, however in cases injected P-T with adrenalin, P-T occurred marked effect and there could be seen no more hyperglycemic curve and C-I-E factors.
(5) In adrenalectomized rabbits, in which the levels of the fasting blood sugar are low, hyperglycemic curves were never induced following in jection of P-T, and C-I-E factors were never observed following injection of P-T or ACTH, similarly to normal rabbits injected adrenelin with P-T.
(6) The hypoglycemic action of P-T appeared severer in alloxan-diabetic rabbits with reduced islet function than in normal ones, and in alloxan rabbits no effects were observed on ACTH blood sugar curve by P-T injection, however this agent caused marked effect on adrenalin curve ; the hyperglycemia in these rabbits turned over hypoglycemia and no more C-I-E factors were seen.
From these observations therefore the acute hypoglycemic effect of P-T seemed to be the effect of diminished activity of C-I-E groups of hormone, especially that of adrenal factor.View full abstractDownload PDF (1677K) -
Haruhiro ANDO, Kinichi HIROSE1958 Volume 33 Issue 10 Pages 900-904,847
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSOn the abject of knowing the function of adrenal cortex, we have examined a few Points in the method for the determination of 17-Ketostosteroids (abbreviated 17-KS).
In summation: 1. The condition for hpdrolysis of rat urine, 10ml of concentrated hydrochloric acid is added to 5ml of urine and let it stand for thirty mimites.
2. In order to absorb chromogens, it is better not to use absorbent carbon powder, because it will a considerable amount of 17-KS too.
3. The best conditions for developing color, the following condition is used, namely: aqueous 5N potassium hydroxide, at 25°C, and leaving 110 minutes for reaetion.
4. The value of non-ketone fraction is remarkable high in Rat urine. Therefore in case of Rat urine, non-ketone fraction is to remove by Girard treatment in each sample.
5. The amount of excretion of 17-KS in adult rats is between 52.5-39.7μg in males, and 19.9-32.6μg in females.View full abstractDownload PDF (678K) -
1958 Volume 33 Issue 10 Pages 905-925
Published: January 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (2988K)
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