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Volume 34, Issue 6
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1958 Volume 34 Issue 6 Pages 514-525
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (1194K) -
[in Japanese]1958 Volume 34 Issue 6 Pages 526-530
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
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Sadamu DOHI1958 Volume 34 Issue 6 Pages 531-534,509
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSBy seminal vesicle and prostata weighing test (Fevold) was performed, and the results were as follows : Testosterone suspension and oil solution had short acting effects, and in 5 days after administration, it showed the maximum effects, but durated no longer.
On the contrally, testosterone β-cyclopentyl propionate had no short acting effects. But its effects w ere strong and maximum effects were 2 times or more greater than that of testosterone or testosterone propionate and durated for l month or more after the administration.View full abstractDownload PDF (411K) -
Sadamu DOHI1958 Volume 34 Issue 6 Pages 535-539,509
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESS(1) By means of seminal vesicles and prostata weighing test (Fevold), we investigated the co-operative functions of androgen and estrogen mixture agents day by day.
By changing their ratio and dosis, some interesting results were obtained.
Maximum co-operative effects were observed under following conditions :
i.e. By 5 mg. and 2.5mg., testosterone to estrogen ratio was 30 to l. By 1.25mg., the ratio was 20 to l.
(2) According to the rise of estrogen level, the peak of maximum effects shifted to the right and aslo became uneffective.
As above mentioned, when the androgenic effects were wanted in administration of mixture hormone, estrogen ratio to androgen might not be too great.View full abstractDownload PDF (581K) -
Keishi MATSUMOTO1958 Volume 34 Issue 6 Pages 540-555,509
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe chemical assay of urine pregnanediol, estriol, estradiol and estrone of 25 pregnant women 3 to 5 days before parturition 8 women of 7 months pregnancy, 5 women of 6 months pregnancy and 5 women of 5 months pregnancy, together with the histological and histochemical studies of the placenta was carried out with the following results. The Stimmel method (1952) was used for the quantitative analysis and the Sudan, Schiff, Ashbel-Seligman and Schultz stain was used for the histochemical studies.
I) Up to the fifth to sixth month of pregnancy, all the syncytial cells have the ability to secrete progesterone and estrogen, but from the seventh month the general syncytial cells start to loose this ability and by the tenth month ability to secrete steroids is lost with only the knobs of nucleated syncytium retaining this function. This view is based on the following facts.
1) In the fifth and sixth month of pregnancy, both the general syncytial cells and the knobs of nucleated syncytium show no degeneration and are positive to carbonyl stain. 2) The general syncytium, from the seventh to thnth month of pregnancy, shows a progessive degeneration and is negative to carbonyl stain. 3) The knob of nucleated syncytium through the seventh to tenth month shows no histological changes from the fifth month, and remains positive to carbonyl strain. 4) The per unit progesterone and estrogen secretion of the syncytial cells decreases with the progress of pregnancy. 5) The knobs of nucleated syncytium increase toward the termination of pregnancy. 6) The knobs of nucleated syncytium in the tenth month placenta and the unit placenta weight 24 hour urine pregnanediol and estrogen have correlation coefficent of 0.68 and 0.39, thereby sho wing a correlation.
II) The weight of the tenth month placenta and the 24 hour urine pregnanediol show a correlation coefficient of 0.58, and the 24 hour urine estrogen 0.48, thereby showing a correlation.View full abstractDownload PDF (4440K) -
Kaizo KOBAYASHI, Fumio KUZUYA, Takayoshi FUJII, Tuneji KUNO1958 Volume 34 Issue 6 Pages 556-563,510
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSSince the beginning of the latter half of this century, we have received many reports on the electron microscopic structures of renal glomerulus and tubules ; but not on what Goormaghtigh called “Juxtaglomerular Apparatus, ” except that on the unusual cells of which Braunsteiner and others described under the title of Juxtaglomerular cells.
According to our observations, in a rat's kidney, there exist such cells as have endoplasmic reticulum around the- nuclei and have mitochondria dotted in 2he cytoplasma, which look like the ones Braunsteiner and others mentioned.
Judging from their forms, we thought we could conclude that these cells work internal secretion producing renin and other substances.
Besides, we found another kind of cells, in the interstitium of the cortex, which has the cell membrane, and round dense bodies, presumably produced in many small vesicles in its cytoplasma, and we also concluded, from the morphological view-point, that this kind of cells might work some internal secretion too. All these make us think of the need of further inquiry, morphological and functional, about such cells as were mentioned above.View full abstractDownload PDF (3356K) -
Kazuo YAMASHIRO, Toshihiko HASHIMOTO, Hiroshi KOIZUMI, Kazuya WAIMATSU ...1958 Volume 34 Issue 6 Pages 564-571,511
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIn an attempt to study the intermediary metabolism of carbohydrate in diabetic patients, the authors measured the blood glucose, pyruvic acid, lactic acid and inorganic phosphate following the administration of glucose (22 cases intravenously and 19 cases orally), and the following results were obtained ;
1. From the results of blood glucose and inorganic phosphate following the administration of glucose, the process of phosphorylation in the blood is almost inhibited in diabetic patients compared to the healthy persons and a marked depression of this process were found in severe cases of diabetics.
Following the administration of glucose, the significant high blood lactic acid levels of severe cases of diabetic patients were lowered; acommpanying with rised pyruvic acid in the blood, while in the mild and moderate diabetic patients the increased blood lactic acid with no change of blood pyruvate were seen.
It is clear from these results that a definite different response to intermediary carbohydrate metabolism following the administration of glucose may have been occured in the severe diabetic patients compared with those of mild diabetic patients or healthy persons.View full abstractDownload PDF (1108K) -
Ryuji NAKADE1958 Volume 34 Issue 6 Pages 572-577,511
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIn a previous paper, the author reported on the plasma levels of adrenocortical hormones in rats poisoned with various metals such as Ag, Au, Bi, Ca, Cu, Fe, Hg, Mg, Mn, Pt, Sb and Zn. Among the metals studied, only gold was found to stimulate the pituitary-adrenal system and to elevate the plasma levels of corticosterone and the corticosterone content of the adrenal glands.
In the present report, the influence of the gold preparation, Solganal B oleosum, on the pituitaryadrenal system of human subjects was studied. The plasma level of hydrocortisone and the urinary excretion of 17-hydroxycorticosteroids were determined before and after the administration of small doses of Solganal B oleosum and the following results were obtained :
1. Administration of small doses of Solganal B oleosum to human subjects markedly elevated the plasma level of hydrocortisone and increased the urinary excretion of 17-OHCS.
2. It would be reasonable to consider that administration of a gold salt stimulates the pituitary-adrenal system.View full abstractDownload PDF (949K) -
Mitsuo ITO, Yukimasa HIRATA1958 Volume 34 Issue 6 Pages 578-582,512
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIt is frequently encountered that the serum of the rabbits with experimental diabetes become turbid or chylous. It is known that in these rabbits the concentrations of total cholesterol, total and neutral fats are exceedingly high. A study was undertaken to investigate the effect of glucagon on the severe lipemia in rabbits with experimental diabetes, and the following results were obtained :
(1) Approximately seven-fold increase in serum cholesterol was observed by a single injection of dithizone alone whereas the increase was only three-fold in animals received daily injections of 20-30γ /kg. of PVP-glucagon following dithizone injection. When the dose of glucagon was increased to 120γ /kg in the same animals, no further increase in serum total cholesterol occured and even transient decrease was observed. Turbidity of the serum in these animals paralleled to the change of serum cholesterol.
(2) Intravenous administration of 400γ /kg of glucagon 10 minutes prior to the alloxan injection appeared to prevent the diabetes produced by alloxane. However, in a rabbit received 200γ/kg of glucagon intravenously 10 minutes prior to dithizone injection development of diabetes was observed. The increase of serum total cholesterol in these animals was none or less marked as compared with that of control animals, and the serum remained clear.View full abstractDownload PDF (483K) -
III. Influence of Various Types of Treatment on the Metabolism of Ketone Bodies in Alloxan Diabetic RatsTakeshi MORIWAKI1958 Volume 34 Issue 6 Pages 583-588,512
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSAs previously reported, the urinary content of ketone bodies reflects the condition of diabetics, even in those with negative qualitative test for ketone bodies. In order to elucidate the diabetic ketosis more precisely, urinary content of ketone bodies were measured quantitatively and hepatic formation of ketone bodies were measured in liver slices of alloxan diabetic rats, and the effect of treatment using insulin, sulfonylurea, mesoxalate and various types of vitamines were studied, and following results were obtained.
1. In alloxan diabetic rats, after treatment using insulin, mesoxalate, pantothenic acid or cocarboxylase, urinary excretion of ketone bodies decreased, although sulfonylurease did not show remarkable changes.
2. In addition insulin and mesoxalate added to the medium of incubation caused decrease in ketone bodies formation of liver slices of alloxan diabetic rats.
3. After treatment using insulin, mesoxalate, pantothenic acid or cocarboxylase, ketone body formation of liver slices was decreased, although sulfonylureas did not show such effect.
4. In high fat diet, urinary content of ketone bodies and ketone body formation of liver slices were found to be increased in comparison with that in high carbohydrate or high protein diet.View full abstractDownload PDF (788K) -
1958 Volume 34 Issue 6 Pages 589-597
Published: September 20, 1958
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (1253K)
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