Folia Endocrinologica Japonica

SOME INFORMATIONS ON DIABETES MELLITUS AFTER CAUDAL RESECTION OF THE PANCREAS IN A GENUINE EPILEPTIC

Shunji TOKUOKA

1951 Volume 26 Issue 12 Pages 335-340
Published: March 20, 1951
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.26.12_335

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In our 28 epileptics hyperglycemia after the partial resection of the pancreas (caudal 3/5 of the entire organ) as a. cure for genuine epilepsy returned to the normal level mostly 2-3 weeks after the operation, but in only one case there was a persisting diabetes mellitus, where caudal 4/5 was resected. From our clinical results it may be conceivable that diabeltes mellitus after this operation should be prevanted by the protection of the islets by means of alimentotherapy, if the functions of the pituitary, adrenal or thyroid glands are normal. In this diabetic case the x-radiation on the pituitary gland and the superior cervical sympathetic ganglionectomy resulted in the decrease of the sugar level of blood or urine, and also the administration of estrogen resulted in the obvious decrease of blood sugar level if the pituitary gland not so much atrophied.

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URINARY 17-KETOSTEROIDS IN CHILDHOOD AND THE SIGNIFICANCE OF INDIVIDUAL VARIATION OF THESE EXCRETIONS

Toshitaka ISHII

1951 Volume 26 Issue 12 Pages 341-348
Published: March 20, 1951
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.26.12_341

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Being interested in the broad-ranged individual variation of excretory 17-ketosteroids (17-kS) in urine on persons less than 10 years of age whose 17-KS are almost regarded as those derived from the adrenal cortex, I examined these daily excretions in urine of 22 normal and healthy children of aged from 6 years 9 months to 7 years 10 months (aver. 7 years 4 months) and, made a consideration about their individual variation.
1) measured 17-KS by the modified Holtorff-Koch's method with dehydro-iso-androsterone as standard.
2) The values of daily excretions in urines of these substances ranged from 1.4mg to 6.5mg (mean, 3.7mg: 3.2mg≤M≤4.2mg, α=0.05) in this age.
3) The extent of age of 14 months did not display a significant variation in these 22 cases.
4) The difference between boys and girls could also not be found.
5) I divided these children into two groups by the table of testing diathetic tendency used in our department. One group consists of those individuals whose bodies are more sensitive to various stimuli, and the other consists of those individuals whose bodies are not so sensitive, then I found significant lower values of 17-KS excretions in the former group.
According to the Sayers and Sayers' theory in which PERIPHERAL-HUMORAL-MECHANISM of homeostasis between ACTH and adrenocortical hormone plays a greater part in the PITUITARY ADRENAL SYSTEM, it could be said that individuals possessing fewer cortical hormones will deplete greater parts of these hormones and will induce larger proportions of ACTH from the pituitary under various kinds of stressful conditions, if surmised that the same quantities of cortical hormones in the tissue cells are utilized by the same quantities of stimuli. In other words, those individuals will produce the alarm reactions (Selye) more easily and more severely.
It may be of interest that individual variation of adrenal cortical hormones in bodies would indicate the degree of individual response to stimuli.

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EXPERIMENTAL RESEARCH FOR EFFECTS OF SKIN IRRITATION ON ORGANISM FUNCTIONING TO MAKE IMMUNBODIES AND ITS REVEALINGS MECHANISM

Fifth report: The summary of all reports

Ataru ADACHI

1951 Volume 26 Issue 12 Pages 349-360
Published: March 20, 1951
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.26.12_349

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1) The skin irritations cause the two kinds of different effects on the function of immunbody production, according the degree of irritations applied on the skin, in other words, one is accelerative, the other obstructive.
The kind of skin irritation that will increase the number of the blood platelets acts acceleratively on the function of immunbody production, and that which increase simply the number of blood leucocytes no effects on it.
2) The mechanism of these effects is supposed to be due to the humoral transmitting, that is, the certain specific substances produced in the skin by the skin irritation are led into the blood stream and then cause the influences on them.
The accelerative effects on the function of immunbody production are not due to the direct action of the certain specific substances, but it gives some influences on the thyloid gland and spleen predominatel and only through them it gives the above stated effects on the function of immunbody production secondary.
3) The certain substances produced in the skin by the irritations which give beneficial effects on the body are identical with the skin hormone or so-called “Esophylaxin”, whereas, that which is produced by the stronger irritation and acts badly is supposed to be a kind of tissue toxin.

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EXPERIMENTAL RESEARCH FOR EFFECTS OF SKIN IRRITATION ON ORGANISM FUNCTIONING TO MAKE IMMUNBODIES AND ITS REVEALINGS MECHANISM

Fourth report. On the relationship between the effects of the skin irritation and the serum of dermatitis rabbits upon the function to produce immunbodies, further on the skin specifity of the certain

Ataru ADACHI

1951 Volume 26 Issue 12 Pages 361-372
Published: March 20, 1951
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.26.12_361

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This is to clearfy that the mechanism of two kind of effects, one is accelerative, the other obstructive, on the function of the immunbody production is whether due to the humoral trasmitting or to the nervous transmitting.
It is experimented the influences upon the function to produce immunbodies with the both. rabbits serum after the application of such irritations as to produce the immunbody acceleratively and obstructively. Further, for the purpose of clearfication of the skin specifity of the certain substance which give accelerative effects on the function of immumbody production by the skin irritation, the various kind of irritations which caused the accelerative and obstructive effects on the function of immunbody production.
The results of this experiment are summarised followingly:
1) The mechanism of the accelerative and obstructive effects on the function of immunbody production by the skin irritations is due to the humoral transmitting.
2) The certain substances produced in the skih by the irritations which give two opposite effects on the function of immunbody production are definitely different in their quality.
3) The certain substances which give the accelerative effects on the function of immunbody production are produced only in the skin tissue. (For this meaning, the term of “skin specifity” is applied here.)

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