Folia Endocrinologica Japonica

In this repot we investigated the influences upon the acid-base equilibrium of the adrenalectomized white rabbit.
The right adrenal gland was first removed from the animal and one to two weeks allowed to elapse before the left gland was exstirpated.
Blood was drawn from the auricular vein or the jugular and femoral artery.
Total bicarbonate content determinations of the blood and urine were made according to the Van Slyke technique.
pH determination was made by the glass electrode.
Titratable acidity of the urine was determined by the 0.1N sodium hydroxide with indicator of neutral red.
Urine ammonia content was determined by the Conway's apparatus.
The results run as follows.
1) There is always a fall in pH of blood and urine following adrenalectomy.
2) Bicarbonate content of the blood and urine always decreased.
3) Urine ammonia and titratable acid content increased following adrenalectomy.
4) These results indicate a metabolic type of acidosis, and this acidosis will be more increased by renal failure.

View full abstract

Show abstractHide abstract

The effect of hormone upon our vital process is very complex and subtle. On its functionary process many investigations have been tried one of these days, but, as to its minute details, they are still left unclarified. As might be well conjectured, inorganic elements, in particular, might be playing a delicate role in it, to have the circumstance clarified, we have investigated on it, experirhenting, out of 86 subjects, upon hypophysis-69 cases, Pancrease-79 cases, thyroid-80 cases, Adrenal gland-77 cases, testicles-47 cases, ovarium-27 cases, thymus-32 cases, glandulae parathyreoideae-5 casef, with placenta-14 cases inclusively-upon 430 case in all. Together with the measurement of the amounts of water and of cinerary matter in each endocrine organ, 24 inorganic elements in alt the test-materials (Ag. Al. As. B. Ba. Bc. Ca. Co. Cu. Fe. K. Mg. Mn. Na. Ni. P. Pb. Si. Sn. Sr. Ti. V. Zn.) were systematically investigated as contrasts.
Interesting results were obtained as to the cause of death of an individual, and distinctions of disease, of sex, and of age, as following:
If the elements, Mn, in particular, in reference to hypophysis, has been presumed to be an important element, dominating the activities, of growth and generation. Our experiment has confirmed the presumption. Of Zn, again, interesting works on it have been made public lately, and we have also confirmed the fact that it has an important significance in the growth of a living body, and a certain definite reference to the generative activity as well as Mn, but Zn differs from Mn in being fairly rich in the pancreas which affirms its close relationship with insulin.
Further, of Al, Ni, Ca, Ag, Cu. etc., we could add some new, appreciating infarmations on them which might, we believe, shed a light on the field of hormone.

View full abstract

Download PDF (5831K)

Register with J-STAGE for free!