This is a case that had led us to diagnose it clinically as carcino-peritonitis due to metastasia of rectal cancer, revealing a peculiar image of cells in May-Giemsa staining as well as in phasecontrast microscopic findings and proved to be the peritonitis that had occurred in succession to Disgerminom of the ovary, only after pathological dissection was held. The cells of the tumor reacted to Nitromin well, manifesting very interresting findings. The patient was a female aged 55, the oldest one among the cases that had ever been reported. As to the secondary sexual symptoms, they were considered to be of the Klaften's 3rd type.

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Studies were undertaken to compare the relative merits of the double sugar tolerance test on 51 diabetic patients. This is a report of the series of tests, namely, the intravenous method which consists of 50% dextrose 40 cc. injected intravenously and the amount repeated one hour later; and the oral method which consists of 50 gm. dextrose orally administered and followed by the equal amount two hours later to be done on the same patient under the similar carbohydrate metabolic state.
1. With Staub-Effect (S-E) the both of methods agreed in most instances (70%), while the disagreement was noted in the smaller number of cases (20%). The cases of disagreement were all mild or moderately advanced cases, the majority of them showed negative with the intravenous method and positive with the oral method. There was a definite agreement of S-E pictures in either method in far advanced or advanced cases. The reason for the disagreement of S-E in both of the methods and with Kajiyama's experimental result as well as the clinical manifestation was perhaps due to the difference in time interval of the double sugar tolerance.
2. There was hardly no change to be seen between the healthy persons and the mild cases when both methods have been compared as to the quantity of urinary sugar excretion: however, with the cases of moderately or advanced, the intravenous method showed lowered urinary sugar excretion (17%-27%) in general than the oral method instituted.
3. When there occured profound difference noted between the oral and the intravenous method on the blood sugar curve, the cases will be designated as a group with specific functional derangement of sugar utilization, and a basic standard conditions necessary for the selection was prepared for these cases. It was found that the cases which met the standard basing on the respective finding numbered 14 selected cases among 51 diabetic patients.
4. The following characteristic findings were observed in these cases of the specific functional derangement of sugar utilization.
(a) 12 cases out of the above 14 patients had showed high degree of functional derangement in sugar utilization in the sugar tolerance with the oral administration method than the intravenous method.
(b) The group comprised of all degree of blood sugar tolerance curve from mild ones to advanced.
(c) Since these cases were considered to be abnormally insulin sensitive in most instances, it is reasonably assumed that these patients may have possessed with socalled extra-pancreatic factors as these patients respond little with regular insulin therapy and show less therapeutic efficacy.

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In order to deciding the subjects of diabetogenic or antidiabetogenic action of the pituitary and adrenocortical hormones, it should be important to confirm the action on ketosis of these hormones. These has been but little information available regarding on this problem and also the effects of these hormones on ketogenic activity are reported with conflicting results.
The present investigation is undertaken to determine the changes of blood ketone bodies of alloxan diabetic rabbits or dogs after single injection of ACTH with or without butyrate and single injection of cortisone or DOCA, and also to find the effects of these hormones by their daily administration for a prolonged period.
The following results have been obtained.
I. Ketogenic activity of ACTH for alloxan diabetic rabbits.
(1) In normal rabbits increase of the total ketone bodies in blood following the injection of ACTH was extremely small, however in alloxan diabetic rabbits, the total blood ketone bodies showed particular elevation of β-hydroxybutyric acid, and the increase was somewhat pronounced.
(2) With the animals injected of sodium butyrate, the ketogenic influence reaches well marked degree and lasting a longer hours in alloxan diabetic rabbits in contrast to the healthy ones. While, a rise of acetone was almost parallel with β-hydroxybutyric acid in healthy animals, b It with the alloxan rabbits β-hydroxybutyric acid rose markedly and was followed with gradual depletion.
(3) When ACTH was injected into rabbits of exogenous ketosis due to sodinm butyrate, the degree of ketosis became more pronounced either in normal or in alloxan animals than when sodium butyrate was given alone, especially, the elevation of β-hydroxybutyric acid was definitely marked. II Ketogenic activity of pituitary adrenocortical hormones for alloxan diabetic dogs.
(1) When ACTH was administered for alloxan diabetic dog, the total blood ketone bodies increased markedly and both acetone and β-hydroxybutyric acid reached the maximum levels after one hour, and the former showed rapid depletion, while the latter showed gradual lowering.

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