Folia Endocrinologica Japonica
Online ISSN : 2186-506X
Print ISSN : 0029-0661
ISSN-L : 0029-0661
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Volume 29, Issue 9-10
Displaying 1-4 of 4 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1954 Volume 29 Issue 9-10 Pages 217-223
    Published: January 20, 1954
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.1507/endocrine1927.29.9-10_217
    JOURNAL FREE ACCESS
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  • Studies on the diabetogenic chemical substance
    Tokuyoshi ABE
    1954 Volume 29 Issue 9-10 Pages 224-252_1,267
    Published: January 20, 1954
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.1507/endocrine1927.29.9-10_224
    JOURNAL FREE ACCESS
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    1) Numerous studies on diabetogenic action of organic reagents have been made since discovery of the oxine and dithizone diabetes. But, it is necessary to find other active agents and to examin their action precisely in order to reneal the acting mechanis of these diabetogenic agents.
    Therefore, present studies on diabetogenic action and histological changes in islet of Langerhans in rabbits caused by potassium ethylxanthate and quinoline derinatines have been under taken.
    2) All rabbits injected with potassium ethylxanthate showed initial hyperglycemia and subsequent hypoglycemia in 50 persent, from which they are irreconerable despite of administrating glucose and epinephrine.
    About thirty per cent of rabbits, which did not show marked hypoglycemia, then, showed diabetic state after forty-eight hours.
    By repeated daily injection from four to twenty times of potassium ethylxanthate, slight hyperglycemia and diabetic state were observed.
    By injection of potassium ethylxanthate, a alloxan-diabetic rabbit died from hypoglycemia after 3 days.
    3) Out of thirteen quinoline derivationes, 5 aminooxine and 8-hydroxy quinaldine were observed to cause marked changes in blood sugar with dostruction of islet of Langerhans.
    By 5 aminooxine initial hyperglycemia followed by subsequent hypoglycemia or normal lenel of blood sugar and then diabetic state were observed from 48 hours to 5-7 days.
    By 8-hydroxy-quinaldine initial hyperglycemia followed by slight hypoglycemia and secorndary hyperglycemia, permanent diabetes were noted.
    4) Histological studies of rabbit injected with 5-aminooxine and 8-hydroxy quinoline could reneal remarkable changes in islets of Langerhans in pankreas.
    Degenerative changes of beta cells of islets in early stage and senere necrosis and disintegration in hypoglyceinie stage were observed.
    In diabetic stadium, islets were reduced in number and size and were chiefly composed of alpha cells.
    In rabbits in hypoglycemic state caused by potassium ethylxanthate, degenerative changes in nerve cell in brain were observed. No remarkoble damages were noted in other tissues.
    5) Histochemical study demonstrated no glycogen in tissues from hypoglycemic animals.
    6) Close correlation between diabetogenic action and chemical stuructures were established in quinoline derivatives.
    A Hydroxy group in position 8 of quinoline was essential for destructing action on islet tissues.
    Increase of hydroxy and carboxyl groups dimishen their toxicity remarkably and abolished the specific action despite of hydroxy group in position 8.
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  • Splenic Enlargement Induced by Thymus Feeding in Adult Rats
    Masasuke MASUDA, Koichi IMABAYASHI
    1954 Volume 29 Issue 9-10 Pages 253-358,268
    Published: January 20, 1954
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.1507/endocrine1927.29.9-10_253
    JOURNAL FREE ACCESS
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    1) The feeding of thymus of calves in rats over a period of 60 days resulted in a development of a moderate splenomegaly.
    2) Anemia, leukopenia and thrombocytopenia with splenomegaly were observed in the different combined form in the different rats and hyperplasia and maturation asynchronism of bone marrow were found in all cases.
    3) On the histological features of these splenomegaly revealed that reticulum cells lining sinusoid, were remarkably thickened and showed hyperplasia and definite phagocytic activity with hemosiderosis in all cases.
    4) In these rats, splenectomy seems to prevent the development. of anemia and leukopenia.
    5) Judging from above findings, it is suggested that this splenomegaly should be related so-called “Primary Hypersplenism”.
    6) Fuather experiments are being carried out to determine the actual substaUce present in the extract of the thymus which causes the enlargement of the spleens, and the influence of splenctomy.
    7) It is suggested that the splenomegaly produced by thymus feeding may represent an experimental form of the process to which, in man, the term “Primary Hypersplenism” has applied.
    The authers wish to express their deep indebteness to our respected Prof. G. Kawai of Department of Medicine at Kyoto Pref. University of Medicine for his interest and guidance.
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  • The insulin Test of the Splenomegaly and the Place of the Splenomegaly in the Endocrine System
    Masasuke MASUDA, Norio FUJIKI, Tatsuro TAKINO
    1954 Volume 29 Issue 9-10 Pages 259-266_3,268
    Published: January 20, 1954
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.1507/endocrine1927.29.9-10_259
    JOURNAL FREE ACCESS
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    [in Japanese]
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