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Volume 39, Issue 10
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1964 Volume 39 Issue 10 Pages 897-953
Published: January 20, 1964
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (7855K) -
Mitsunori UTOSAWA1964 Volume 39 Issue 10 Pages 954-982,893
Published: January 20, 1964
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPart I. Fundamental Studies on the Determination of thyrotropin (TSH) using McKenzie's method.
Male and female SM strain mice (15-17Gm) were used as assay animals. It was found convenient to use a 4 point assay technique with 6 observations for each of 2 doses of the standard thyrotropin and the unknown preparation. Thus with a total of 24 mice.
The range of linear responsiveness was 0.05 to 0.4mU (Y=90.9X +81.5) and the index of precision (λ) was 0.35. (5=31.5, b=90.9) The smallest amount of thyrotropin detected by this technique was 0.025mU. The recovery was 95 per ceut from the serum of normal subject.
Part II. Bio-assay of thyrotropin (TSH) in human blood
1) The average concentration of TSH in the serum of 17 normal subjects was 0.107 (0.053-0.177) mU per ml and in 2 normal subjects, serum TSH could not be detected by this method.
2) The average concentration of TSH in the serum of 14 primary hypothyroidism was 0.365 (0.207-0.989) mU per ml. On the contrary, in 2 secondary hypothyroidism, serum TSH could not be detected by this method.
3) The average concentration of TSH in the serum of 18 hyperthyroidism was 0.228 (0.066-1.062) mU per ml and in 3 hyperthyroidism, serum TSH could not be detected. The TSH concentration in the sera of hyperthyroidism was greater than in normal subjects but smaller than in primary hypothyroidism. The TSH concentration of hyperthyroidism with exophthalmos was slighty greater than without exophthalmos, but no abnormal high level.
4) The TSH concentration in the sera of simple goitre was within the range of normal subjects and in Hashimoto's disease, postoperative thyroid cancer and subacute thyroiditis was slightly higher than in normal subjects. In acromegaly and Simmonds' diseasease, serum TSH could not be detected. In Cushing's syndrome and Addison's disease a definite tendency of serum TSH could not be found.
Part III. The clinical studies on the abnormal thyroid stimulator (abnormal TSH) of hyperthyroidism.
The abnormal TSH of hyperthyroidism was distinguished from the standard thyrotropin by its prolonged action in an assay for thyrotropin. Using mice previously injected with I131, a maximal increase in circulating radioactivity occured 2-3 hrs. after the intravenous injection of standard thyrotropin, normal human serum or whole serum from patients with myxedema. The injection of serum from patients with hyperthyroidism, hoverer, produced maximal increase in the circulating I131 only after 9-12 hrs.
1) The abnormal TSH was sought in the serum of 94 persons and was found in (a) 21 of 30 persons with uutreated hyperthyroidism, 20 of 29 persons with hyperthyroidism after I131 therapy and 5 of 14 persons with hyperthyroidism after antithyroid medications ; (b) 2 of 9 normal subjects ; (c) 1 of 2 persons with subacute thyroiditis.
2) The level of the abnormal TSH showed a falling tendency after treatments. (I131 therapy and antithyroid medications)
3) No specific correlation was found between clinical symptoms and the level of the abnormal TSH of hyperthyroidism.
4) No correlation was found between the presence of exophthalmos of hyperthyroidism and the level of the abnormal TSH.View full abstractDownload PDF (3184K) -
S. KIJIMA, Y. KITAURA, T. IGARASHI1964 Volume 39 Issue 10 Pages 983-987,895
Published: January 20, 1964
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSA case is reported of a 42-year-old woman dying of complicated diabetes mellitus. In an attempt to study the pathological changes in the anterior lobe of the hypophysis on serial section, two areas of necrosis were found, in which one was round and the other was wedge-shaped. The former was 1.0mm. in diameter and the other was 1.5mm. in length. It is conceivable that these are too small to exert any effect on the pituitary function. While the cause is unknown there is good reason to suspect that the necrosis is of ischemic origin in relation to arteriosclerosis.View full abstractDownload PDF (1703K) -
Kin-ichi HORII1964 Volume 39 Issue 10 Pages 988-995,896
Published: January 20, 1964
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSUnpedigreed virgin white mice of the Watanabe colony bred in this laboratory for a year and a half were used as experimental animals. Eighty mg of alloxan per kg body weight was given intravenously to the test group as well as the control on the 11 th day of gestation. The test group was treated 7 times with 0.4 units of “lente insulin” at 12-hour intervals from 36 hours after the alloxan injection, up to the 15th day of gestation. The dose of insulin incured no risk of hypoglycemia in diabetic mice, but was not necessarily enough to lower the elevated blood sugar levels to normal, in about half of all instances. Pregnant mice of both groups were sacrificed on the 19th day post coitum, and fetuses were removed by laparotomy and examined for externally visible defects.
No fetus with gross anomalies existed in 407 born to 40 successful pregnant mice in the test group. In the control group treated by alloxan alone, on the other hand, there were 9 pregnancies which had more than one malformed fetus out of 40 successful ones (22.5 per cent) and 25 fetuses with cleft palate out of 369 live-born (6.8 per cent). The term, “successful pregnancy”, is regarded as a pregnant mother having more than one live fetus found at laparotomy on the 19th day of gestation.
An increase of the body weight due to pregnancy was less in mothers with malformed fetuses than in those with normal fetuses ; this difference being statistically significant by means of the chi-square test with the probability level of 0.02, whereas no appreciable difference was found between blood sugar levels in the two categories of mothers.View full abstractDownload PDF (1653K)
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