Aiming at the search of the method for the appraisal of the labour strains in the actual industrial labour, 124 representative workers of a factory were measured for the intensity of their principal work and the values of the work-amount during their working hours. Simultaneously, the patterns of the changes in the flicker values as well as the numbers of the circulating eosinophils during the working hours of the same workers were observed by time lapse. The outline of the results thus obtained are as follows:
(1) The tendency connecting the upper limits of the values of the work-amount and the fluctuating amount of the flicker values during the working hours against the intensity of work of each principal work indicated patterns which are contradicting each other.
(2) The rate of fluctuation in the number of circulating eosinophils did not demonstrate any fixed correlation with the value of work-amount during the working hours. However, its uppermost value demonstrated a tendency of reduction when the mean temperature exposed during the working hours. rose similarly to the case of the value of work-amount during the working hours.
(3) In the actual works in such a factory as that under the present investigation, the value of the work-amount during the working hours, the fluctuation in the flicker value and the number of the circulating eosinophils demonstrate tendencies to represent the muscular labour strain, mental labour strain and environmental labour strain respectively. Therefore, if indices of the labour strains of the workers engaged in various kinds of works are sought by combining these 3 indicators with a same weight, the approximate labour strain might be able to be estimated with these indices.

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Considering that the galvanic skin resistance, which is believed to indicate sensitively the central excitation or the functions of sympathetic nerves, should be kept openn for further studies as one of the indicators of the labour strain, the authors investigated the patterns of changes in the galvanic skin resistance by time lapse in the static and in the active working state. The results thus obtained are roughly as follows :
(1) The galvanic skin current in the static state showed a relatively larger diversion compared with the puls rate, skin temperature etc. However, it never showed any fixed correlation with skin temperature, puls rate, sex, age, fat or slender.
(2) The absolute value of the galvanic skin current in the active working state demonstrated a tendency of reduction as the intensity of work becomes higher. However, in the observation of its changes by time lapse, a tendency of reduction was usually observed when the intensity of work was lower than the limit of the establishment of a steady state, and a tendency of gradual increase was usually observed when the intensity of work was higher than the limit. Furthermore, a tendency that the rate of increment. of the galvanic skin current in such cases well indicate the labour strain.
(3) The demonstration of the distress induced by a static work or the labour strain with the galvanic skin current is considered inadequate.

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It has long been well known that a highly potent hemotoxin is obtainable by shaking for a short period of time the bacterial bodies of hemolytic streptococcus suspended in blood serum. The hemotoxin thus obtainable was named “Weld's hemotoxin.” However, no details as to the production mechanisms and production factors have ever been elucidated as yet. Meanwhile, the fact that even more highly potent hemotoxin is obtainable when solution of nucleic acid is employed in stead of blood serum has been found by Hosoya, Egami and Hayashi. Anticipating that the reality of the production factors in the blood serum might be consisting of the minute amount of nucleic acid contained in the serum, the authors fractionated blood serum following Schneider's method, and the hemotoxin production capacity of each fraction was investigated. As the results of this investigation, it was learnt that the nucleic acid fraction possesses almost no capacity of toxin production, but that most part of the capacity is transferred to its protein fraction. However, since it was also suspected that nucleic acid might have lost its capacity owing to such drastic chemical procedures as Schneider's fractionation method, the authors treated nucleic acid before investigating its production capacity, and found that its capacity is reduced not remarkably. When Hammersten's casein, which is considered to be a relatively pure protein, was employed in place of blood serum, the hemotoxin was also obtainable. In this case again, it was found that most part of the production capacity is transferred to its protein fraction. In view of the above facts, it was elucidated that the production factors of the Weld's hemotoxin do not exist in the minute amount of nucleic acid contained in the blood serum, but exist inn the serum protein.
In an attempt to learn as to which fraction of the serum protein contains the factor, the serum protein was fractionated by Cohn's low temperature ethanol fractionation, and the hemotoxin production capacity of each fraction was investigated. This experiment revealed that, although the capacity is divided to each of the fractions to certain extent, the largest portion is transferred to globulin fraction, and only a small portion is transferred to the albumin fraction. Furthermore, it was made clear that the albumin fraction is not the production factors, but that the globulin fraction contains the principal portion, because, when the albumin fraction was further purified and isolated, it was found to be containing almost no hemotoxin production capacity.

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In the present paper, the authors observed the relations between mother and her new born baby from the view point of the isoagglutinins in the sera from both mother and the umbilical cord of her new born baby.
A total of 449 combinations of mother and new born baby were examined and the results were tabulated by the presence or absence of the isoagglutinins in the sera from the umbilical cord of the new born baby as follows.

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Following their recent report, the authors observed 449 combinations of the mother and her new born baby from the view point of the presence or absence of the isoaggiutinins in the sera of the mother and of the umbilical cord, and the results were compared with the blood groups of the mothers.
The blood groups of the mothers and the serum-types of the new born babies were as iollows:
A_β, A_o, B_α, B_o, O_α, O_β, O_αβ, O_o, AB_o
In view of the above findings, the authors daubted that the isoagglutinins contained in the serum of the mother is readily transferred to the foetus through the placenta.

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In the present work, the authors examined the sera from the normal humans, from the mothers and their new born babies for the anti-complementary actions and the antisheep hemolysin.
No difference was found among the above sera examined in respect to the anti-complementary actions, therefore, a reasonable amount of complement could always be used in the titration of the hemolysin.
The hemolysin titres of the sera from the mothers were almost equal to those of the normal human sera.
The hemolysin wes found to be absent in 14 out of 95 sera from the mothers, whereas it was found to be present only in 3 out of 98 sera fromm the umbilical cords.

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As to the measurement of blood pressure, various methods have been reported, either direct or indirect methods. However, the discovery of the fact by Korotkow that the minimum and the maximum pressures can be measured from the blood vassel tones originated at the pressure with manchette was a great achievement. Nevertheless, the method, which is most commonly in use even at the present time, contains various difficult points. By these reasons, long record the artery blood pressure wave indirectly from the radial artery by means of Piezo effect, while Roberts et al directly from the electromanometer.
The author recorded the blood pressure employing an electromanometer, which was recently devised by his Department and is possessing a superior frequency specificity. Comparing the result thus obtained with that obtained by Korotokow's stethoscopic method, the author found that the result obtained by the latter method is extremely inaccurate unless the pressure of manthette is lowered very slowly, and that the artery blood pressure wave accurately expresses the blood pressure even in the cases of thr stethoscopic gap or in the cases when the minimum blood pressure is measured as zero, which are often experienced in the stethoscopic method.

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The action current vas led from Cambarus heart, and recorded by Braun tube oscilloscope. The ECG recorded is consisted from slow and fast components. Both of them are superposed by spik like potentials. It seems that the pace maker exists at the middle part of the heart. Adrenalin causes to acceralate the heart beat, and evokes repetitive spike potentials.

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In the present paper, the authors attempted to investigate and discuss the actions of nicotine, which is an alkaloid possessing pharmacologically specific actions, employing developing hen's eggs according to the methods reported in the past. In the present work, experiments were conducted aiming at the elucidation, of the influence of nicotine on the general development of chick embryo and the disorders induced thereby.
The development of chick embryos in the developing hen's eggs injected with nicotine is hindered, and not infrequently pronounced edema covering the whole body is observed. The degree of the edema corresponds to the rise of the concentration of nicotine with which the eggs were treated. In these cases, the amount of allantoic fluid is found to be remarkably reduced, and a tendency of reduction in the amount of calcium, magnesium, sodium and potassium secreted in the urine is observed.

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As a part of the series of pharmacological studies on the embryonal stage, which are being carried on for many years in the author's Department, the author re-examined the adrenaline content of the adrenal glands of the normally developing chick embryo in the first place, and examined the influences of nicotine and pyridine derivatives on the general development and the adrenaline content of the adrenal glands of the chick embryo in the second place, attempting to study the actions of nicotine on the animals in the ernbryonal stage. On this occasion, pathological histological examinations were simultaneously conducted.
The presence of adrenaline in the adrenal glands of the chick embryo in the normal development is clearly proved since 12 days after the hatching, and the content is found further increased on the 15 th and 18 th days from the hatching. The addition of nicotine (or nicotine tartrate) to the developing egg even further increases the adrenaline content in the adrenal glands compared with that in the corresponding stage of the normal development. However, pyridine or pyridine derivatives (INAH, nicotinic acid, nicotinamide and coramine) do not possess as much action in the same line as nicotine possesses, or they exercise almost no influence on the adrenaline content in the adrenal gland.

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