A case of f ortyeight year old male who had abdominal tic cramp with brain syphilis was described. He had an irregularly repeated, purposeless stereotyped movement on his abdomen. This differs from tremor in the abscence of rhythm, and from chorea in its repeated pattern. It belongs to the group of compulsion neuroses, for the patient feels an urge to make, or allow the the occurrence of the movement. He was able to postpone the appearance of the movement by effort of will, but the urge increased, so that the movement would occur in spite of his efforts to prevent it.
Antisyphilitic therapy was effective to cure tic cramp in this case.

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An autopsy case of 60 year old male of Monckeberg's arteriosclerosis was described. Deposition of calcium was demonstrated in arterial walls. The blindness, chief complainment of this patient, was cuased by destruction of see centre of occipital lobe due to arteriosclerosis. The, pioture of Kimmelstiel-Wilson syndromes was found out in kidneys histopathologically.

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A 45-year-old female, who had suffered from hypertension and neuralgia in her right thigh, noticed a miliary painles subcutaneous nodule 3 years ago, which became gradually greater and caused pain on pressure and spontaneous neuralgic pain.
A hard spherical subcutaneous nodul about size of pea was situated on the extensor site of right thigh 6 cm above the patella. Merely touching the tumor caused severe pain, which irradiated in the inguinal region.
Microscopically, the tumor was situated in subcutis and was composed of bundles of smooth muscle cells and encapsulated. There were large number of blood vessels with irregularly shaped lumina scattered in the tumor. The wall of blood vessels were thickened and were sorrounded by muscular bundles connected with that of the tumor. The diagnosis was angioleiomyomra of the skin.

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There have been a good deal of studies published on human paranasal sinus, and its formation was discussed by Welcker, Zuckerkandl, Anton et al. But none of themm was of complete satisfaction. In the present study, canine frontal sinus was examined in the light of comparative anatomy and the results obtained were as follows :
1. On one side of the dog's frontal bone, generally, there are two cavities, A and B, but very rarely three cavities are formed by separation. The anterior cavity (A) of the two cavities is small and the posterior one (B) is large.
2. A-cavity, which is large, is irregular in shape, while B-cavity, which is small, is found very simple.
3. Both A- and B-cavities are larger in male than in female and larger on the right side than on the left side.
4. There grow many creeks in the frontal sinus, especially, in the posterior wall of Acavity.
5. Into the orifice of frontal sinus, ethmoidal concha intrudes showing turbinals, the most cases of which are seen in A-aperture sinus, where they show outside turbinals, but in the case of B-cavity, they show inside ones.
6. Both A- and B-cavities lead to the dorsal ethmoidal meatus.
7. The author is of the opinion that A-cavity is the original frontal sinus, while B-cavity is a kind of the growth from the frontal cellules.

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Following the previous study on the frontal sinus, studies were made on the maxillary, sphenoidal and ethmoidal sinus. Dog's maxillary sinus is not in existence, it is nothing but the cavity grown in inside of the maxillary corpse joining the lamina paphracea of ethmoid. The volume of this cavity is 11.10±1.903 cc in the right, 10.86±2.360 cc in the left. In the dog, the sinus sphenoidalis does not exist. There is seen a recessus and the sphenoidalis in front of the body has not yet taken the shape of cavity.
As for the spongy matter of the interior body, it is absorbed a little, looks rough, and is not open to the recessus sphenoidalis on both sides. The ethmoidal concha is divided into three parts ; frontal concha, original ethmoidal concha and sphenoidal concha. Two frontal concha in the center lead to both A-cavity and B-cavity.
As for the original ethmoidal concha, it is divided into four endoturbinates and six ectoturbinates some growing independently and others in combination. While, sphenoidal concha are two in number both intruding into the recessus sphenoidalis.

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1. One half of the monoamine oxidase (MAO) activity in the homogenate of hog kidney was found in the mitochondria fraction and 1/3 of it in the microsome and supernatant fractions (SM) . Diamine oxidase (DAO) is a soluble enzyme and 83% of its activity was found in SM fraction.
2. Enzyme materials mentioned above were relatively stable and can be kept for 2-3 months in -20°C without appreciable lose of their activities.
3. For the manometric assay of MAO, following procedure is recommended : In the main well, 0.3 ml of enzyme preparation, 1.0 ml of sodium phosphate buffer (pH 7.2), 0.3 ml of 0.1 M semicarbazide, 0.3 ml of 1 M sodium azide and 1.1 ml of dist, water; in the side arm, 0.2 ml of 0.1 M tyramine HCl; and in the center well, 0.3 ml of 3.0 M KOH with filter strip.
Under these conditions, 1 molecule of oxygen was absorbed for each molecule of substrate when it was oxidized by MAO.
4. Sodium azide and semicarbazide were proved by the kinetics to have no influence on the reaction system of MAO.

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The spasmolytic effects of OMP, INAH and B1 on the rabbit and mouse were studied.
Features of the spasms appeared were somewhat different depending on the drug administered.. Development of spasms was inhibited more or less by the simultaneous administration of a centrall depressant such as Dilantin, Sulfonal, or Bromural.
When TOED was administered into the cranial cisterna of the rabbit, there appeared the spasms resembling to those caused by B₁ administration.
Moreover, when a large dose of B₆ was administered on the mouse, spasms appeared, but in this case they were not inhibited by the simultaneous application of OMP. It was found, therefore, the antagonism between OMP and B₆ is only for one way.

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As the circulatory system shows a marked difference in its function during pregnancy, studies on the arterial blood pressure wave during pregnancy are considered to be of significant value.
In this connection, the author investigated the arterial blood pressure wave of normal pregnancy, pregnancy hypertension and pregnancy toxemia availing the new apparatus devised by Akita.
As the result of this investigation, most of the cases of normal pregnancy and pregnancy hypertension were found to show normal arterial blood pressure wave. While, there were a considerable number of pregnancy toxemia cases found with abnormal blood pressure curve.
Analyses by the difference of time and pressure were also applied on individual wave comparisons being made with the period of pregnancy, arterial pressure and the pulse rate.
In the early stage of pregnancy, cases with the wave type I were larger in number than those with the wave type II. Cases with the wave type II have a larger arterial blood receiving capacity, larger diameter of fine arteries and stronger elasticity of the arterial wall indicating the smaller amount of cardiac labour. Generally speaking, it was found that the amount of cardiac labour and peripheral resistance increase toward the end of pregnancy.
Analyses of the blood pressure wave of pregnancy hypertension revealed that it was the functional rather than organic disturbance of the cardiovascular system.
On analysing the pressure wave of pregnancy toxemia, it was found that the blunt peak of a-wave shows vascular spasms and sclerosis, enlargement of c-wave and the wave types IV and V signifies the prominent increase in the peripheral resistance and also the increase in the final periodic blood receiving pressure of the artery indicates an increase in the amount of blood sent out.
As for the relation between the arterial pressure wave and the electrocardiogram, the blood receiving period was found to be longer than the systolic period of the electrocardiogram in most cases of pregnancy and this tendency was especially remarkable in the case of pregnancy toxemia.

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1. In order to induce experimental naphthalene cataract, normal rabbits fed on vitamin C deficient diet were administered of 30% olive oil suspension of naphthalene per os in a daily dose of 1g/kg body weight. They were divided into two groups of one received naphthalene suspension only and the other the same in combination with 50 mg vitamin C, and subjected to the clinical observation and pathohistological examination of the liver as well.
2. On comparison of the appearance and the spread of lesions, slight inhibition and retardation of their occurrence were recognized on the rabbits of Group II.
3. Following the histological injury due to the degenerative changes, there appeared the production of reticulm fiber and connective tissue developing liver fibrosis or cirrhosis of the liver.
4. Spread of the fibrosis into hepatic lobule was first recognized in the periphery of the lobule.
5. Changes observed on the rabbits of Group II, on the other hand, were only the circulatory disturbance, degenerative changes and extremely slight histological injury.
6. Difference in the intensity and the time of the appearance of lesions between the eye bell and the liver is considered to due to the organic predisposition including the differnce of vascular distribution. Accordingly, the toxic reactions caused by naphthalene are considered to be the morphological expression of the metabolic disturbance of hepatic parenchymatous cells, namely, they are due to the hypoxia caused by the tissue intoxication.

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