Serum iron, copper, transf errin and ceruloplasmin level were measured in rabbits receiving repeated injection of reduced ceruloplasmin and urinary erythropoietin isolated from patients of hypoplastic anemia, checking the number of erythrocytes, reticulocytes, hemoglobin level and bone marrow picture. These were compared with the rabbits placed under low atmospheric pressure.
The results obtained were as follows.
1) The serum iron level was lowered within one week, in all experimental groups of rabbits administered ceruloplasmin, apoceruloplasmin and urinary erythropoietin and of rabbits in hypoxic hypoxia.
2) The serum copper and ceruloplasmin value decreased in rabbits administered urinary erythropoietin and placed under hypoxic hypoxia, while it increased in the groups administered urinary erythropoietin and placed under hypoxic hypoxia, while it ceruloplasmin and apoceruloplasmin.
3) Reticulocytosis in peripheral blood and marked hyperplasia of bone marrow were observed in all experimental groups.
4) Serum total and unsaturated iron binding capacity increased markelly in all groups.
5) Plasma of rabbits receiving repeated injection of ceruloplasmin accelerated Fe⁵⁹ incorporation into peripheral erythrocytes of rats.
It is assumed that reduced ceruloplasmin has an erythropoietic activity as urinary ethropoietin.

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Strong continuous impingement was given to young rabbits with or without cutting the blood vessels entering into the femoral head from the posterior part of the capsule, and its effect on the bone, especially on the growing zone, was studied.
The experimental animals used were of 2 weeks old, weighting 200-250g. A continuous impingement of 300 times in a minute was given for 10 minutes every day onto the femur along to the long axis at the knee joint. The following results were obtained.
1) On giving the continuous impingement, the ossification was disturbed and marked change was recognized especially at the epiphyseal cartilage of the neck. Histologically the zone of resting cartilage and the zone of young proliferating cartilage decreased in their width, while the zone of maturing cartilage and the zone of calcifiing cartilage increased in their width. Trabeculae of the metaphysis became atrophic with thinned cortex.
2) In the group with the cutting of the blood vessels, their changes were marked. Histologically, not only the zones of resting and young proliferating cartilages but also the zone of maturing cartilage decreased in their width.
3) The union at the transitional zone between the femoral head and the great trochanter was prolonged.
4) The articularcartilage also thickened more than that of the contorl group because of a disturbance in ossification.
5) Coxa vara increase during the continuous impingement. In the group with the cutting of the blood vessels, the ante-torsion of the femoral neck increased until the third week, but decrased thereafter. Thus, the increase in the ante torsion seemed to be related to the position of the Femur in the rabbits.
6) In this experimeht, no effect of the impingement was recognize the Length of the bone, but its slight increase was recognized in the group with the cutting of the blood vessels, the imp-ingement demonstrated no bone destruction, fibrosis nor cartilagenous callus in the femoral head.

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The sprain is one of the most popular traumatic lesions of the knee joint and the lesion easilly left many sequelae such as pain, swelling and stif ness of joint if some adequate treatment were not applied. However basic studies on the lesion have scarsely been reported
In this study, the experimental sprains were produced on the knee joint, especially, on its collateral ligament of rabbits. The clinical, pathological and histological changes were observed on 1, 3, 5 days and 1, 2, 3, 4, 6, 8 and 12 weeks after the procedure.
According to the treatment, those experimental sprains were separated into five groups :
I) without treatment,
II) fixed by plaster cast in forced varum position,
III) cooled for 30 minutes in the ice water and then fixed in cast,
IV) cooled for 30 minutes compressed with sponge rubber and then fixed by cast compressed with dry sponge rubber, and
V) injected intramuscularly with α-chymotrypsine 5 ch. U., after treatment as like as IV. The following results were observed:
1) The lateral laxity of the knee joint was physiologically 8°-13° in its extended position. However sprained knees without complete repture of the collateral ligamnet moved to further lateral 15°-22° and this over-laxity reduced to physiological range after six weeks when adequate treatment of applied. Sometimes abnormal movements appeared in untreated knee joints. They needed more times to recover than treated ones.
2) Both elongation in length and narrowing in width of collateral ligament were observed in measurement in almost all sprained knees. Although they showed no obvious rupture of collateral ligament, they had abnormal laxity to lateral.
Those changes of the ligament in treated knees disappeared earlier than those in untreated ones.
3) The subcutaneous bleeding was noticeable in the area of the attachment of collateral ligament to tibia. This bleeding disappeared within four to six weeks in treated knee, however this change still remained over eight weeks in untreated ones.
4) The histological changes in experimental sprains were following; the severance of ligament fibers, bleedings, loosing, dissociations, local edema and round cell infiltrations. The changes were not prominent in treated knees and the degree of these changes reduced gradually in II, III, IV, V groups respectively ; some of these changes, i, e., bleedings, loosings and degeneration of muscule fiber, still remained for over eight weeks in untreated ones, however, the changes even bleedings, local edema and round cell infiltrations, disappeared in treated ones, especially in III, IV and V groups.
5) Recovering from the macroscopical or histological changes caused by the sprains was distinctly delayed in untreated knees.
The most of ective treatments were cooling, compression and fixation. Knee treated withohymotrypsin recovered from sprain earlier than those applied other treatment, although α-chymotrypsin-treated knee seemed to get worse in the initial period of treatment.
6) It was concluded that an appropriate initial treatment for sprain determined the follwing process of recovery and that recovery time would be shorten and therefore sequelae could be prevented or diminished if the treatment was enough to prevent the secondary impediment.

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So many factors as for etiology of neonatal hyperbilirubinemia have been reported by many workers. However, only few regarding the role and significance of giant cephalohematoma in patients with neonatal hyperbilirubinemia were seen. It is the purpose of this paper to present the case of neonatal hyperbilirubinemia associated with giant cephalohematoma.
A three-day-old male was admitted to our hospital because of marked jaundice. At the time of admission, giant hematoma which was confirmed by X-ray and needle biopsy later was noticed on the left side of head. In spite of the through examination for jaundice including biochemical, serological and bacteriological study, no etiological factors were detected beside cephalohematoma.
Although there is a possibility for formation of bilirubin from the result of red cell destruction in the cavity of hematoma, no complete explanation for the cause of jaundice in this patient could be obtained. However, it might be suggested, at least in part, that the decrease of hemoglobin level in the hematoma corresponding the level of bilirubin concentration in the serum contribute to the cause of jaundice.

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