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Volume 62 (2002)
- Issue 6 Pages 357-
- Issue 5 Pages 287-
- Issue 4 Pages 205-
- Issue 3 Pages 137-
- Issue 2 Pages 73-
- Issue 1 Pages 1-
Volume 62, Issue 3
Displaying 1-8 of 8 articles from this issue
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[in Japanese]2002 Volume 62 Issue 3 Pages 137-148
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 3 Pages 149-168
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
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Genshu TATE2002 Volume 62 Issue 3 Pages 169-177
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA new clinicopathologic entity, “chronic idiopathic jaundice with unidentified pigment in liver cells, ”was proposed in 1954 by Dubin and Johnson and at present is called Dubin-Johnson syndrome (DJS) . Pathogenesis of DJS was thought to be an impairment of conjugated birilubin-secretion into the bile canaliculi. In 1997, mutations of the responsible gene for DJS were reported by Paulusuma et al. revealing that this gene, named multidrug resistance protein 2 (MRP2) and at present also called ATP-binding cassette, sub-family C, member 2 (ABCC2), encodes a transmembrane protein which belongs to a ABC transporter family. In comparison with the clinicopathologic analysis, the gene analysis of DJS is still not sufficient. Only ten kinds of mutations of the MRP2/ABCC2 gene in DJS have been reported.In this review, mutations of the MRP2 gene in DJS, as well as in vitro pathogenesis of abnormal MRP2 protein, will be described.View full abstractDownload PDF (4012K) -
Seiichiro INOKUCHI, Masakazu SHIBATA, Junji ITO, Masataka SUZUKI, Tets ...2002 Volume 62 Issue 3 Pages 178-187
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn CT images at the 4th lumbar vertebra level in 58 males and 59 females from young male students to elderly inpatients, body composition and muscle density were measured and age related changes were analyzed. The following results were obtained. 1) Body composition: In males, the bone and muscle layer was the largest followed by the abdominal cavity and subcutaneous fat layer in this order in students (20s) three layers were nearby equal in young adults (20s and 30s) and in middle age (40s and 50s) . In the elderly inpatients (80s and 90s), the subcutaneous fat layer was lowest. The changes according to age in females were similar to those in males. 2) Muscle cross-sectional area: In females, age changes were milder than those in males and slight decreases in the female elderly inpatients were similar to males. 3) Muscle density: In young adult males, low density changes increased slightly in students and were more pronounced in the middle age group. In the elderly inpatient group, marked low density changes were found in all muscles.View full abstractDownload PDF (2377K) -
—A Comparative Study of low and Medium Moleular Weight Hydroxyethyl Starch Substitutes—Kyoko MARUTA2002 Volume 62 Issue 3 Pages 188-193
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe studied the relative efficacy of two plasma substitute therapies in a canine model for hemorrhagic shock. Anesthetized dogs were bled to maintain a mean arterial pressure (mAP) at 50 mmHg and then administered a single bolus injection of 6 % hydroxyethyl starch (HES) with a molecular weight of 70 kDa (HES70 group) or 200 kDa (HES200 group) at a volume equivalent to the blood withdrawn. The efficacy of both therapies in maintaining the hemodynamic variables, the plasma colloidal and crystalloidal osmotic pressures (Pcop and Posm), and the circulating blood volume (CBV) were investigated. CBV was measured by the pulse-dye densitometry (PDD) method. After resuscitation, hemodynamic variables were better maintained in the HES200 group than in the HES70 group. Particularly, mAP, mean pulmonary arterial pressure, pulmonary arterial wedge pressure, cardiac index, left ventricular stroke work index, and maximum rate of left ventricular pressure change, were maintained at a satisfactorily stable level in the HES200 group as compared with the HES70 group. Moreover, Pcop and CBV in the HES200 group were significantly greater than those in the HES70 group. On the other hand, Posm did not differ between the two groups. HES200 may be a more effective volume replacement therapy than HES70 for induced hemorrhagic shock because of improvement and maintenance of hemodynamic variables, CBV and Pcop.View full abstractDownload PDF (639K) -
Masashi YATSUZUKA, Takao OKAMATSU, Akira GOMI, Jun-ichi SUZUKI, Komei ...2002 Volume 62 Issue 3 Pages 194-200
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSFrom January 1970 through December 1999, 682 neonates were treated at the Department of Pediatric Surgery, Showa University Hospital. Six hundred patients were operated on for congenital malformations mainly esophageal atresia (41 cases), hypertrophic pyloric stenosis (54), intestinal obstructions (117), midgut malrotation (41), aganglionosis (44), anorectal malformations (90), gastrointestinal perf orations (49), congenital diaphragmatic hernia (CDH, 40), abdominal wall defects (AWD, 40), solid and cystic tumors (35), and others (131) . The overall postoperative mortality rate was 11.7%. In the last decade, the mortality rate has dramatically decreased to 8.0%. However, there has been a higher incidence of mortality (20.4%) in the low birth weight infants. The survival rate was better significantly for infants with congenital abnormalities than those with acquired disorders such as necrotizing enterocolitis (NEC, 50.0%) . More aggressive and sophisticated surgery in NEC, antenatal diagnosed CDH and severe AWD would increase the survival rate under perinatal intensive care during the next decade.View full abstractDownload PDF (763K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 62 Issue 3 Pages 201-203
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (317K) -
2002 Volume 62 Issue 3 Pages vi
Published: June 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (172K)
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