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Volume 38 (1978)
- Issue 6 Pages 571-
- Issue 5 Pages 455-
- Issue 4 Pages 349-
- Issue 3 Pages 245-
- Issue 2 Pages 129-
- Issue 1 Pages 1-
Volume 38, Issue 3
Displaying 1-12 of 12 articles from this issue
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Kazuo Imamura, Hideki Yoshida, Takao Ikeuchi, Toyohiko Saito, Yoshio H ...1978 Volume 38 Issue 3 Pages 245-251
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe mentioned about the present ways of treatment of the bladder carcinoma ; surgical, physical, radio and chemical therapy.
(1) For the low stage (till B1 or T2) tumors, chemical, physical therapy and/or electroresection, -coagulation and partial cystectomy by way for surgical treatment are employed.
(2) For high stage, when the tumors are limited in the bladder, they are treated with total cystectomy. But when the tumors are localized in a small part of the bladder, partial cystectomy can be also employed.
(3) In case the tumors have already spread over the bladder, the bladder isolation or other treatments should be selected.
Further study of the chemical treatments should be encouraged hereafter.View full abstractDownload PDF (2614K) -
Masahiko Arita1978 Volume 38 Issue 3 Pages 253-262
Published: June 28, 1978
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSThe results of RAST to mite, silk, egg white, shrimp and buckwheat allergen were compared with those of clinical allergy diagnosis by scratch tests, case history and serum IgE levels. Seventy children were selected because of suffering from atopic allergy to more than one substance, resulting in bronchial asthma and other symptoms.
In this study, RAST was performed using batches of allergen perticle complex and 125I-labbeled anti-IgE as in the study reported by Wide et al. APC were prepared in the method described by Ceska et al.
An over-all correlation between scratch tests and RAST was established in 76.2 per cent. Result of RAST showed higher correlation with scratch tests to inheller antigens.
In any antigen, serum IgE levels were not correlated with RAST counts. Clinical history of food hypersensitivities was well correlated with positive RAST.
Finally, significantly positive correlation of result of carefully performed skin tests with RAST values suggests the possibility that the RAST can be employed as reliable diagnostic aid.View full abstractDownload PDF (1021K) -
IMMUNOGENIC POTENTIALITY OF BACTERIAL LIPID A COMPONENTS IN CARRIER-FREE FORMS TO MOUSE SPLEEN CELLSAkira Mita, Hidekazu Ohta1978 Volume 38 Issue 3 Pages 263-272
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSImmunogenic activities of an alkali-treated lipid A and a heptoseless glycolipid (KDO-lipid A) derived from a R595 rough mutant of Salmonella minnesota were investigated in male mice by the methods of Biozzi et al. and Cunningham.
Treatments with suitable forms of the materials led to occurrence of plaque- and rosette-forming cells with specific antibodies for alkali-treated lipid A coated to sheep erythrocytes. Following two subcutaneous treatments with Freund's adjuvants, intravenous injection of a complex of alkali-treated lipid A with acid-heated bacterial cells activated the mouse spleen cells to contain direct plaque-forming cells with anti-lipid A antibodies. Moreover, two intravenous sensitizations of the complex could induce syntheses of IgM and IgG antibodies with the specificity. Even when alkali-treated lipid A or glycolipid in a carrier-free form was intravenously introduced, mice were able to produce the anti-lipid A antibody. On intraperitoneal immunization with the lipid A alone, mice had no plaque-forming cells, but rosette-forming cells in the spleen. However, mice receiving the same treatment with the glycolipid alone had two types of the antibody-producing cells simultaneously.
The anti-lipid A antibody-producing cells were also observed in thymus cells obtained from glycolipid-treated group.View full abstractDownload PDF (3670K) -
—ESPECIALLY CORRELATION WITH DIFFERENTIATION AND DEVELOPMENT OF THE OTHER INTERNAL ORGANS—Mahito Katsumata1978 Volume 38 Issue 3 Pages 273-295
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSOf 279 cases, which have been autopsied at the 1st Department of pathology, Showa University School of Medicine during the past 6 years from 1971 to 1976, 161 still-born or neonatal infants who were born from mother who had a disease that could give rise to so called immature, postmatuated, and malformed infants were excluded from this research and the rest 118 infants classified into AFD, SFD, LFD according to gestational weeks and body weight. The differentiation and development of the thyroid during the late half fetal and neonatal perioid of each case was studied histopathologically. Moreover, the other internal organs were correlated with the thyroid gland during these periods. That is, the differentiation and development were compared histopathologically
The results obtained are as follows ;
1) On SFD, most cases reveal only the first development but some cases reveal the second development in early stage, and in each case differentiation and development between parenchyma and mesenchyma often shows lack of balance.
2) On LFD, the first and the second development were observed at a higher rate than on SFD. And in each case differentiation and development between parenchyma and mesenchyma were in parallel equally on AFD.
3) On neonatal stage, the differentiation and development of the thyroid gland were observed only on the thyroid before completion of the first development, but on the thyroid, either the first development is completed at birth or, the differentiation and development of thyroid gland shows a tendency not to progress.
4) On the late half fetal stage, the differentiation and development of the thyroid gland showed characteristic two phase pattern and differed from that of the other organs, lung, kidney and aderenal gland.
And abnormality and immaturity of the development and differentiation of the thyroid gland on SFD and LFD were extremely remarkable compared with that of the other organs. So the author infers that the fetal thyroid gland develops most variously histopathologically compared with the other organs.View full abstractDownload PDF (7411K) -
Masanao Shibuya1978 Volume 38 Issue 3 Pages 297-304
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSNeurosecretory neurons were identified in the rat supraoptic nucleus (SON) by the antidromic response to stimulation of the neurohypophysis. I investigated the effects of inhalation anesthetics (nitrous oxide, halothane, diethyl ether) on the unit activity of antidromically identified neurohypophysial neurosecretory neurons. As inhalation of anesthetic agents, 67% nitrous oxide-oxygen (GO), 0.3%-0.5% halothane-oxygen (OF), 0.3%-0.5% halothane-67% nitrous oxide-oxygen (GOF), 6%-12% diethyl ether-oxygen (OE), 6%-12% diethyl ether-67% nitrous oxide-oxygen (GOE) were studied in 5 identified units respectively.
Inhalation of GO showed no change in spontaneous firing rate of the units. OF and GOF showed variant changes of the unit activity.
As the case of OE and GOE, 4 out of 5 tested units exhibited inhibition of the unit firing after inhalation respectively.
From these results, it was concluded that the most of neurohypophysial neurosecretory neurons of the rat supraoptic area were inhibited by inhalation of diethyl ether.View full abstractDownload PDF (4467K) -
Yasuo Kamada, Chifuyu Takeshige1978 Volume 38 Issue 3 Pages 305-314
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSince acupuncture analgesia is abolished by lesion of periaqueduct central gray (PAG) or by treatment of naloxone and since the low frequency stimulation used for acupuncture analgesia is a kind of induction methods to induce animal hypnosis, the possibility of the involvement of PAG and of endogenous morphine like factor in acupuncture analgesia and a similarity of analgesia during animal hypnosis with the acupuncture anesthesia have been suggested. These proposed problems were investigated by recording single unit discharges of PAG and the center core of midbrain reticular formation (MRF) in unanesthetized and unrestricted 30 rabbits.
Spontaneous unit discharges of 89 PAG and MRF neurons which were selected not to responded to noxious stimuli were changed by induction methods to cause animal hypnosis such as inversion (INV.), pinching the base of the ear (P.E.) or acupuncture stimulation (A.S.) . Those changes were an increase or a decrease of firing rates of unit discharge which were observed in 28 and 63 neurons respectively in 126 such trials. 64% of these neurons were commonly responded in same direction by two or three procedures (INV., P.E. and A.S.) . In A.S., the changes of firing rates were induced after latent period and the induced changes lasted for long time after termination of stimulation (after-effect) . Unlike A.S., a latent period was lacking and after-effect was very slight in respondises to INV.. A majority of these neurons responding to INV., P.E. and A.S. were also responded in the same way to systemic application of morphine.
The data indicate that 1) the PAG is involved in the mechanism which causes acupuncture analgesia and analgesia during animal hypnosis ; 2) a morphine like substance is also involved in this mechanism and 3) the acupuncture stimulated state should be classified as animal hypnosis.View full abstractDownload PDF (4635K) -
GENERAL PHARMACOLOGICAL ACTIVITIESSadao Nakayama, Hiroyuki Matsuo, Minoru Nomi, Koji Sakamoto, Yoshie To ...1978 Volume 38 Issue 3 Pages 315-322
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe have investigated the general pharmacological activities of diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105), and obtained the following results.
1. NKK-105 has shown a transient inhibitory effect on respiration, and lowering of blood pressure in rabbits by intravenous injection by a dose of over 10 mg/kg.
2. It has shown an inhibitory effect on the isolated hearts of guinea pigs with a dose of over 1×10-5g/ml, and had no effects upon preatroinization.
3. It has also shown a same inhibitory effect on the isolated smooth muscles of guinea pig trachial muscle, rabbit ileum, guinea pig ileum, rat uterus and guinea pig vas def erens with a dose of over 1×10-6-1×10-5 g/ml. Muscle contraction induced by acetylcholine, nicotine, oxytocin, noradrenaline and barium chloride or electrical stimulation has been inhibited with pretreatment of NKK-105.
4. On the intestinal ability to transport charcoal meal in the intestine of mice, it has also shown an inhibitory effect with a dose of over 100 mg/kg.
5. NKK-105 has increased excretion of urine and electrolytes in mice and rats with a dose of 10, 50 mg/kg, p.o., however, it has shown an inhibitory tendency with a dose of over 250 mg/kg, p.o.. Additionally, NKK-105 has never had any effect on serum electrolytes with a dose 500 mg/kg, p.o..View full abstractDownload PDF (2885K) -
—ESPECIALLY THOSE ON EFFECTS OF TOTAL DOSAGE AND PATIENT'S AGE—Seishi Nagano1978 Volume 38 Issue 3 Pages 323-332
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSPituitary-adrenocortical functions were studied in those patients who had been treated with adrenocortical steroids by means of insulin stress test, rapid ACTH test and ACTH Z (depo-tetracosactide) intramuscular injection test. Particulary, it was investigated in connection with the effects of the total dosage of steroids administered and of patient's age.
In patients received 2000-5000 milligrams of steroids in predonisolone base, the blood cortisol response was subnormal in insulin stress test, and it was markedly decreased in patients receiving over 5000 milligrams, especially in aged patients scarcely any response could be found.
By rapid ACTH test, adrenocortical responsiveness reduced in the old ages already in patients receiving 2000 to 5000 milligrams steroid in predonisolone base. These findings suggested that by increasing the amount of steroids, pituitary-adrenocortical function of old men were apt to be supressed earlier than that of young men, and the patients treated with quantity of predonisolone from 2000-5000 milligrams were situated namely in “transitional stage” to marked pituitary-adrenocortical disfunction.
Urinary 17-OHCS response to first ACTH·Z injection in aged subjects were also lower than that in young men. When the patients had received continuous stimuli by ACTH·Z, most patients responded supernormal in urinary 17-OHCS levels. But the maximum urinary 17-OHCS levels following prolonged large quantity of corticosteroids administration were as half as that of small quantity administration of corticosteroids.
From the investigations in cases treated with both steroid and ACTH·Z, if we want to withdraw patients from steroid by ACTH·Z injection, especially in the patients with prolonged large quantity of steroids, we had better administer ACTH·Z to them about 3 times a week for several months after withdrawal from steroid.View full abstractDownload PDF (1133K) -
Katsuji Oguchi, Shinichi Kobayashi, Jun Fukata, Hironori Sato, Ryuichi ...1978 Volume 38 Issue 3 Pages 333-338
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEffects of various heavy metals such as HgCl2, K2Cr2O7, Na2Cr2O7, CdC12 and CrCl3 on monoamine oxidase (MAO) in dog serum and in mitochondria from dog liver and brain were studied using a modified method of McEwen and Cohen and a standard Warburg manometric method. On addition of various metals at a concentration of 10 mM, MAO activity in serum with benzylamine as substrate was completely inhibited by HgCl2, about 40% of the activity was inhibited by K2Cr2O7 and Na2Cr2O7 and about 20% of the activity was inhibited by CrCl3. Inhibitory effect on MAO in serum by HgCl2 and Na2Cr2O7 was found to be irreversible. On addition of 10 mM CdCl2, mitochondrial MAO activity in liver was inhibited by 20% and about 40% inhibition of the activity was also found in brain with tyramine as substrate. MAO activities with benzylamine as substrate in both organs were inhibited by 25% with the same concentration of CdCl2. On addition of HgCl2 at a concentration of 1 mM, complete inhibition of mitochondrial MAO activities in liver and brain was observed with tyramine as substrate. However, no inhibitory effect on MAO activities in liver and brain by addition of CrCl3 with these substrates was observed. With tyramine as substrate 30 mM Na2Cr2O7 showed about 55% increase in MAO activity of dog brain, while about 25% decrease in the activity of dog liver was observed. MAO activity in dog liver with benzylamine as substrate showed about 30% decrease but about 50% increase in the activity of dog brain. From these results, it was suggested that there were different functional forms of mitochondrial MAO in dog liver and brain.View full abstractDownload PDF (724K) -
Hiroyasu Baba, Hirotsugu Munechika, Yasushi Koga, Osamu Iwasaki, Hisao ...1978 Volume 38 Issue 3 Pages 339-340
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe typical radiological picture of ascariasis in the small intestine was demonstrated incidentally in a patient who came with abdominal tenderness.
The small bowel follow through study after upper GI series is emphasized to be worth while on occassion.View full abstractDownload PDF (1899K) -
Hirofumi Ohgiya, Toshihiko Uchida, Hiroaki Tsutsui, Takashi Atsumi, Ma ...1978 Volume 38 Issue 3 Pages 341-344
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is more than two years since our hospital was opened on July, 1975. At this time, we have made the statistical observations for the operated patients. Total number of the outpatients was 8128; 841 cases occupied about 10 % of them were the inpatients and 516 cases about 60 % of them were operated.
On the classification of the parts, the operation for the lower limbs was occupied about 60%, and on that of the disease, the deformation of the hip joint was done about 16%. Injury was within 30%, and very rare in our hospital which have no emergency system. Regarding the fracture of bone, almost all cases were the precedent introduced by other hospital by which our hospital has been characterized.View full abstractDownload PDF (284K) -
Yoshiko Fukushima, Seiko Sanada, Hiroyuki Zusho1978 Volume 38 Issue 3 Pages 345-348
Published: June 28, 1978
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe authous report the removal of epiglottic cyst of man, aged 46 and woman, aged 58 by oral aproach.View full abstractDownload PDF (3399K)
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