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Volume 42 (1982)
- Issue 6 Pages 701-
- Issue 5 Pages 539-
- Issue 4 Pages 409-
- Issue 3 Pages 281-
- Issue 2 Pages 149-
- Issue 1 Pages 5-
Volume 42, Issue 6
Displaying 1-15 of 15 articles from this issue
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[in Japanese], [in Japanese]1982 Volume 42 Issue 6 Pages 701-708
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (15298K) -
Chung-Jen LEE1982 Volume 42 Issue 6 Pages 709-724
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe periodic acid-chromic acid-silver methenamine (PA-CrA-silver) method and the chromic acid-phosphotungstic acid (Chromic acid-PTA) method were applied to the mouse mammary gland cells for the ultrastructural observations of the synthetic process of the secretory substances and the secretory mechanism of secretory granules in the late stage of pregnancy, lactating and postlactating periods, and the relationship between lysosomes and secretory granules during postlactating periods. Golgi apparatus in the mammary gland cells of pregnant and lactating mice with active secretion showed the gradient staining from cis side to trans side in both the PA-CrA-silver method and the Chromic acid-PTA method. The positive reaction products of the complex carbohydrates were recognized in the clear spaces of casein granules and multicasein bodies, but the cores showed negative reaction. The surfaces of microvilli and the lysosome showed positive reaction while fat droplets showed negative reaction. The cisternae of rough endoplasmic reticulum were weakly stained in PA-CrA-silver methenamine, but not stained in Chromic acid-PTA. The positive reaction of rough endoplasmic reticulum (RER) in the PA-CrA-silver reaction was easily observed in the pregnant and lactating periods, when the secretory mechanism became active. These findings suggest that some glycosylation occurs in RER in the mammary gland cells.
On the 4th day of the postlactating period, the innermost element of Golgi cisternae as well as Golgi associated endoplasmic reticulum lysosome system (GERL) showed intense acid phosphatase activities, whereas the staining of PA-CrA-silver as well as Chromic acid-PTA was greatly reduced in the Golgi cisternae. On the 8th day of the postlactating period, the primary lysosome was decreased but the secondary lysosome and autophagic vacuole were increased in the cytoplasm of mammary gland cells. This phenomenon indicates that the excessive casein granules are digested by primary lysosomes during postlactating periods.View full abstractDownload PDF (19174K) -
Rie MASUMI, Susumu SUNAGA1982 Volume 42 Issue 6 Pages 725-735
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn order to find out Mg metabolism for the perinatal period, Mg and its hormonal control factor (aldosterone, iPTH etc.) and Ca, P was measured in samples of plasma for 77 normal mature neonates and 84 immature neonates without sickness and 17 maternal, 26 umbilical venous blood, 21 umbilical arterial blood and 105 sick neonates (RDS, hypocalcemia, hypomagnesemia etc.) and 94 normal children. The following results were obtained. 1. It was found that both Mg and aldosterone crossed the placenta. 2. These data suggest that in both the fetus and the neonates after the age of 48 hrs, aldosterone may partly influence the Mg levels. 3. There was lower the mean plasma Mg levels and higher the mean plasma aldosterone levels in sickneonates (particulary in RDS) than normal neonates. These data indicated that we should take a count of hyperaldosteronism was a cause of hypomagnesemia in sick neonates.View full abstractDownload PDF (1215K) -
—ESPECIALLY MONKEY FOOT MUSCLES—Masataka SUZUKI, Seiichiro INOKUCHI, Hiroshi NAKANISHI, Teizo AJIRI, T ...1982 Volume 42 Issue 6 Pages 737-746
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSMuscle weight, number of muscle fibers and size of the muscle fibers were measured in foot muscles of adult crab-eating monkey (7.2 kg, male) and the results were compared with those obtained in human hand and foot muscles and monkey hand muscles previously by the same method. Histological specimens were embedded in celloidin and stained by H. E. The following results were obtained. 1) Total muscle weight and total number of muscle fibers in hand and foot of monkey and man followed an ascending order of monkey hand<monkey foot<human hand<human foot. No larger values than those of M. tibialis anterior were obtained in monkeys. On comparison with proper foot muscles after eliminating flexors and extensors of the foot, however, muscle weight was heavier in foot than in hand in monkey, but equal between hand and foot in man. Number of muscle fibers was equal between hand and foot in monkey, but smaller in foot than in hand in man. 2) In monkey foot, M, adductor hallucis and corresponding muscles were developed, with large diameter of muscle fibers. The opponent movement between the thumb and other fingers is probably active. 3) In monkey hand, muscles acting on concentration of fingers are developed, with muscle fibers of large diameter. 4) In human foot, muscles participating in arch formation in the longitudinal and transverse direction are well developed. In muscles participating longitudinal arch formation, the diameter of the fibers showed remarkable development. This probably represents development of muscles related to upright standing and walking. 5) In human hand, M. adductor pollicis and corresponding muscles showed development, with large number of muscle fibers. The diameter of the muscle fibers, however, are generally middle-sized or small, probably as the result of adaptation to fine movement.View full abstractDownload PDF (886K) -
FIRST REPORT : EFFECTIVE DOSAGE OF INTRVENOUS AMINOPHYLLINE THERAPYKimiko MATSUMOTO, Keisuke FUKUOKA, Hitoshi NIIYA, Hiromitsu SHU, Hidea ...1982 Volume 42 Issue 6 Pages 747-754
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIntravenous administration of aminophylline was studied in 20 asthmatic children. The serum concentration of theophylline in oneday was measured in the definite time intervals. A safe and effective dosage regimen for intravenous aminophylline administration can be based on these clinical observations. The serum concentrations of theophylline were measured by homogeneous enzyme multiplied technique (EMIT) . At the same time, EMIT was correlated with High-Pressure Liquid Chromatography (HPLC) in 39 patients' samples (r=0.980) and Gas Chromatography (GC) in 18 patients' samples (r=0.961) . In the group receiving a constant infusion of aminophylline (21 mg/kg/day), the serum theophylline level rose very slowly and was markedly low in the first stage of infusion. The initial infusion of 6 mg/kg, as a loading dose, was followed by the maintenance dose of 18 mg/kg/day. In this group, serum theophylline concentration was constantly maintained at the higher level of 10 to 14μg/ml by this method, and an immediate clinical improvement with increase in the PFR was observed. In conclusion, to obtain the ideal therapeutic range of theophylline level, we suggest that the initial infusion of 5 or 6 mg/kg over 5 min should be followed by 18 mg/kg/day, as a maintenance dose.View full abstractDownload PDF (864K) -
Kimiko MATSUMOTO, Keisuke FUKUOKA, Hitoshi NIIYA, Hiromitsu SHU, Hidea ...1982 Volume 42 Issue 6 Pages 755-762
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe clinical effects of sustained-release theophylline (Theona or Theona-P) and its serum theophylline level were studied in 21 asthmatic children. In the first group consisting of 11 cases receiving a single dose of Theona or Theona-P, 8.6±1.4mg/kg, the average serum theophylline level was measured across several time intervals ; 2.1±1.9μg/ml after 1 hr, 4.0±2.3μg/ml after 2 hrs, 5.5±1.9 μg/ml after 4 hrs, 7.5±2.5μg/ml after 8 hrs, 6.3±1.3μg/ml after 12 hrs, 3.0±2.5μg/ml after 12 hrs. The mean value of the maximal serum theophylline level was 8.0±2.4μg/ml 8 hrs following administration in 72% of the cases and 12 hrs after administration in 28% of the cases. In the second group consisting of 10 asthmatic children receiving average doses of 8.7±2.1 mg/kg/dose every 12 hrs, clinical efficacy and serum theophylline levels were measured. In our study, the average serum theophylline level was maintained with a slight variance of below or above 10μg/ml throughout the day. The mean difference between maximum and minimum serum theophylline levels was 4.3±2.3μg/ml with a 12-hr dosage regimen. In the second group, the frequency of asthmatic attack was significantly decreased and, also, pulmonary function test (PFR) showed remarkable improvement. Eighty percent of the clinically moderate and severe cases experienced therapeutic benefit after a 12-hr administration of sustained-released theophylline preparation.View full abstractDownload PDF (973K) -
Teruo NISHIYAMA1982 Volume 42 Issue 6 Pages 763-771
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSeventeen shigella strains of four subgroups: Sh. dysenteriae types-4, 6 and 7, Sh. flexneri types 1a, 2a, 2b, 3, 4a, 5, 6, variants X and Y, Sh. boydii types-1, 2, 5 and 6, and Sh. sonnei type-2 were grown on Medium D, described by Schlecht, S. & Westphal, O., and specific polysaccharide antigens were prepared from dried bacterial cells by the procedures I & II of Westphal, O. & Jann, K., and these were partly by Boivins' trichloroacetic acid extraction method. These were subsequently examined by immunoelectrophoresis. The antigens of all Shigella strains gave precipitin arcs, and immunoelectrophoretograms could be divided into two well-defined groups : IE groups I and II, according to the position of their precipitins formed on the arcs. The antigens of Sh. dysenteriae, Sh. boydii, Sh. sonnei and a few Sh. flexneri fell into the IE group I, which showed precipitin arcs both on the anodic side of the application basin and close to this. IE group II gave precipitin lines which were practically always located close to the application basin and included another Sh. flexneri which, however, belonged to IE group I. Extracts of Sh. sonnei and Sh, flexneri placed into IE group I contained a heat labile antigenic component which was destroyed or changed by heating at 100°C for 1 hour, although the entity was undetermined. It was difficult to separate the precipitin line of the group-specific antigen from the type-specific antigen by immunoelec-trophresis of the extracts examined. Cross reacting-antigens were observed between Sh. dysenteriae type-6, Sh. boydii type-6 and Sh. sonnei type-2, and one of these antigens was identified as an enterobacterial, common antigen of Kunin.View full abstractDownload PDF (5621K) -
STUDIES OF THE SMELL AND TRANSFER INTO FOODS OF STYRENE FROM POLYSTYRENE CONTAINERS AND WRAPPINGS USED IN FOOD PACKAGINGTakashi TATSUNO1982 Volume 42 Issue 6 Pages 773-782
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA study was conducted on the impact-resistance or foamed of polystyrene food packaging and its transfer into food substitutes (distilled water, 4% acetic acid, 20% ethyl alcohol and olive oil) such as fried noodles packed in polystyrene containers. The Methods followed in this study were maintained as close as possible to actual conditions of consumption ; the food materials were stored in polystyrene containers at room temperature and 40°C. Migrated and absorbed styrene in food was measured using gaschromatography: FID detector, 25 % polyethyleneglycol 20 M on chromosorb W/AW (60-80 meth) . After extraction with n-pentane and dimethylformamide. The detection limit was 0.1 ppm in various liquids or fried noodles. When polystyrene containers were contacted with water, an odor was given off; this was judged by five panellers. The methods and results of these studies are show in Tables 3-5, Figs. 1-9 and schemata 1-2.View full abstractDownload PDF (875K) -
Kenji TANAKA1982 Volume 42 Issue 6 Pages 783-796
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn the present study, 105 healthy female albino rabbits weighing 1070 g to 3500g were used. They were divided into two groups; one with sectioned sciatic nerve and one immobilized by a plaster cast (which consisted of 3 groups-plantar flexion position, 90°C, flexion and dorsal positions at ankle joint) . Manifestation modality of muscular atrophy on tibialis anterior was tested histologically and observed under a scanning electron microscopy (SEM) at regular intervals for five weeks. The following results were obtained: 1) The tibialis anterior of rabbits was divisible into three different color groups by Sudan Black B staining; white muscle fiber, red muscle fiber and an intermediate muscle fiber. Distribution in each muscle fiber was 46.5 % white, 28.4 % red and 25.1 % intermediate. Large amounts of white muscle fiber were found in the outermost muscle layer, while red was found in the deeper layer. Under scanning electron microscopic observation, the number of muscle fibers in each intraperimysium was 12 to 43. The diameter of muscle fibers was 8 to 70 dim, and the cross-section was polygonal (quadranqular, pentagonal and hexagonal) . 2) From the beginning, muscle weight decreased in the sectioned nerve group. Muscle weight initially increased and then decreased in the plaster cast immobilized group. 3) Great muscle fiber change was noted in the outermost layers of both groups. Changes such as atrophy developed earlier and to a greater extent in the sectioned nerve group than in the cast immobilized group. 4) In the cast immobilized group, muscle fiber of tibilias anterior developed a tendency to become round and expand earlier in the extension and intermediate positions than in the flexion position. 5) The above phenomena were remarkably revealed in white muscle fiber. Accordingly, atrophy often appeared in the outermost muscle layer, which include great amounts of white muscle fiber. 6) As for SEM, the sectioned group more cleared showed muscle fiber coarseness, connective tissue growth in intermuscle bundles and vascuolar degeneration than did the group immobilized by plaster casts. Those changes were more marked in the extension and intermediate positions than in the flexion. It was remarkable that such a large diameter of muscle should be of the white kind. 7) Prophylactic measures against muscle atrophy were considered on the basis of these results.View full abstractDownload PDF (14356K) -
Yoshimi OSAKABE, Hajime SUZUKI, Eisei NOGUCHI1982 Volume 42 Issue 6 Pages 797-803
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe role played by immune activity in survival was mainly investigated in 34 patients with stage IV primary lung cancer, and the following results were obtained respectively: 1. Survival suration was dignificantly longer in the patients with positive skin reaction than in those with negative. Peripheral lymphocyte counts and the duration of survival were significantly correlated in P. P. D positive patients, but not in P. P. D negative patients. 2. The CH50 titer was significantly higher in P. P. D positive patients. The CH50 titer and the duration of survival were significantly correlated in all the patients, especially in P. P. D negative patients. A significant correlation in P. P. D positive patients was not apparent. 3. IgG and IgA levels were significantly higher in all the patients as compared to controls, but no significance was seen in the level of IgM. No correlation was observed between the immuno globulin levels and the duration of survival in any of the patients. These results suggest that the complementary system may be activated from the time of decrease in cell mediated immunity and that the complementary system may play the most important role in patients with stage IV primary lung cancer when cell mediated immunity has almost vanished.View full abstractDownload PDF (646K) -
Akira HASHIMOTO1982 Volume 42 Issue 6 Pages 805-818
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe ultrastructural relationships between oxytocin (OT) -like immunoreactive neurons and other neurons in the rat paraventricular nucleus (PVN) and supraoptic nucleus (SON) were observed by means of immunocytochemistry using anti-OT serum. Axo-somatic, axo-dendritic or axo-axonic synapses between the same OT-like immunoreactive neurons were often observed. OT-like immunoreactive axon terminals containing both OT-like immunoreactive granules and immunonegative small vesicles were also observed to make synaptic contacts with immunonegative neurons in the PVN and SON. These OT-like immunoreactive granules were smaller than elementary granules in the neurosecretory nerve fibers of the neurohypophysis, but they were similar in size to those in OT neurons projecting to the extrahypothalamic regions. Additionally, applying the autoradiographic technique using 3H-noradrenaline (NA) or 3H-dopamine (DA) to the immunocytochemical sections, axon terminals labeled with silver grains after 3H-NA or 3H-DA injection were often observed near the OT-like immunoreactive neurons in both PVN and SON. In a limited number of cases, axon terminals labeled with 3H-DA were observed to make synaptic contacts with OT-like immunreactive nerve fibers. These findings suggest that catecholamine-containing neurons play important roles in the control of OT secretion in the OT-oroducing neurons.View full abstractDownload PDF (18709K) -
Akihiro KAWAUCHI, Wataru MATSUI, Seiji NAITO, Shinya OKAMOTO, Toshiyuk ...1982 Volume 42 Issue 6 Pages 819-824
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSRecently, ultrasonic diagnostic equipment has been so widely used that early diagnosis is much more frequent, especially in cases of digestive disorders. However, it is still difficult to diagnose pancreatic lesions or submucosal lesions of the upper digestive tract by scanning from the abdominal wall with electric linear scanners, because their potential for tissue characterization is still insufficient. Thus, ultrasonic endoscopy for direct scanning from the inside of the upper digestive tract has been recently developed (Olympus Co. and, Aloka Co.) . The authors had the opportunity of using this new equipment and to evaluate its efficiency in the diagnosis of three clinical conditions ; pancreas cancer, pancreas cyst and duodenal leiomyoma. Some difficulties arose in obtaining clear pictures, because the tip of the gastroscope, where the 5.0 MHz ultrasonic probe was fixed, was too long to be adequately controlled. If this device is improved from this standpoint, the scanning method would be useful in the diagnosis of epigastric diseases.View full abstractDownload PDF (6916K) -
Hiroyuki WATANABE, Umeki INOUE, Naokazu NUNOUE, Susumu TAGUCHI, Hirobu ...1982 Volume 42 Issue 6 Pages 825-830
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSMost cases of acute suppurative obstructive cholangitis are caused by stones, benign strictures or malignant tumors of the common bile duct. Here, we report, along with pertainent literature, an autopsy case of acute suppurattive obstructive cholangitis which occurred in the convalescent stage of acute viral hepatitis, with no definite obstructive lesions.View full abstractDownload PDF (2459K) -
Hitoshi FUNATOMI, Takehiro TAKENAKA, Umeki INOUE, Yoshio HATTA, Kazuhi ...1982 Volume 42 Issue 6 Pages 831-835
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case of bronchiolo-alveolar cell carcinoma in a 71-year-old woman is reported. The carcinoma cells had spread widely throughout the lung, except in the bilateral apical regions, but no invasions or metastases were found at autopsy. According to the Annals of Pathological Autopsy Cases in Japan (1977), there were 71 cases of bronchiolo-alveolar cell carcinoma and 3.6% against primary lung cancers. Only 16 of these had carcinoma limited to the lung and moreover, there were S cases of the diffuse infiltrating type. Finally, recent reviews on bronchiolo-alveolar cell carcinoma are summarized.View full abstractDownload PDF (4111K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1982 Volume 42 Issue 6 Pages 837-843
Published: December 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (885K)
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