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Volume 40 (1980)
- Issue 6 Pages 647-
- Issue 5 Pages 525-
- Issue 4 Pages 401-
- Issue 3 Pages 277-
- Issue 2 Pages 149-
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Volume 40, Issue 6
Displaying 1-11 of 11 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1980 Volume 40 Issue 6 Pages 647-651
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (689K) -
Hirotake MASUDA, Husaji KUMURA, Ken SHIOKAWA1980 Volume 40 Issue 6 Pages 653-667
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSRecently, many diseases producting vasculitis such as Periarteritis nodosa etc, have been noticed. However, even now, the study on the vascular changes involved in the nonspecific inflammation is insufficient. A study on the vascular changes was undertaken by using acute appendicitis as a non-specific inflammation.
Material and method: One hundred and seventy eight appendix vermiformises were sellected as “Acute appendicitis (Aschoff) ” out of 431 cases resected under “Acute appendicitis clinically”. The “Acute appendicitis (Aschoff) ” should represent a “Field” of a typical non-specific inflammation, followed by Aschoff's Staging, namely Stage-I: Small phlegmonous foci in crypts, II: Appendicitis phlegmonosa ulcerosa (within the 1st clinical day), III: Appendicitis ulcerosa gravis et phlegmonosa gravis (2nd day), IV: Appendicitis gangrenosa et perforativa ( 3rd day) and V: Appendicitis cicatricans (after 4th day) . Arteries involved in the “Acute appendicitis (Aschoff) ” were studied histopathologically.
Result: Arteries first show peri- and endoarteritis, then the inflammation extends in media from adventitia mainly, inducing hydropic and dissociating change. Neutrophilic granulocytes migrate into media showing panarterial inflammation at Stage-III on the 1st to 2nd clinical day. Then, if the inflammation would continued marked for a certain duration, a strain will occur in the arterial wall and some of arteries become expand. In some cases, if the expansion would continue, the structure of arterial wall will be destructed and aneurysm occurs on the 3rd clinical day. The aneurysmal arteries show soon intimal thickening or thrombosis to keep the luminal size in normal within a week.
Conclusion: Those changes of arteries observed in the “Acute appendicitis (Aschoff ), ” a kind of arteritis based upon the non-specific inflammation, should be concluded as a non-specific arteritis, considered reasonably applied in general.View full abstractDownload PDF (8452K) -
—AN AUTOPSY CASE CONSIDERED TO BE INFESTED MORE THAN 30 YEARS AGO AND A STUDY OF LITERATURES (COLLECTING 354 CASES) —Hirotake MASUDA, Masuo NITTA, Naofumi NAKAMURA, Ken SHIOKAWA, Hiroko K ...1980 Volume 40 Issue 6 Pages 669-688
Published: December 28, 1980
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSOn June 7, 1978, a 66-year-old unmarried Japanese woman suffering from liver fibrosis and SLE died of hepatic coma. Autopsy revealed cysticercus cellulosae in brain, heart, lung and subcutaneum, which was calcified and old. She had a past history of once living in Manchuria and repatriating in 1946.
Study of literature: 1. 354 cases of cysticercosis, including 302 Japanese, 19 Chinese, 12 Korean, and 18 unknown cases, were reviewed out of 219 literatures. 2. In “Annual of the Pathological Autopsy Cases in Japan, 1958-1975”, 6 cases were observed out of about 330, 000 cases (0.002 %) . 3. In Japanese cases, three groups could be classified, namely group-I (53%) —cases in Okinawa, group-II (41%) —cases once in abroad (Manchuria, China & Siberia 94%) and group-III (4.6%) —cases infected in Japan. 4. Historically, the Japanese cases have been observed since the first report in 1908, 3 cases (1908-1915, I-0, II-100, 111-0%), 2 cases (1916-1925, 0, 100, 0%), 12 cases (1926-1935, 25, 58, 17%), 203 cases (1936-1945, 76, 23, 0%), 53 cases (1946-1955, 2, 83, 13%), 17 cases (1956-1965, 6, 76, 18%), 9 cases (1966-1975, 13, 67, 22%) and 3 cases (1975-, 0, 100, 0%) .
Conclusion: Japan had probably no expierince of the contamination of cysticercosis until the Manchurian expedition in the Japanese-Russan War (1904-5) . The expedition and the migration became increased and the contamination of cysticercosis became simultaneously increased like oversea wave from Manchuria. Those phenomena had been continuing untill the end of the World War II (1945) and the final repatriation from Manchuria. In Okinawa, where the habit of pig breeding is common, cysticercosis became endemic. In Japan excluding Okinawa, soon after the disappearance of the contamination, cysticercosis became repidly dissapeared. Recently, the cases of cysticercosis including ours were only accidentally found by X ray films or autopsy, the most of which were supposed to be infested in Manchuria more than 30 years ago.View full abstractDownload PDF (9151K) -
Yoshifumi NAITOH, Kunio MARUYAMA, Yoshio KAI, Makoto SUZUKI1980 Volume 40 Issue 6 Pages 689-694
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSFour patients with renal carcinoma were performed renal arterial embolization using shredded Gelfoam and metalic coil with silk. Clinical symptoms, hematuria or flank pain, were improved. A large mass of tumor were gradually regressed. No severe complications ware nhserved except for mild febrile and flank pain of adverse reaction.
Two of these patients also underwent nephrectomy two weeks alter emaoilzaiion, which was less bleeding to a bare minimum, easy to carry out, and shortened the time of operation.
Embolization will be performed for adjuvant therapy to advanced renal carcinoma or prior to operation.View full abstractDownload PDF (2504K) -
Shinsuke SHIMIZU, Hiroko KOMUGI, Makoto MURAI, Chifuyu TAKESHIGE1980 Volume 40 Issue 6 Pages 695-700
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAnalgesia induced by acupuncture stimulation applied on around tsu-sanri point was measured by tail-flick latency of rats.
In acupuncture effective animals which showed a significant (p<0.05) increase of tailflick latency by acupuncture stimulation, intraperitoneally applied 1 mg/kg naloxone completely abolished acupuncture analgesia when it was applied on the well developed analgesia 30 minutes after on set of acupuncture stimulation. Such an antagonistic action of naloxone on acupuncture analgesia was dose-dependent. Tetrabenazine (25 mg/kg), a depletor of 5-hydroxytryptamine and catecholamines, also completely abolished acupuncture analgesia when it was applied on the well developed acupunctre analgesia, however its antagonistic action on acupuncture analgesia is more transient than that of naloxone, and last for 75minutes. This antagonistic action of tetrabenazine was also dose-dependent. Methysergide, an antagonist of 5-hydroxytryptamine, antagonized about 80% of acupuncture analgesia. This antagonistic action of methysergide was also dose-dependent.
These data indicate that acupuncture analgesia is induced by endogenous morphine like factors (MLF) which reveals its analgesic action by serotonergic and catecholaminergic systems.View full abstractDownload PDF (637K) -
Mitsugu HACHISU, Chifuyu TAKESHIGE1980 Volume 40 Issue 6 Pages 701-706
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn order to confirm the hypothesis that morphine analgesia is revealed by endogenous morphine-like factor which was released by morphine, the effect of morphine on the amount of met-enkephalin and tyr-gly-gly (TGG), one of the fragments of met-enkephalin, in the corpus striatum of rat was investigated using a high pressure liquid chromatography. Met5-enkephalin content was not changed by intraperitoneally injected 0.5 mg/kg morphine. However, TGG was significantly increased approximately 3 times by 0.5 mg./kg morphine and 1.8 times by 20 mg/kg morphine. The increase of TGG content by 0.5 mg/kg morphine was abolished by lesion of the dorsal periaqueductal central gray (PAG) in rats. A dose of 250 mg/kg D-phenylalanine, carboxypeptidase inhibitor, abolished the increase of TGG due to 20 mg/kg morphine administration.
These results indicate the possibilities that TGG in striatum was increased by activation of the pathway from the dorsal PAG to the striatum due to morphine. TGG was increased as a metabolite of met-enkephalin liberated by morphine and D-phenylalanine inhibit the metabolism of met-enkephalin.View full abstractDownload PDF (768K) -
Koji SAKAMOTO, Takako KASAHARA, Teruhiko MATSUMIYA1980 Volume 40 Issue 6 Pages 707-714
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe effect of L-5Hydroxytryptophan (L-5HTP), DL-5Hydroxytryptophan (DL-5HTP) and Benserazide-HCl (Ro4-4602) were investigated on the spinal ventral root reflexes by the intact and spinal cat preparations. These observation indicate that: 1) L and DL-5HTP were increased MSR but were decreased PSR. The effect of L-5HTP was faster than DL-5HTP on the spinal cord facilitation. 2) L-5HTP 75 mg/kg i, v. was not change at the case of the intact cat on neuronal activity. 3) L-5HTP 75 mg/kg by arteria carotis externa injection facilitated a shorter latency and the continuance prolonged. 4) Benserazide-HCl (Ro4-4602) 50 mg/kg i. v. inhibited MSR and PSR but 25 mg/kg i. v, not inhibited MSR and PSR. 5) Benserazide-HCl 25 mg/kg i. v. followed by L-5HTP 75 mg/kg i. v. was not change on the spinal neuronal activity. 6) L-5HTP 75 mg/kg i. v. at the same time Benserazide 25 mg/kg i. v, inhibited MSR but not inhibited PSR. 7) L-5HTP 75 mg/kg i. v, followed by Benserazide-HCl 25 mg/kg i, v. stopped the rising of MSR but not changed PSR. (3) -7) C1-C2 cut, not used dTc) .View full abstractDownload PDF (5980K) -
Tadashi KURIMOTO, Masako OKAZAKI, Keiko OZAWA, Koji SAKAMOTO, Teruhiko ...1980 Volume 40 Issue 6 Pages 715-724
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEffects of soedomycin, an anticancer agent, and Na2HPO4, its substrate, on general pharmacological and antigenic studies were investigated.
1) Soedomycin and Na2HPO4 showed no effects on mono- and polysynaptic reflex in acute spinal cats, and on blood sugar and serum cholesterol levels in rabbits.
2) Soedomycin and Na2HPO4 showed slight sleeping pattern on EEG and inhibition of spontaneous respiration, while they had tendency to increase on heart rate in chronic rabbits.
3) Soedomycin and Na2HPO4 showed slight contraction on smooth muscles (ileum of rabbits and peripherial blood vessel) .
It seemed that the contraction by soedomycin and Na2HPO4 acted on smooth muscles directly.
4) On capillary permeability in mice, Na2HPO4 showed no effects, but soedomycin had a slight inhibitory tendency.
5) Antigenicity test in guinea-pig included active and passive systemic anaphylaxis, passive cutaneous anaphylaxis, reversed passive Arthus reaction and Schultz-Dale reaction.
Soedomycin and Na2HPO4 showed negative results on their antigenicity compared with positive ones of horse serum.
From these result, it was suggested that soedomycin was the drug without side effects.View full abstractDownload PDF (6622K) -
Report 7: The effect of anti-alcohol action on EEG and spinal reflex in human and catTakemasa SHIRAISHI, Teruhiko MATSUMIYA, Yasuo WATANABE, Koji SAKAMOTO, ...1980 Volume 40 Issue 6 Pages 725-732
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe observed the effects of Diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105) on EEG when used to inhibit the effect of alcohol in acute and chronic cats, and humans; and investigated the effects of NKK-105 on spinal reflex in cats. A summary of results was as follows: (1) NKK-105: 500 mg/kg (p. o.), which was physically maximal dose, alone had no influence on EEG's. (2) NKK-105 100 mg/kg (p. o.) or 5-10 mg/kg (i. v.) clearly suppressed effects of 1000-3000 mg/kg (p. o.) . (3) NKK-105: 100 or 300 mg/kg (p. o.) inhibited about 80% of the effects of 1000-1500 mg/kg (p. o.) of ethanol on 24 trials in chronic experiments. (4) 7 or 14 days continuous administration of 20 mg/kg (p. o.) of NKK-105 in six adult male healthy volunteer exhilited marked suppression to 500 mg/kg (p. o.) alcohol effects. (7) It is thus suggested that NKK-105 inhibits the effects of alcohol, possibly by acting on liver functions, and to a lesser extent in the CNS. (8) NKK-105 did not affect mono- (MSR) and polysynaptic reflexes (PSR) in doses less than 100mg/kg (i, v.), but higher doses (150 or 200 mg/kg, i. v.) markedly influenced whole body functions, inhibiting both MSR and PSR.View full abstractDownload PDF (5788K) -
Toshihiro TAKABA, Ztunahito YOSHIZAWA, Takayasu MUSHIAKI, Makoto YAMAD ...1980 Volume 40 Issue 6 Pages 733-737
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAn experience with a J-shaped lead inserted transvenously into the right atrial appendage is described.
The patient is a 42 years old female who has experience of syncopal attack frequently. Sick sinus syndrome was diagnosed with His bundle electrocardiogramm and no abnormality of atrio-ventricular conduction system was found. So atrial permanent pace maker was implanted pervenously and good result was obtained.
Atrial pacing has significant hemodynamic and electrophysiologic advantages over ventricular pacing.View full abstractDownload PDF (3475K) -
Seishi NAGANO, Michico KUTOMI, Tsutomu HIRANO, Hikaru TAKESHITA, Takam ...1980 Volume 40 Issue 6 Pages 739-743
Published: December 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case of 67-year-old woman of diabetic lipemia was reported.
Hyperlipemia (type V) was improved remarkably after insulin therapy. Postheparin lipolytic activity (PHLA) was not low level compared with normal subject and it was increasing higher level according to insulin therapy. It's considered that physiological LPL activity in vivo is low level though PHLA is normal level in insulin deficiency, and removal defect of triglyceride exisits in each organs.View full abstractDownload PDF (472K)
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