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Volume 30, Issue 12
Displaying 1-9 of 9 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1970 Volume 30 Issue 12 Pages 759-764
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (455K) -
I. Effect of dietary protein levels on the riboflavin deficient ratsNorio Hosoda1970 Volume 30 Issue 12 Pages 765-770
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSstudies were performed on the change of physical signs with special regards to ariboflavinosis, amount of riboflavin in urine and the level and electrophoretic analysis of serum protein, in the group of rats fed by low, regular and high protein contained riboflavin deficient diet.
1. In a group of rats on riboflavin deficient diet, especially on low protein diet group, the increasing rate of the body weight were remarkably diminished as compared with those of normal control.
2. Physical signs of ariboflavinosis were seen remarkably on low protein diet group.
3. Amount of total riboflavin excretion in urine started to decrease on the second day of experiment, and reached to lowest level on the 18th day. The group fed by low protein diet showed highest rate of riboflavin excretion among these three different groups.
4. The amount of 40 γ or 200 γ of riboflavin were administered daily into the rats with ariboflavinosis and obtained improved effect on the physical signs. However, no difference was seen by the dosis given.
5. The amount of total protein and albumin in the sera showed corresponding value to the casein level in the diet.View full abstractDownload PDF (695K) -
II. Relationship of riboflavin level and serum proteinNorio Hosoda1970 Volume 30 Issue 12 Pages 771-777
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe amount of total riboflavin level and serum protein of the blood of 23 healthy, 21 obese children and 91 patients with different types of desease were determined. Also, electrophoretic analysis of serum proteinfraction were performed.
1. The average value of total riboflavin of healthy children was 8.80±0.50 γ%.
2. The average value of total riboflavin of patients was 8.63±0.46 γ%. Lower level of riboflavin value was observed in the patients with hypoalbuminemia.
3. When clinical signs of ariboflavinosis were noted, the average value of total riboflavin was low, while showing within normal value of total protein and fraction.
5. Higher level of riboflavin value was obtained in the obese children. However, no significant variation was noticed on the protein analysis.View full abstractDownload PDF (633K) -
Osamu Watanabe1970 Volume 30 Issue 12 Pages 778-787
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSerial determination of concentration of antibiotics in saliva were performed after intramuscular administration in infants and children with special reference to Kanamycin (KM) .
Results were as follows ;
1) With regard to age distribution, highest concentration of KM in saliva was seen in the latter part of neonatal period, diminishing gradually thereafter as they grow.
2) The elevation of KM concentraton in saliva after administration followed by those in blood. The highest concentration rate of KM in blood showed ten to fifteen times higher than those of in saliva. However, higher concentration of KM in saliva were observed as compared to those in blood in several subjects temporarily.
3) Concentration of KM in mixed saliva one hour after administration revealed three times higher than in parotoid saliva in rabbits.
4) In eight patients among 12 with epidemic parotitis, concentration of KM in saliva showed higher than those of healthy children.View full abstractDownload PDF (1069K) -
Nobuyuki Ishikawa1970 Volume 30 Issue 12 Pages 788-794
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSExperiments were carried to know radiation injury on resting cells. Regenerating liver adequately provided the material in this experiment. Irradiation was administered to the liver prior to partial hepatectomy. Radiation effects were estimated by DNA synthetic rate and mitosis in the regenerating liver.
From the measurement of IUdR-I uptake and from the studies of autogram, it was indicated that DNA synthetic rate was decreased and onset of the synthesis was delayed extent of which was according to the time interval between irradiation and hepatectomy ; 24 hours or more time interval revealed recovery from these injuries.
However, it was suggested in the histological research that these injuries were at least partially the results of permanent cell damage to be proliferated. These descrepancies remained to be explored.View full abstractDownload PDF (787K) -
Kiyomaro Kamakazu1970 Volume 30 Issue 12 Pages 795-807
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSGrowing pattern in size of transplanted solid tumor (Ehrlich ascites tumor) was the indicator of radiation effect combined with pyrimidine analogues in this experiment.
Intra-peritoneal injection of deoxybromouridine (BUdR) in the doses of 10 mol, 1 cc, or of 5-furuolouracil (FU) of 10 mol, 0.2 cc proved the growth inhibitory action on the tumor.
Radiation effect was enhanced by BUdR or FU. From the results of the experiment based on the difference of effectiveness owing to the time interval of administration of radiation and the drugs, or vice versa, it was likely that BUdR played the role by being incorporated into DNA before irradiation or by increased salvage into DNA after irradiation.
FU on the other hand, seemed to inhibit the recovery process, which was to take place between the time of irradiation and appearance of the radiation injury.View full abstractDownload PDF (3892K) -
Takashi Kitahara1970 Volume 30 Issue 12 Pages 808-814
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe liver is believed to be a radioresistant organ, owing, at least in part, to its regenerative capacity. Many observations were mainly based on histological experiments and were indicative of the slight vascular changes by mild doses of radiation. However, considering the fact that bone marrow cells are supplied their necessaty purine by the liver according to Lajtha's experments and the fact that there are many evidence of relation between liver injury and leukopenia, even the slight disturbance on the metabolism of the liver might well be said to influence upon the bone marrow cells.
The animal was shielded by 5 mm lead except for the part of the liver and 1000 R in air dose (150 Kvp 320 R/min) was irradiated. As the results:
1) Incorporated Glycine 2-14C into bone marrow DNA-purine of irradiated rabbit decreased at 3 hrs. on the first and the third day after irradiation comparing control animal.
2) It was likely that bone marrow cells were released immediatery after irradiation by flash labeling of 125I-UdR procedure
3) DNA synthetic rate decreased from 3 hrs. to 24 hrs, and then recovered to normal level by one hour labeling of 125I-UdR
4) Incorporation of 59FeCl3 into the bone marrow and spleen delayed after irradiation.
5) DNA spnthetic rate increased rapidly from 3 hrs. to the third day after irradiation and decreased to normal level by purine (inosine 10-5 mol. +adenine 10-5 mol.) administration to liver irradiated mice i.p.
This findings suggested that the liver irradiation influenced bone marrow DNA synthesis and the bone marrow cells recieve thier necessary purine exogenously, mainly from the liver. Administration of purine (inosine or adenine) should be believed to protect anemia and leukopenia of radiation treatment involving the liver.View full abstractDownload PDF (630K) -
Katsuyuki Ohta, Hujihiko Sugitani, Ryu Matsuzaki, Mikio Kanda1970 Volume 30 Issue 12 Pages 815-819
Published: December 28, 1970
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSA case of right ovarian serous cystadenocarcinoma of 71 year old female which has showed totally calcium deposit was repoted.
The tumor was removed surgically and weighing 530 gm., sized 10 × 7 × 7 cm.
Histopathological findings showed pupillary serous cystadenocarcinoma associated with marked calcium deposit.
The serous cystadenocinoma with marked calcium deposit is extremely rare.
A few relevant literature was reviewed.View full abstractDownload PDF (2899K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1970 Volume 30 Issue 12 Pages 820-825
Published: December 28, 1970
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (794K)
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