All issues
Volume 49 (1989)
- Issue 6 Pages 521-
- Issue 5 Pages 415-
- Issue 4 Pages 331-
- Issue 3 Pages 221-
- Issue 2 Pages 119-
- Issue 1 Pages 1-
Volume 49, Issue 2
Displaying 1-13 of 13 articles from this issue
- |<
- <
- 1
- >
- >|
-
Sohei FUJIMOTO, Takao OKAMATSU, Junichi ISHII1989 Volume 49 Issue 2 Pages 119-132
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSBirth asphyxia is believed to be related to early pathological changes in the structure of the digestive tract. The purpose of the present study was to evaluate morphological changes in the digestive tract following asphyxia, and to clarify the pathogenesis of neonatal necrotizing enterocolitis and gastric rupture. Asphyxic stress was induced by a 3-minute clamping of the airway of intubated formula-fed puppies. Each pup was necropsied 1 or 4 days after an asphyxic episode, and the digestive tract was evaluated pathologically. Gross observations revealed various degress of congestion, edema, and/or erosion in 15 out of 43 (35%) puppies with asphyxic stress. Histopathologically, the characteristic lesions of the affected intestinal walls included separation, perforation, sloughing of villous epithelials, capillary dilation, cell infiltration, edema, and hemorrhage of the mucosal and submucosal layers. The degree of damage was graded from 0 to 5. All pathological changes by gross observation were greater than grade 3, while controls were less grade 2. Noteworthy was focal hemorrhage in the gastric wall in one pup. Histologically, the hemorrhage was located in the submucosal layers, in areas where there no muscle fibers. This hemorrhaging is cogent evidence to support the suggestion that in the etiology of neonatal gastric rupture, this area becomes the weakest point of the gastric wall under increased intra-gastric pressure. These results also strongly suggest that birth asphyxia may be a major factor in neonatal necrotizing enterocolitis as well as in neonatal gastric rupture.View full abstractDownload PDF (13430K) -
Shunji HASEGAWA, Tetsumasa MIYA, Yasushi TAKAGI, Kunihide GOMI1989 Volume 49 Issue 2 Pages 133-139
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe inhibition of phosphofructokinase (PFK) by sera from patients with malignant tumors was measured to study its clinical effectiveness in tumor genesis. The inhibitory activity of the serum was measured by its reduction of PFK activity after adding it to a PFK standard. The reduction ratio was expressed as inhibition index. Sera from 100 malignant tumor patients and 59 benign disease patients were compared with sera from 100 healthy individuals. The PFK inhibition index from healthy individuals was 1.276±0.155 (mean ± SD), and the cutoff value for the normal upper limit was set at 1.586, the mean +2 SD. The PFK inhibition index of sera from malignant tumor patients, 1.503±0.232, was significantly higher (p<0.001) than that of healthy individuals, and the positive rate was 32 % (32/100) . In patients with gastric or colorectal cancer, the PFK inhibition index did not correlate with the degree of pathohistological advance. The PFK inhibition index of sera from benign diseases, 1.327±0.219, was not significantly higher (p<0.01) than that of healthy individuals, and the positive rate was 13.6 % (8/59) . The results indicate that the PFK inhibition index is applicable as an effective tumor marker. The mechanism of PFK inhibition by serum from cancer patients was not clarified, but our chemical study suggested that PFK was inhibited by heat-stable and SH modification substance in the serum.View full abstractDownload PDF (718K) -
Osamu OKAZAKI1989 Volume 49 Issue 2 Pages 140-147
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSContraction and relaxation in mammalian cardiac muscle are regulated by the change in intracellualr Ca2+ concentration ( [Ca2+] i) and modified by neurotransmitters. The aim of the present study was to clarify the effects of beta-receptor stimulation on intracellular Ca transients and tension in ferret ventricular muscle. To monitor the Ca transients, aequorin was micro-injected into superficial cells of the preparation and the resultant light signal and tension were simultaneously recorded. Isoproterenol (Iso) increased the peaks of Ca transients and tension, and shortened the decay time of Ca transients. Relaxation time was slightly shortened by Iso, but this was not statistically significant. The time required to reach peak tension and peak light was shortened. Relation between [Ca2+] i and tension obtained by tetanic contraction, produced by repetitive stimulation in the presence of ryanodine, was shifted to the right by Iso. However, maximal tension was slightly enhanced by Iso. The results were interpreted as follows : Beta-receptor stimulation potentiates tension by increasing the Ca transient peak, but the maximal tension was not dramatically changed. The main factor determining relaxation might not be the Ca uptake rate by sarcoplasmic reticulum, or Ca sensitivity change of the contractile element.View full abstractDownload PDF (925K) -
Yuukei HIGASHI, Takeshi TSUTSUMI, Hirofumi OSADA, Ken-ichi HARUMI, Fum ...1989 Volume 49 Issue 2 Pages 148-156
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis study was conducted to investigate the differences between ventricular arrhythmias (VA) of spontaneously hypertensive rat (SHR) and normotensive Wister rat (WR) after coronary artery ligation (CL) . Twenty SHR and 21 WR were used. CL was performed and electrocardiograms (ECG) were recorded for 20 min without anesthesia. Infarct was 39 % in the left ventricle of SHR and 33 % in WR. VA appeared immediately after CL, disappeared after 1 to 3 min, and reappeared after 3 min. The VA appeared significantly earlier in SHR, and the frequency within 1 min was significantly greater in SHR than in WR. Within 1 min, the average PVC was 36 in SHR, and 13 in WR (p<0.01) ; VT was 4 in SHR, and 1 in WR (p<0.01) . VF within 1 min was seen only in SHR. R wave amplitude in lead I increased to 265 % of the control in SHR, and to 228 % in W R at 15 sec, and these two increases were significantly different. ST elevation was significantly higher in SHR throughout the experiment, except at 2 mm. The incidence of ST alternans was 75 % in SHR, and 24 % in WR (p<0.05), In summary, VA after CL appeared significantly earlier in SHR than in WR, and their incidence within 1 min was significantly more frequent in SHR. The ECG changes during CL were more severe in SHR than in WR.View full abstractDownload PDF (5095K) -
Shigeki YAMAMOTO1989 Volume 49 Issue 2 Pages 157-166
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS(1) Rabbit femurs were operated on to immobilize them with plates and screws, or intramedullary nails. Bone morphometric studies were carried out on these femurs. (2) Mechanical breaking studies were performed in these femurs using TENSILON R.T.M. 1-T. (3) Dog radii were fractured experimentally. External fixation was applied to a fractured radius using a Dynamic Axial Fixator. Trabecular bone specific volume and relative osteoid volume were measured by bone morphometric technique. (4) The healing processes of human tibial and femoral fractures were clinically investigated by radiology. The cortical porosity ratio was higher in the plating group than in the intramedullary nailing group. Respectively results were : (1) The cortical porosity ratio increased with increasing thickness. (2) The maximum loading level was higher and the gradient of the curve was steeper in the thin plate group than in thick plate group. (3) The appropriate time to bear axial load was concluded to be reasonable at two weeks after fracture. (4) So-called primary fracture healing was evident in only a few cases. In intramedullary nailing group, fracture healing was mainly by bridging callus. This mode of healing was more distinct in cases in which the zone around the nail and/or screw was radiolucent. In the conservatively treated group, fracture healing was by uniting of developing callus formation.View full abstractDownload PDF (8681K) -
Hiroshi ISHIGURO1989 Volume 49 Issue 2 Pages 167-178
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSKnee taken from 66 cadavers, ranging in age from 49 to 85 years (average 68.8) were examined by macroscopic and morphological study, measurement of the thickness of articular cartilage, and analysis of subchondral bones. The results were summerized as follows : 1) Degenerative changes were clearly seen at the medial anterior surface, medial inferior condyle, and posterior condyle. 2) Degenerative changes were conspicuose in specimens whose anterior joint surfaces were almost triangular, and when the ratio between the width of the lateral posterior condyle and the width of the medial posterior condyle was greater. 3) In specimens in which the thickness of the articular cartilage was more than 3 mm, degenerative changes were clear at the center of the anterior joint surface, the medial inferior condyle, and the medial posterior condyle. 4) The difference in the thickness of mineralized trabecular with a depth of subchondral bone of 5 mm and one with 5 to 10 mm was slight, but the volume of mineralized trabecular with 5 mm depth correlated with the thickness of articular cartilage.View full abstractDownload PDF (8912K) -
Tohru KANEKO, Michinari OKAMOTO1989 Volume 49 Issue 2 Pages 179-186
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThere are many reports about how the self-recording audiogram of the normal ear is changed by narrow band noise. We have compared noise audiograms of normal ears with those obtained from ears of deaf subjects for results of self-recording audiograms measured while loading narrow band noise. The noise loaded audiogram of the ear showed a trough patteren at a frequency slightly above that of the narrow (critical) band noise loaded at the peak. It was found that many noise audiograms of ears with sensorineural deafness has some different forms. These were roughly divided into 3 types : 1) a dilated trough with the central frequency at the peak, 2) displaced peak frequency, and 3) increase in the values of zones other than those of the loaded frequency. It was found that these abnormal types were associated with the affected site of sensorineural deafness and the hearing image, and were present in many patients with complaints of abnormal hearing.View full abstractDownload PDF (1048K) -
Kyoko OHIWA, Kenji TAKEMURA1989 Volume 49 Issue 2 Pages 187-193
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSymptoms forming the core of schizophrenia were observed to view factors underlying heredity. The study was performed according to the conventional method of analyzing every pedigree obtained, in which each patient appeared as a propositus. We focused particularly on the occurrence of the same type of schizophrenia in relatives up to the third degree from the pedigree, and clinically determined the relation of the disease with personalities of parents, through whom the relative was connected to the pedigree. The core symptoms categorized as type 3 schizophrenia were strongly suspected to have dominant heredity. It seemed reasonable that monogenic locus plays a main role in the occurrence of schizophrenia, in which other supporting genes, penetrance, expressivity and environmental influences are also involved. Through this study, we felt that the most important matter to be revealed was that a way of returning to society is opened to the patient through treatment of schizophrenia, including rehabilitation and drug medication.View full abstractDownload PDF (892K) -
Akane IIDA, Masayuki IMAI, Yoshikatsu NAKATA, Yukari SUZUKI, Hiromi OG ...1989 Volume 49 Issue 2 Pages 194-198
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis is a report of the statistics of out patients, operated cases and patients introduced to our clinics in 1987. There were 30077 out patients, 9160 new patients, and 20917 repeat patients in 1987. The total number of cases increased in 1987 from 1986. Most cases were refractive error, then cataract, extraocular disease, and retinal disease in followed in that order. Neighboring related medical facilities introduced 581 cases. About half of the total cases underwent operations. Unusual cases were Harada disease, congenital anomaly of the lacrimonasal duct, etc. Among 1150 cases, cataract operations were highest with 723 cases. Of there, implantation of intraocular lens were highest with 675 cases. It is suspected that the increase in the number of cataract operations is due to the developments of modern medical technology.View full abstractDownload PDF (421K) -
Yumiko NOJIKA, Toshio MOROHOSHI, Kazuhiko SOEJIMA, Mikio KANDA, Xen Li ...1989 Volume 49 Issue 2 Pages 199-202
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCases are described in which sympathetic ophthalmia occurred due to multi-factor cumulative effects such as those caused by injection of silicone oil, multiple vitrectomy, and retinal detachment operation. Despite preservative therapy for the subsequent three and a half years, uveitis attacks recurred six times, and the damaged eye had to ultimately be extracted. Pathological examination revealed lymphocyte infiltration, and the formation of granuloma of epithelioid cells on the iris and choroidea. The retina was detached, and there was silicone oil below and within the retina. The silicone oil was partially enclosed by macrophages. Cases of sympathetic ophthalmia after vitrectomy or retinal detachment operation may increase further in the future.View full abstractDownload PDF (4090K) -
Koichi INOUE, Takayasu MUSHIAKI, Toshitaka KASHIMA, Toshiaki WATANABE, ...1989 Volume 49 Issue 2 Pages 203-205
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe anomalous aortic origin of coronary arteries has various patterns. It requires aortocoronary bypass in some cases, but there are also cases of slight anomaly of coronary arteries which are without clinical symptoms, requiring no surgical treatment. We performed preoperative coronary angiography in case of mitral valve prolapse and found an anomalous cirumflex origin of the left coronary artery. The circumflex originated from the right coronary artery, ran antero-inferiorly to the left and branched out into the obtuse marginal. Compression stenosis and organic stenosis of coronary arteries were absent. After mitral valve replacement, rupture of the chorda tendinea was noted.View full abstractDownload PDF (3025K) -
Yoshimi OSAKABE, Hajime SUZUKI, Hidehiko OHTSUKA, Yukio KATSUMURA, Eis ...1989 Volume 49 Issue 2 Pages 206-209
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCase 1 was a 66-year-old man, who visited us in Novemaer 1981 because of dyspnea and short-breath. Suspecting the presence of two lesions, bronchial asthma and pulmonary carcinoma, he received treatment that did not alleviate his asthma-like symptoms. About 2 months later, he was diagnosed by bronchoscopy to have primary pulmonary carcinoma (sequamous cell carcinoma) . Case 2 was a 71-year-old woman. She had been admitted to a hospital elsewhere two months before to receive treatment for cough, wheezing and dyspnea. Disturbance of consciousness developed adruptly, so she was admitted to our hospital and diagnosed to have primary tracheal carcinoma. We are sure that we did not overlook possible tracheal carcinoma or pulmonary carcinoma in either chest X-P of both cases. However patients without abnormal shadow in their initial chese X-P who continue to resist treatment of their asthmatic attacks, should have their chest X-P reviewed for the abnormalities overlooked and possibilities of tracheal carcinoma and pulmonary carcinoma kept in mind.View full abstractDownload PDF (1616K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1989 Volume 49 Issue 2 Pages 210-219
Published: April 28, 1989
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (1158K)
- |<
- <
- 1
- >
- >|