The present experiment has been attempted to find out whether the heart especially the myocardium of rabbit was influenced by the injection of gold containing drugs pathologi-cally.
Method of experiment:
Solganal B (Schering A.G. CO., Germany) containing organic gold was administrated as follows:
1) group A… (12.0 ml, 80 mg in all, during 45 days)
2) group B… (23.1 ml, 154 mg in all, during 198 days)
3) group C… (7.1 ml, 539.1 mg in all, during 159 days)
The morphological changes observed in the heart were as follows:
1) As the initial changes of myocardium, regressive changes, such as granular and vacuolar degeneration were chiefly found in each group, and in addition to the doses of the gold drug.
2) The interstitium was differentiated into gross interstitium and minute interstitium. The minute interstitium was divided in two types; perivascular and perimyofibral interstitium.
3) In the gross interstitium, edematous loosening was observed around vessels which revealed loosening, vacuolization, fragmentation, disappearance of elastic fiber. Fibrous proliferation as edematous sclerosis in these area has also been seen, and in cases with greater change it extended into the muscle fiber.
4) These changes were most remarkable in the left ventricular wall than other regions.
5) As the mechanism of development, they may be caused by vascular stimulative and hypoxidetic influence by the administration of gold drug, and edematous changes may play a leading part in all cardiac findings.

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Attention has been called as one of the major therapeutical problems to the recent increase of hypothyroidism which develops as a sequela after treating hyperthyroidism with radioactive iodine. However, the mechanism of its developement is as yet poorly understood.
As a means to elucidate this mechanism, biosynthetic changes in the amount of in-trathyroidal iodoamino acids and variations of ¹³¹I uptake after administration of ¹³¹I were studied in rats and discussed.
Male rats of Wistar strain were divided into 7 groups (groups A-G) . Fifty μci of ¹³¹I were given intraperitoneally to group A and 200 μci of ¹³¹I to group B, C and D. After 24 hours of ¹³¹I administration, 0.1 mg of methyl-mercaptoimidazole (MMI) was given daily to group C and 100 μg of potassium iodide (KI) was given daily to group D for 6 days. Group E and F were given only MMI and KI respectively and served as the control to groups C and D. Nothing was administered to group G which served as the normal control. Four hour-¹³¹I uptake was determined and intrathyroidal iodoamino acids were analysed paper-chromatogra-phically for periods from 4 hours up to 60 days after the administration of ¹³¹I. In the animals treated with 50 μci of ¹³¹I, 4 hr-¹³¹I uptake and thyroid hormone biosynthesis increased transiently 24 hrs after, then remained within normal range. However, disturbances in organification of iodine and in MIT synthesis continued for further experimental period.
In the animals treated with 200μci of ¹³¹I, strong disturbances in iodine uptake was observed in the early stage, whereas the biosynthesis of intrathyroidal iodomaino acids were disturbed in all stages. As compared to the other processes, disturbance in iodine accumulation and in MIT synthesis was found slight. Animals given either MMI or KI after ¹³¹I administration showed less disturbance in iodine uptake in early stage than in those adminster-ed ¹³¹I alone, although in later stage, the iodine uptake decreased in similar way to those administered ¹³¹I alone.
Biosynthesis of intrathyroidal iodoamino acids in these animals remained normal for a relatively longer period as compared with the animals given ¹³¹I alone. Prevention of radiation hazards, however, cannot be expected by as much dose of MMI or KI as this, since organization of iodine becomes intensely disturbed sooner or later.
It is apparent from these data that administration of ¹³¹I in large dose gives rise to strong dysfunction of the thyroid with no evident recovery, while in relatively small dose, iodine uptake is transiently stimulated, then disturbed, but returns to the normal level, and biosynthesis of intrathyroidal iodoamino acids remains normal for a long period. However, a possibility still exists in latter case that eventual biosynthetic disturbance of iodoamino acids leads to hypofunction of thyroid.

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3-Aminopropanesulfonic acid (homotaurine, HT) was proven to lower the blood pressure in laboratory animals, the hypotensive effect varying demonstrably among various animal species. We had also described in the previous report that chemical structures related to the hypotensive effect of several ω-aminosulfonic acids which are chemically related to HT. This time, we studied the effect on the smooth muscle, the diuretic action, and excretion in the urine of HT as well as histopathological examination of animals having received the compound, with the results as follows:
1) The motility of isolated rabbit intestine was scarcely affected by the presence of 10^-3 g HT per ml in the bath fluid but was significantly suppressed in the presence of not less than 3×10^-3 g per ml.
2) Contractile responses of isolated guinea-pig intestine produced with histamine, acetylcholine or 5-HT were inhibited by high concentrations of HT. However, the intestinal contraction with barium chloride was hardly affected by HT.
3) HT was observed to produce, when applied at high concentrations, enhancement of motility and elevation of tonus of isolated rat uterus. Inhibition of the uterine movement by adrenaline or noradrenaline was antagonized by pretreatment with HT. HT, however, failed to exert any appreciable effect upon contraction by acetylcholine.
4) Maximum doses of HT produced diuretic effects in mice and in rats.
5) From rabbits receiving single oral doses of 100 mg HT per kg, 20 to 30 per cent of the administered dose were recovered in the urine as unmodified HT compound.
6) When HT was administered orally at dosage level of 100 mg/kg daily to rabbits, a salient decrease or even complete disappearance of histidine in the basic amino acid pattern of the urine occurred from the second week after the start of oral administration onward whereas both the neutral and acid amino acid patterns of urine remained unchanged.
7) Histopathological examination of rabbits and rats which had received 100 mg of HT per kg of body weight daily for a long period of time revealed no significant adverse toxicologic findings whatsoever.

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Observations were made of the emotional response to electrostimulation at various sites of the hypothalamus via chronically implanted electrodes in unrestrained chickens and of blood pressure responses to similar electrostimulation in chicken under anesthesia, with results which may be summarized as follows:
1) In response to stimulation of the nucleus mammilaris medialis or lateralis the chicken stooped with its feathers ruffled up, making searching action and emitting clucking; noises.
2) Chickens displayed the same responses to electrostimulation of the nucleus hypothalamic inferior, nucleus hypothalamicus lateralis or posterior medialis, the birds showed warning or searching action clucking.
3) In all these cases with stimulation of the nuclei noted, elevation of the bloodd pressure was evident as a reaction to electrostimulation.
4) Neither any appreciable influence on the behavior nor change in the blood pressure was noted to occur in response to stimulation of the optic chiasma or the limbs of the optic nerves.
5) Electrostimulation at sites other than the above described produced no behavioral change or, in some instances, caused attention or warning responses alone.
6) Comparison of these findings with what is known with cats which have been studied in detail as to their emotional reactivity to electrostimulation of the brain, suggest that differences between the two species and innate disposition and degree of domestication of individual animal are intricately involved in the emotional reaction.

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The author carried out a study on 549 necropsy cases without primary disease of pancreas (tumor, inflammation, hemorrhage, necrosis, diabetes mellitus) between the years 1962 and 1969. This survey consisted primarily of pathological examination of principal athological-anato -mical changes, fibrous increase was observed in 400 cases (73%) .
Fibrous increase of the pancreas was classified morphologically into 3 types ; 1) intralo-bar type (247 cases), 2) interlobar type (59 cases), 3) mixed type (94 cases) . They were also histogenetically devided into the following three types ; 1) periductal type (297 cases) . 2) perivascular type (7 cases), 3) mixed type (96 cases) .
Fibrous increase in the pancreas originated with replacement of the residual necrosis owing to various generalized disorders, particularly of neighbouring tissues and viscerae. This fibrous tissue increases progressively and irreversively.

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An autopsy case to triple tumors that localize to the female genital organs in a 73 year-old female.
The tumors of this case were primary carcinoma of the fallopian tube, ovarial fibroma and myoma uteri. Histological finding of the epithel of the fallopian tube rewiewed typical adenocarcinoma papillo-tubulare.

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